Bluetongue virus serotype 8: Abortion and transplacental transmission in cattle in the Burgundy region, France, 2008–2009

Zanella, Gina; Durand, Benoı̂t; Sellal, Eric; Bréard, Emmanuel; Sailleau, Corinne; Zientara, Stéphan; Batten, Carrie; Mathevet, Patrice; Audeval, C.

doi:10.1016/j.theriogenology.2011.07.015

Cited by 35 publications

(37 citation statements)

References 29 publications

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“…As a consequence, these indicators had the highest number of weeks with abnormal elevations. The detection of the BTV epidemic based on the very late RTS and premature calving indicators is in agreement with the increase of abortions observed in infected herds (Zanella et al, 2012;Nusinovici et al, 2012a). On the other hand, the effect of BTV was smallest on the delayed RTS indicator, although increase in RTS is a known effect of BTV (Santman-Berends et al, 2010;Nusinovici et al, 2012b).…”

Section: The Magnitude Of Btv Effects On Reproductive Performance Indsupporting

confidence: 83%

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

Marceau

Madouasse

Lehébel

et al. 2014

Journal of Dairy Science

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In response to increasing risks of emerging infectious diseases, syndromic surveillance can be a suitable approach to detect outbreaks of such diseases across a large territory in an early phase. To implement a syndromic surveillance system, the primary challenge is to find appropriate health-related data. The objective of this study was to evaluate whether routinely collected dates of reproductive events in dairy cattle could be used to build indicators of health anomalies for syndromic surveillance. The evaluation was performed on data collected in France between 2003 and 2009. First, a set of 5 indicators was proposed to assess several types of reproductive disorders. For each indicator, the demographic coverage over the total number of cattle at risk was analyzed in time and space. Second, the ability to detect an emerging disease in an early phase was retrospectively evaluated during epidemics of bluetongue serotypes 1 and 8 (BTV-1, BTV-8) in France in 2007 and 2008. Reproductive indicators were analyzed weekly during these epidemics for each indicator in each infected French district (16 in 2007 and 50 in 2008 out of 94 districts). The indicators were able to detect the BTV epidemics despite their low demographic coverage on a weekly basis relatively to total number of cattle (median=1.21%; range=0-11.7%). Four indicators related to abortions, late embryonic death, and short gestations were abnormally elevated during both BTV epidemics. Median times to abnormal elevations in these indicators were 20 to 71 d after the first notification of clinical signs of BTV by veterinarians. These results demonstrate that reproduction data can be used as indicators of disease emergences, whereas in the specific case of these BTV epidemics, detection via these indicators was later than clinical detection by veterinarians. The emergence of bluetongue in 2007 in France was associated with gestations that were a few days shorter than expected. A short gestation indicator underwent high elevations relative to prior random fluctuations and was the earliest (out of the 4 indicators) to show abnormal elevations, making it possible to detect this emergence.

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Section: The Magnitude Of Btv Effects On Reproductive Performance Indsupporting

confidence: 83%

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

Marceau

Madouasse

Lehébel

et al. 2014

Journal of Dairy Science

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“…midges and is primarily a clinical disease of sheep and goats resulting in acute disease often leading to death4; however, there have been no reported cases of clinical bluetongue in Lao PDR. Cattle and buffalo may act as asymptomatic amplifying hosts,4 and may also have reproductive consequences including infertility, abortion, fetal mummification, stillbirths, and congenital anomalies and dysfunctions in the live offspring 5,6. Bluetongue was recently introduced into Europe where it caused significant economic losses,7 and there is also need to determine the economic consequences of BTV infections in Lao PDR resulting from reproductive losses.…”

mentioning

confidence: 99%

Seroprevalence of Q Fever, Brucellosis, and Bluetongue in Selected Provinces in Lao People's Democratic Republic

Douangngeun

Theppangna

Soukvilay

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. This study has determined the proportional seropositivity of two zoonotic diseases, Q fever and brucellosis, and bluetongue virus (BTV) which is nonzoonotic, in five provinces of Lao People's Democratic Republic (PDR) (Loungphabang, Luangnumtha, Xayaboury, Xiengkhouang, and Champasak, and Vientiane Province and Vientiane capital). A total of 1,089 samples from buffalo, cattle, pigs, and goats were tested, with seropositivity of BTV (96.7%), Q fever (1.2%), and brucellosis (0.3%). The results of this survey indicated that Q fever seropositivity is not widely distributed in Lao PDR; however, Xayaboury Province had a cluster of seropositive cattle in seven villages in four districts (Botan, Kenthao, Paklaiy, and Phiang) that share a border with Thailand. Further studies are required to determine if Xayaboury Province is indeed an epidemiological hot spot of Q fever activity. There is an urgent need to determine the levels of economic loss and human health-related issues caused by Q fever, brucellosis, and BTV in Lao PDR. Lao People's Democratic Republic (Lao PDR) is a largely agricultural society with a reliance on livestock farming to sustain livelihoods.

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“…Backx et al [14] found a possible association between the timing of seroconversion to BVDV in a single dam and the production of a BTV positive calf. However, Zanella et al [35] showed that 128 (16%) fetuses/calves analyzed in their study were BTV-8 positive but only 2 out of the 763 calves from dams that were tested were found to be coinfected with BTV-8 and BVDV while 9 fetuses/calves were exclusively BVDV positive. Thus these authors concluded that “BVDV did not play an important role as a cross-barrier enhancer”.…”

Section: Discussionmentioning

confidence: 83%

“…Previous studies have indicated that transplacental transmission of BTV-8 wt has occurred in sheep [23,24] and cattle [20,35,36] but the frequency can be quite variable varying from 0-69% in sheep [21,24,25] and 20-35% in cattle [22,26,36]. This may depend, in part, on the time of infection in relation to the gestation period.…”

Section: Discussionmentioning

confidence: 99%

Transplacental transmission of field and rescued strains of BTV-2 and BTV-8 in experimentally infected sheep

Rasmussen

Savini

Lorusso

et al. 2013

Vet Res

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Transplacental transmission of bluetongue virus has been shown previously for the North European strain of serotype 8 (BTV-8) and for tissue culture or chicken egg-adapted vaccine strains but not for field strains of other serotypes. In this study, pregnant ewes (6 per group) were inoculated with either field or rescued strains of BTV-2 and BTV-8 in order to determine the ability of these viruses to cross the placental barrier. The field BTV-2 and BTV-8 strains was passaged once in Culicoides KC cells and once in mammalian cells. All virus inoculated sheep became infected and seroconverted against the different BTV strains used in this study. BTV RNA was detectable in the blood of all but two ewes for over 28 days but infectious virus could only be detected in the blood for a much shorter period. Interestingly, transplacental transmission of BTV-2 (both field and rescued strains) was demonstrated at high efficiency (6 out of 13 lambs born to BTV-2 infected ewes) while only 1 lamb of 12 born to BTV-8 infected ewes showed evidence of in utero infection. In addition, evidence for horizontal transmission of BTV-2 between ewes was observed. As expected, the parental BTV-2 and BTV-8 viruses and the viruses rescued by reverse genetics showed very similar properties to each other. This study showed, for the first time, that transplacental transmission of BTV-2, which had been minimally passaged in cell culture, can occur; hence such transmission might be more frequent than previously thought.

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Bluetongue virus serotype 8: Abortion and transplacental transmission in cattle in the Burgundy region, France, 2008–2009

Cited by 35 publications

References 29 publications

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008

Seroprevalence of Q Fever, Brucellosis, and Bluetongue in Selected Provinces in Lao People's Democratic Republic

Transplacental transmission of field and rescued strains of BTV-2 and BTV-8 in experimentally infected sheep

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