Blushing in rosacea sufferers

Drummond, Peter D.; Su, Daphne

doi:10.1016/j.jpsychores.2011.09.002

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…The neuropeptides released from nerve endings may cause partial congestion, edema and erythema, along with the recruitment of neutrophil granulocytes and the release of mastocytes, leading to an inflammatory response. These results associated with the vascular reaction concur with the persistent face erythema and angiotelectasis exhibited in the clinic (7,20).…”

Section: Discussionsupporting

confidence: 79%

The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway

Zeng

Chen

et al. 2018

Mol Med Report

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Acne rosacea is a type of chronic dermatosis with the characteristics of erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to the side effects. Artesunate demonstrated a promising therapeutic efficacy with a high safety margin. HaCaT cells were treated with antibacterial peptide LL‑37 to simulate rosacea caused by Demodex folliculorum (D. folliculorum) infection. Cell Counting kit 8 and flow cytometry assays were performed to measure cellular proliferation, apoptosis, the stage of the cell cycle and reactive oxygen species generation in order to determine the level of cell damage. Then the damaged cells were treated with different concentrations of artesunate and doxycycline to determine the therapeutic effect of artesunate. Pro‑inflammatory cytokines tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑6, IL‑8 and C‑C motif chemokine 2 (MCP‑1) were measured using an ELISA, while western blotting was used to detect the expression of Janus kinase 2 (JAK2) and signal transducer and transcription activator (STAT3). As a result, LL‑37 treated HaCaT cells decreased in cell viability, had an increased apoptotic rate and cell cycle arrest, indicating that cell damage caused by rosacea was simulated. In addition, upregulated concentrations of the pro‑inflammatory cytokines TNF‑α, IL‑6, IL‑8 and MCP‑1 were attenuated in the artesunate group in a dose‑dependent fashion, indicating the therapeutic effect of artesunate. Furthermore, higher concentrations of artesunate exhibited an improved effect compared with the doxycycline group. In addition, increased expression levels of JAK2 and STAT3 following treatment with LL‑37 suggested that rosacea caused by D. folliculorum infection may lead to inflammation through the JAK/STAT signaling pathway. In conclusion, the potential mechanism by which damage occurs in rosacea was revealed and a promising therapeutic method against rosacea was demonstrated.

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Section: Discussionsupporting

confidence: 79%

The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway

Zeng

Chen

et al. 2018

Mol Med Report

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“…found higher blood flow in facial flushing-affected areas in patients compared with controls. 117 Interestingly, flux was greater in patients with severe rosacea than with mild rosacea 118,119 and values at PPR-affected skin were significantly higher than at unaffected skin. 115 Moreover, a decrease of flux was noticed after treatment with intense pulsed light and acupuncture, in line with clinical improvements.…”

Section: Skin Blood Flowmentioning

confidence: 95%

“…Overall, no significant differences in facial blood flow between patients and controls were seen, nor after flushing-trigger tasks. 89,115,118,119 Only Sibenge et al…”

Section: Skin Blood Flowmentioning

confidence: 99%

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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Summary Background Rosacea assessment and therapy monitoring can be challenging to standardize, as most clinical evaluation systems are prone to interobserver variability and not always validated. Therefore, objective, reliable and preferably noninvasive measurement tools are needed. Objectives To give insight into available noninvasive imaging techniques and biophysical methods in rosacea by performing a systematic review. Methods PubMed, Embase, Cochrane and Web of Science databases were searched until 1 September 2018 in accordance with PRISMA guidelines, to identify studies providing original data about objective noninvasive imaging and/or biophysical skin measurement techniques for diagnosis, assessing severity or therapy monitoring of adult patients with cutaneous facial rosacea. Risk of bias of included articles was assessed with the Cochrane Risk of Bias tool, Quality in Prognosis Studies tool, and the Newcastle–Ottawa Scale. Results A total of 78 studies were included, describing 14 imaging and biophysical methods. Widespread information about (sub)surface cutaneous morphology and functionality was obtained. Methodological study quality was relatively low and interstudy outcome variability was large. Several tools show promising value in research settings: for treatment follow‐up Demodex mites are countable with reflectance confocal microscopy, spectrometry can quantify erythema, and rosacea severity could be objectified with skin hydration‐ and transepidermal water loss measurements. Conclusions This systematic review describes the spectrum of noninvasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. What's already known about this topic? Rosacea is a chronic inflammatory skin disease with a variety of clinical manifestations. Most clinical evaluation systems are subjective, not always validated, and subsurface skin processes remain unnoticed. Currently, different types of noninvasive measurement tools are available for rosacea assessment and therapy monitoring, but a comprehensive overview is lacking. What does this study add? Seventy‐eight publications were included, describing 14 imaging and biophysical tools, providing a wide range of information about rosacea skin morphology and functionality. Reflectance confocal microscopy and spectrometry are especially promising in therapy monitoring and skin barrier measurements for rosacea severity assessment. Larger studies with better methodological quality are needed to create validated protocols for implementation into research.

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“…New treatment methods, such as laser therapy (eg, pulsed dye laser and diode laser) or topical 0.33% brimonidine gel, are still not fully satisfactory for many patients. 27 – 30 Intradermal botulinum toxin injection on refractory erythema and rosacea flushing can also be beneficial; however, further investigations are needed. 31 In some cases, psychological help, such as cognitive-behavioral therapy, may be considered as a helpful method for managing social anxiety.…”

Section: Treatment Of Psychological Symptomsmentioning

confidence: 99%

Psychosocial aspects of rosacea with a focus on anxiety and depression

Heisig

Reich²

2018

CCID

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BackgroundRosacea is a common, chronic skin condition characterized by facial redness and inflammatory lesions. The disease can lead to social stigmatization and may significantly reduce the quality of life of patients. Psychosocial impact of rosacea can be severe and debilitating; however, it is still underestimated.ObjectiveThis paper provides a literature review focused on depression and anxiety in patients with rosacea.ConclusionRosacea patients have an increased risk of developing depression and anxiety and tend to avoid social situations. However, there are still limited data on this condition. Effective treatment of clinical symptoms brings significant improvement in psychological symptoms. Further studies should be conducted to investigate in more detail the psychological impact of rosacea. In addition, improvement of the efficacy of rosacea treatment is still needed.

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Blushing in rosacea sufferers

Cited by 17 publications

References 39 publications

The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway

The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Psychosocial aspects of rosacea with a focus on anxiety and depression

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