Bmet-40nano Platform for Dynamic in Vivo Tracking of Neural Stem Cells to Brain Metastases of Breast Cancer

Abstract

INTRODUCTION: Brain metastases of breast cancer (BMBC) are the leading cause of brain malignancy and mortality in women with limited therapeutic options. Recent innovations by our group have demonstrated a novel BMBC-targeted therapeutic modality utilizing a human neural stem cell (hNSC) line approved by FDA for glioblastoma multiforme (GBM) therapy. Here we report a nano tracing strategy to expand the therapeutic scope of