2024
DOI: 10.1002/mabi.202400169
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BMP2 Binds Non‐Specifically to PEG‐Passivated Biomaterials and Induces pSMAD 1/5/9 Signalling

Jean Le Pennec,
Amaury Guibert,
Raviteja Gurram
et al.

Abstract: Biomaterials are widely employed across diverse biomedical applications and represent an attractive strategy to explore how extracellular matrix components influence cellular response. In this study, the previously developed streptavidin platforms is aimed to use to investigate the role of glycosaminoglycans (GAGs) in bone morphogenetic protein 2 (BMP2) signaling. However, it is observed that the interpretation of findings is skewed due to the GAG‐unrelated, non‐specific binding of BMP2 on components of biomat… Show more

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