BMSC-Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR-Mediated Autophagy of Nucleus Pulposus Cells

Xiao, Quan; Zhao, Zhe; Teng, Yun; Wu, Lungang; Wang, Jinlong; Xu, Hongjun; Chen, Sumei; Zhou, Quan

doi:10.1155/2022/9896444

Cited by 13 publications

(5 citation statements)

References 39 publications

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“…However, RCD has a precise molecular mechanism that can be regulated at the genetic and pharmacological levels [ 115 ]. MSC-EXO-derived ncRNAs are associated with multiple RCD modalities, such as apoptosis, ferroptosis, pyroptosis and autophagy [ 116 – 119 ].…”

Section: Msc-exo-derived Ncrnas In Mirimentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives

Chang

Cai

et al. 2023

J. of Cardiovasc. Trans. Res.

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Ischemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary intervention, and coronary artery bypass grafting to recanalize blocked vessels. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable complication of obstructive revascularization. Compared with those of myocardial ischemic injury, few effective therapeutic options are available for MIRI treatment. The pathophysiological mechanisms of MIRI involve the inflammatory response, the immune response, oxidative stress, apoptosis, intracellular Ca 2+ overload, and cardiomyocyte energy metabolism. These mechanisms exacerbate MIRI. Mesenchymal stem cell-derived exosomes (MSC-EXOs) can alleviate MIRI through these mechanisms and, to some extent, prevent the limitations caused by direct MSC administration. Therefore, using MSC-EXOs instead of MSCs to treat MIRI is a potentially beneficial cell-free treatment strategy. In this review, we describe the mechanism of action of MSC-EXO-derived noncoding RNAs in the treatment of MIRI and discuss the advantages and limitations of this strategy, as well as possible future research directions. Graphical abstract

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Section: Msc-exo-derived Ncrnas In Mirimentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives

Chang

Cai

et al. 2023

J. of Cardiovasc. Trans. Res.

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“… Zhu et al (2020) further demonstrated that MSC-derived exosomes reduced the IL-1β-induced secretion of multiple inflammatory factors as well as achieving the targeted inhibition of the MAPK signaling pathway by packaging mircoRNA-142-3P . Bone-MSC-derived exosomes were also reported to inhibit the expression of IL-1β and TNF-α and promote autophagy ( Xiao et al, 2022 ). Luo et al (2021) compared the effects of exosomes derived from normal and degenerative CEP stem cells on IDD and found that exosomes derived from normal CEP stem cells had a better effect in terms of promoting autophagy ( Figure 3 ).…”

Section: The Application Of Natural Products To Control Inflammationmentioning

confidence: 99%

Natural products can modulate inflammation in intervertebral disc degeneration

Liu

Zhu²,

Liu³

et al. 2023

Front. Pharmacol.

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Intervertebral discs (IVDs) play a crucial role in maintaining normal vertebral anatomy as well as mobile function. Intervertebral disc degeneration (IDD) is a common clinical symptom and is an important cause of low back pain (LBP). IDD is initially considered to be associated with aging and abnormal mechanical loads. However, over recent years, researchers have discovered that IDD is caused by a variety of mechanisms, including persistent inflammation, functional cell loss, accelerated extracellular matrix decomposition, the imbalance of functional components, and genetic metabolic disorders. Of these, inflammation is thought to interact with other mechanisms and is closely associated with the production of pain. Considering the key role of inflammation in IDD, the modulation of inflammation provides us with new options for mitigating the progression of degeneration and may even cause reversal. Many natural substances possess anti-inflammatory functions. Due to the wide availability of such substances, it is important that we screen and identify natural agents that are capable of regulating IVD inflammation. In fact, many studies have demonstrated the potential clinical application of natural substances for the regulation of inflammation in IDD; some of these have been proven to have excellent biosafety. In this review, we summarize the mechanisms and interactions that are responsible for inflammation in IDD and review the application of natural products for the modulation of degenerative disc inflammation.

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“…Similarly, under the stimulation of external effects, miRNA-21 can be transfected into mesenchymal cell exosomes, enhancing the ability of MSCs to differentiate into osteoblasts and promote vascular regeneration[ 10 ]. In other related studies, exosomes derived from bone marrow MSCs inhibited apoptosis and inflammation by upregulating autophagy through the protein kinase β/mammalian target of rapamycin signaling pathway[ 11 ]. MSCs-derived exosomes can also inhibit apoptosis of nucleus pulposus cells through miRNA-532-5p transport, demonstrating that this transport is also effective in IDD therapy[ 12 ].…”

Section: Mirna In Exosomesmentioning

confidence: 99%

How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration

Zhang,

Cui

2023

World J Stem Cells

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Intervertebral disc (ID) degeneration (IDD) is one of the main causes of chronic low back pain, and degenerative lesions are usually caused by an imbalance between catabolic and anabolic processes in the ID. The environment in which the ID is located is harsh, with almost no vascular distribution within the disc, and the nutrient supply relies mainly on the diffusion of oxygen and nutrients from the blood vessels located under the endplate. The stability of its internal environment also plays an important role in preventing IDD. The main feature of disc degeneration is a decrease in the number of cells. Mesenchymal stem cells have been used in the treatment of disc lesions due to their ability to differentiate into nucleus pulposus cells in a nonspecific anti-inflammatory manner. The main purpose is to promote their regeneration. The current aim of stem cell therapy is to replace the aged and metamorphosed cells in the ID and to increase the content of the extracellular matrix. The treatment of disc degeneration with stem cells has achieved good efficacy, and the current challenge is how to improve this efficacy. Here, we reviewed current treatments for disc degeneration and summarize studies on stem cell vesicles, enhancement of therapeutic effects when stem cells are mixed with related substances, and improvements in the efficacy of stem cell therapy by adjuvants under adverse conditions. We reviewed the new approaches and ideas for stem cell treatment of disc degeneration in order to contribute to the development of new therapeutic approaches to meet current challenges.

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BMSC-Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR-Mediated Autophagy of Nucleus Pulposus Cells

Cited by 13 publications

References 39 publications

Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives

Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives

Natural products can modulate inflammation in intervertebral disc degeneration

How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration

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