BmTI antigens induce a bovine protective immune response against Boophilus microplus tick

Andreotti, Renato; Gomes, Alberto; Malavazi-Piza, Kelly C; Sasaki, Sergio D.; Sampaio, Cláudio Hoffmann; Tanaka, Aparecida S.

doi:10.1016/s1567-5769(01)00203-x

Cited by 71 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ticks have developed a diverse array of antihemostatic agents that are speculated to be essential for successful blood sucking (Andreotti et al, 2002). Oliveira et al (2010) have summarized the six categories of active molecules from the salivary glands of ticks: 1) prostaglandin (Bowman et al, 1995); 2) histamine band proteins (Arocha-Pinango et al, 1999); 3) platelet aggregation inhibitor (Mans et al, 2002); 4) thrombin inhibitor (Liao et al, 2009); 5) antimicrobial protein (Lai et al, 2004b); and 6) an opioid peptide analog identified from neuroganglion, which is believed to inhibit algesthesia in the host (Lai et al, 2004a,b).…”

Section: Discussionmentioning

confidence: 99%

“…Hematophagia expands the organism to 100-fold its original size. Consecutive bites increase the risk of a complicated immune response, including that of the tick, the transmitted pathogen to the host, and a subsequent immunological rejection of the pathogen from the host (Zhao and Kong, 2000;Andreotti et al, 2002;Maritz-Olivier et al, 2007). Acquired anti-tick immunity can fight the tick to decrease blood-sucking volume, attachment time, number of engorged ticks, and the capacity of female ticks to lay eggs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration

Yu¹,

Cui²,

Zhou³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT.We investigated a possible association between bovine Toll-like receptor 4 (TLR4) and resistance to tick infestation in 103 cattle, including BMY cattle (1/2 Brahman, 1/4 Murray Grey, and 1/4 Yunnan Yellow cattle), Brahman, and Red Angus grazing on improved pasture. The tick infestation weight and number of Rhipicephalus microplus and the blood histamine concentration were measured and compared with those of 32 Chinese Holsteins and 30 Simmentals. A 228-bp fragment was amplified and sequenced to analyze the polymorphisms of the TLR4 gene. After SSCP and sequencing analysis, 4 SNPs, i.e., 535(A>C), 546(T>C), 605(T>A), and 618(G>C), were identified, corresponding to GenBank accession Nos. AY297041 and NW_003104150; the latter two SNPs caused Leu→Gln and Gln→His substitutions, respectively. Genotype AA was completely predominant in the Chinese Holstein and Simmental; genotypes AA and AB were detected in Red Angus, while genotypes AA, AB, BB, and BC were detected in Brahman and in BMY cattle. A negative correlation was identified between blood histamine concentration and number of tick infestation; in BMY cattle this negative association was significant. The tick infestation in cattle with genotype BB was significantly lower than in those with genotype AA. Blood histamine concentration in cattle with genotype BB was significantly higher than in those with genotype AA. The TLR4 gene mutation could affect the blood histamine level and activate the immune reaction after tick infestation. Allele B has potential as a molecular marker for tick-resistance originated from Zebu cattle for use in cattle breeding programs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration

Yu¹,

Cui²,

Zhou³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…A more potent BPTI-kunitz family kallikrein inhibitor, BmTI-D, which does not affect elastase, was also identified. Immunization trials with BmTIs showed 72.8% efficacy to interfere with engorgement of B. microplus ticks feeding on cattle [36]. Characterization of the response showed that BmTI-A was the most antigenic and that BmTI-D was only weakly antigenic [37].…”

Section: Box 1 How Do Ticks Obtain a Blood Meal Successfully?mentioning

confidence: 99%

Tick anti-hemostatics: targets for future vaccines and therapeutics

Maritz-Olivier

Stutzer

Jongejan

et al. 2007

Trends in Parasitology

View full text Add to dashboard Cite

“…Accordingly, Mulenga et al have recently proposed the use of tick serpins as vaccine antigens [15]. Andreotti et al [25] have observed a significant reduction of both tick number and egg weight after vaccination of cattle against a serine protease inhibitor from B. microplus. In addition, Imamura et al [16,17] have demonstrated an increased mortality of H. longicornis and R. appendiculatus during their blood meal on cattle immunized with serpins.…”

Section: Introductionmentioning

confidence: 99%

Protective immunity against Ixodes ricinus induced by a salivary serpin

Prévôt

Couvreur

Denis

et al. 2007

Vaccine

View full text Add to dashboard Cite

Iris is a specific elastase inhibitor expressed in the salivary glands of the hard tick Ixodes ricinus. It belongs to the superfamily of serpins and interferes with both haemostasis and the immune response of the host. In this study, we first show that Iris is expressed in nymphs but not in the female midgut nor in males. We also show that Iris is present in the saliva. To examine its potency as anti-tick vaccine candidate, we set up three models of I. ricinus infestation on immunized animals: nymphs on mice, and adults and nymphs on rabbits. We report the rise of neutralizing antibodies following immunization of rabbits and mice. This comes with a significant protective immunity against ticks in rabbits only, resulting in a 30% mortality rate and a diminution of weight gain in both nymphs and adults and a prolongation of blood feeding time in adults. This is the first report on an anti-tick vaccine trial on I. ricinus using a protein able to interact with both host immunity and haemostasis, as a vaccinating antigen.

show abstract

BmTI antigens induce a bovine protective immune response against Boophilus microplus tick

Cited by 71 publications

References 21 publications

Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration

Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration

Tick anti-hemostatics: targets for future vaccines and therapeutics

Protective immunity against Ixodes ricinus induced by a salivary serpin

Contact Info

Product

Resources

About