Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study

Ogundiran, Temidayo O.; Huo, Dezheng; Adenipekun, A; Campbell, O B; Oyesegun, Rasaaq; Akang, E. E. U.; Adebamowo, Clement; Olopade, Olufunmilayo I.

doi:10.1007/s10552-012-9916-y

Cited by 51 publications

(40 citation statements)

References 42 publications

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“…In the African setting, it may be more appropriate to focus on other anthropometric measures that are less prone to cachexia. Several studies have reported positive relations of either waist circumference [26] or waist-to-hip ratios (WHR) [26, 27] for both premenopausal and postmenopausal breast cancers. Hip circumference has been noted to be inversely related to risk [26].…”

Section: Role Of Previously Identified Risk Factorsmentioning

confidence: 99%

“…Several studies have reported positive relations of either waist circumference [26] or waist-to-hip ratios (WHR) [26, 27] for both premenopausal and postmenopausal breast cancers. Hip circumference has been noted to be inversely related to risk [26]. In one of these studies, the relation with WHR persisted after adjustment for obesity [25].…”

Section: Role Of Previously Identified Risk Factorsmentioning

confidence: 99%

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Breast cancer in Sub-Saharan Africa: opportunities for prevention

Brinton

Figueroa

Awuah

et al. 2014

Breast Cancer Res Treat

177

183

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Purpose Although breast cancer is a growing health problem in sub-Saharan Africa, reasons for its increased occurrence remain unclear. Methods We reviewed published literature to determine the magnitude of the increase in breast cancer, associated risk factors (including for breast cancer subtypes), and ways to reduce incidence and mortality. Results Some of the increased breast cancer occurrence likely reflects that women are living longer and adopting lifestyles that favor higher incidence rates. However, a greater proportion of breast cancers occur among premenopausal women as compared to elsewhere, which may reflect unique risk factors. Breast cancers diagnosed among African women reportedly include a disproportionate number of poor prognosis tumors, including hormone receptor negative, triple negative and core basal phenotype tumors. However, it is unclear how lack of standardized methods for tissue collection, fixation and classification contribute to these rates. Given appropriate classifications, it will be of interest to compare rates with other populations and to identify risk factors that relate to specific tumor subtypes. This includes not only risk factors that have been recognized in other populations but some that may play unique roles among African women, such as genetic factors, microbiomata, xenoestrogens, hair relaxers and skin lighteners. Conclusions With limited opportunities for effective treatment, a focus is needed on identifying etiologic factors that may be amenable to intervention. It will also be essential to understand reasons why women delay seeking care after the onset of symptoms and for there to be educational campaigns about the importance of early detection.

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Section: Role Of Previously Identified Risk Factorsmentioning

confidence: 99%

Section: Role Of Previously Identified Risk Factorsmentioning

confidence: 99%

Breast cancer in Sub-Saharan Africa: opportunities for prevention

Brinton

Figueroa

Awuah

et al. 2014

Breast Cancer Res Treat

177

183

View full text Add to dashboard Cite

show abstract

“…The majority of studies report that obesity, before menopause, is inversely related to premenopausal breast cancer (Carmichael and Bates, 2004;Palmer et al, 2007). However, a few studies report either no association or a positive association with breast cancer (Eng et al, 2005;Cecchini et al, 2012;Ogundiran et al, 2012). This complexity warrants a discussion regarding the obesity-related signaling pathways.…”

Section: Obesitymentioning

confidence: 99%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

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“…However, a few studies demonstrated a lack of this association (e.g. Cecchini et al, 2012;Ogundiran et al, 2012). Some authors suggested that BC risk is more associated with abdominal adiposity than with a BMI value (Harvie et al, 2003).…”

Section: Overweight Obesity Oxidative Stress and The Risk Of Breastmentioning

confidence: 99%

Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer

Kruk¹

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (22), 9579-9586 IntroductionBreast cancer (BC) is the most frequently diagnosed cancer in women worldwide. According to global cancer statistics, 1.38 million cancer cases (692,200 in developed and 691,300 in developing countries) accounting for 23% of all new cases of cancer worldwide, occurred in 2008 (Jemal et al., 2011). Also, 458,400 total BC deaths was estimated in this year. Incidence rate depends on the world region due to differences in race/ethnicity, reproductive and hormonal factors, physical inactivity and obesity. According to Moore's and Sobue's statement "The prevailing view is that the majority of cancers are due, very largely, to the environment, with only some 5-10% being primarily related to genetic abnormalities" (Moore and Sobue, 2009, p. 149). The prevalence of obesity is high and still increases. For example, using projection models it is suggested that in 2030 a number of obese adults will be higher by 65 million in comparison with 2010 (Wang et al., 2011). In 2008, 1.46 billion of overweighted (including 502 million obese) individuals was reported in analysis of epidemiological data from 199 countries (referred to Wang et al., 2011). As reviewed by Withrow and Alter (2011), the economic costs due to obesity are estimated to be 0.7-2.8% of the total health-care costs depending on a country. According to the World Cancer Research Found and the American Institute Cancer Research statement, there is convincing and consistent evidence that body fatness is positively correlated with the incidence of BC (WCRF/ Department of Prevention and Occupational Therapy, Faculty of Physical Culture and Health Promotion, University of Szczecin, Poland *For correspondence: e-mail AbstractThere is growing scientific evidence linking excess body weight to breast cancer risk. However, there is no common consensus on this relation due partly to methodologies used, populations studied and the cancer subtype. We report here a summary of the present state of knowledge on the role of overweight and obesity in pathogenesis of breast cancer and possible mechanisms through which excess body weight might influence the risk, focusing on the role of oxidative stress in breast cancer etiology. The findings demonstrate duality of excess body weight action in dependence on menopausal status: a statistically significant increased risk in postmenopausal overweight/ obese women and non-significant preventive effect among premenopausal women. Due to several gaps in the literature on this topic, additional studies are needed. Future research should address factors influencing the excess body weight -breast cancer relationship, such as race/ethnicity, tumor subtype, receptor status, the most appropriate measure of adiposity, reproductive characteristics, and lifestyle components.

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Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study

Cited by 51 publications

References 42 publications

Breast cancer in Sub-Saharan Africa: opportunities for prevention

Breast cancer in Sub-Saharan Africa: opportunities for prevention

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer

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