Body surface area and medication dosing in patients with heart failure with reduced ejection fraction

Brooksbank, Jeremy; Greene, Stephen J.; DeWald, Tracy A.; Mentz, Robert J.

doi:10.1016/j.tcm.2019.12.011

Cited by 3 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure S1 shows the receiver operating characteristic curve (ROC) curve of predicting poor renal prognosis with BMI and BSA (the area under the ROC curve [AUC] of BMI and BSA count were 0.530 [p = 0.109] and 0.585 [p = 0.022], respectively). Therefore, BSA has been widely used as the biometric unit for normalizing physiologic parameters and determining appropriate drug doses [37,38]. In a hemodialysis study, it was found that compared with other physical parameters, such as body weight, BSA can better reflect the nutritional level of patients and the intake of calories and dietary proteins [39].…”

Section: Discussionmentioning

confidence: 99%

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Zhang

2023

Ther Apher Dial

View full text Add to dashboard Cite

IntroductionThis study mainly discussed the relationship between body surface area (BSA) and treatment failure of peritoneal dialysis‐associated peritonitis (PDAP).MethodsThe exposures were BSA grouped by the tertiles of BSA levels. The association between BSA and the risk of treatment failure in PDAP, defined as the temporary or permanent switch to hemodialysis and kidney transplantation, was evaluated in Cox proportional hazards models.ResultsA total of 483 episodes in 285 patients were recorded in our center. As a three‐level categorical variable, in reference to G3, the G1 of BSA displayed a 4.054‐fold increased venture of treatment failure in a fully adjusted model. In sensitivity analysis, a lower value of BSA (G1) was identified as an independent risk factor for peritonitis episodes (odds ratio = 2.433, 95% confidence interval: 1.184–4.999, p = 0.015).ConclusionA lower level of body surface area was remarkably associated with a higher incidence of treatment failure among peritoneal dialysis‐associated peritonitis episodes.

show abstract

Section: Discussionmentioning

confidence: 99%

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Zhang

2023

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

“…Due to its multi-component and multi-target characteristics, traditional Chinese medicine has shown obvious potential in the treatment of AD. In addition, compared with other synthetic compounds, Chinese medicine is a natural medicine, which is widely used due to its small side effects, low effectiveness and low toxicity [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

et al. 2022

View full text Add to dashboard Cite

Background Alzheimer's Disease (AD) is a serious neurodegenerative disease and there is currently no effective treatment for AD progression. The use of TCM as a potential treatment strategy for AD is an evolving field of investigation. Asafoetida (ASF), an oleo-gum-resin isolated from Ferula assa-foetida root, has been proven to possess antioxidative potential and neuroprotective effects, which is closely associated with the neurological disorders. However, the efficacy and further mechanisms of ASF in AD experimental models are still unclear. Methods A cognitive impairment of mouse model induced by scopolamine was established to determine the neuroprotective effects of ASF in vivo, as shown by behavioral tests, biochemical assays, Nissl staining, TUNEL staining, Immunohistochemistry, western blot and qPCR. Furthermore, the PC12 cells stimulated by H2O2 were applied to explore the underlying mechanisms of ASF-mediated efficacy. Then, the UPLCM analysis and integrated network pharmacology approach was utilized to identified the main constitutes of ASF and the potential target of ASF against AD, respectively. And the main identified targets were validated in vitro by western blot, qPCR and immunofluorescence staining. Results In vivo, ASF treatment significantly ameliorated cognitive impairment induced by scopolamine, as evidenced by improving learning and memory abilities, and reducing neuronal injury, cholinergic system impairment, oxidative stress and apoptosis in the hippocampus of mice. In vitro, our results validated that ASF can dose-dependently attenuated H2O2-induced pathological oxidative stress in PC12 cells by inhibiting ROS and MDA production, as well as promoting the activities of SOD, CAT, GSH. We also found that ASF can significantly suppressed the apoptosis rate of PC12 cells increased by H2O2 exposure, which was confirmed by flow cytometry analysis. Moreover, treatment with ASF obviously attenuated H2O2-induced increase in caspase-3 and Bax expression levels, as well as decrease in Bcl-2 protein expression. KEGG enrichment analysis indicated that the PI3K/Akt/GSK3β/Nrf2 /HO-1pathway may be involved in the regulation of cognitive impairment by ASF. The results of western blot, qPCR and immunofluorescence staining of vitro assay proved it. Conclusions Collectively, our work first uncovered the significant neuroprotective effect of ASF in treating AD in vivo. Then, we processed a series of vitro experiments to clarify the biological mechanism action. These data demonstrate that ASF can inhibit oxidative stress induced neuronal apoptosis to foster the prevention of AD both in vivo and in vitro, and it may exert the function of inhibiting AD through PI3K/Akt/GSK3β/Nrf2/HO-1pathway.

show abstract

Applying guidelines directed medical therapy for heart failure: The cardiologist hard job

Fragasso

2024

Trends in Cardiovascular Medicine

View full text Add to dashboard Cite

Body surface area and medication dosing in patients with heart failure with reduced ejection fraction

Cited by 3 publications

References 39 publications

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Body surface area and treatment failure in peritoneal dialysis‐associated peritonitis

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

Applying guidelines directed medical therapy for heart failure: The cardiologist hard job

Contact Info

Product

Resources

About