Body temperature fluctuation analysis in cirrhosis

Abstract

We recently reported that patients with cirrhosis exhibit an abnormal pattern in their skin temperature variability, with complexity analysis of skin temperature fluctuations distinguishing inpatients from outpatients, despite similar mean temperature values [1]. Patients with cirrhosis also exhibit abnormalities in circadian rhythmicity, part of which are of central origin [2]. Therefore, we wondered if abnormalities in skin temperature fluctuations may reflect abnormalities in core body temperature (CBT) regulation in these patients. To test this hypothesis, we analysed CBT data that we had previously recorded in control rats and rats with cirrhosis [3]. This article is protected by copyright. All rights reserved

Which heart rate variability index is an independent predictor of mortality in cirrhosis?

“…Additionally, as recent studies have showed thermoregulatory impairment in cirrhotic patients both in skin temperature recordings and core body temperature readings (30,31).…”

Skin temperature variability is an independent predictor of survival in patients with cirrhosis

“…This has been postulated to be due to systemic vasodilation, as a result of the extensive release of endogenous vasodilators or due to the autonomic dysfunction observed in patients with cirrhosis, thus highlighting that cirrhotic patients' temperature variability profile does indeed change and is suggestive of altered thermoregulatory function, compared to healthy individuals. Mani et al also revealed that cirrhotic rats exhibit greater entropy in their core body temperature, compared to control rats, possibly indicative of an increased amount of coupling and information processing in the thermoregulatory system (Mani et al, 2018). Based on these recent studies there is evidence to suggest that cirrhosis is associated with an altered pattern in the fluctuations of patients' body temperature profile, which may indeed be correlated with multisystem involvement of cirrhosis.…”

“…A variety of different computational methods have been developed to analyze fluctuations in patients' body temperature, as well as experimental models (Ahmed et al, 2010;Mani, Mazloom, Haddadian, & Montagnese, 2018;Papaioannou et al, 2012;Satti et al, 2019). It appears that body temperature fluctuation analysis can provide crucial information regarding the integrity of one's thermoregulatory system (Mani et al, 2018;Satti et al, 2019).…”

“…A variety of different computational methods have been developed to analyze fluctuations in patients' body temperature, as well as experimental models (Ahmed et al, 2010;Mani, Mazloom, Haddadian, & Montagnese, 2018;Papaioannou et al, 2012;Satti et al, 2019). It appears that body temperature fluctuation analysis can provide crucial information regarding the integrity of one's thermoregulatory system (Mani et al, 2018;Satti et al, 2019). Recent studies have indicated that the pattern of skin temperature fluctuations has a prognostic value in critically ill patients (Cuesta et al, 2007;Papaioannou, Chouvarda, Maglaveras, Baltopoulos, & Pneumatikos, 2013;Papaioannou et al, 2012;Papaioannou, Sertaridou, Chouvarda, Kolios, & Pneumatikos, 2019;Varela et al, 2006).…”

“…It appears that systemic inflammation is involved in the pathogenesis of poor prognosis in cirrhosis (Clària et al, 2016). Systemic inflammation is linked with reduced HRV (Bhogal et al, 2019;Haddadian et al, 2013) and altered body temperature dynamics in chronic liver failure (Mani et al, 2018), so it is plausible to assess these physio-markers in prediction of poor prognosis in cirrhosis.…”