Body weight increment in patients treated with infliximab for plaque psoriasis

Florin, V.; Cottencin, A.-C.; Delaporte, E.; Staumont‐Sallé, D.

doi:10.1111/j.1468-3083.2012.04571.x

Cited by 47 publications

(49 citation statements)

References 21 publications

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“…Thus, in addition to genetic and immune-mediated mechanisms, behavioral factors may have an additional role in explaining the association between psoriasis and obesity. Although a few studies suggest that the use of tumor necrosis factor antagonists may be associated with weight gain in psoriasis patients, 39, 40, 41, 42, 43 larger studies are necessary to elucidate the effect of systemic medications on obesity. This is one potential rationale for the stronger association between obesity and severe psoriasis.…”

Section: Discussionmentioning

confidence: 99%

The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies

2012

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Objective:Psoriasis is an inflammatory skin disease affecting 2–4% of the world population. The objective of this study was to perform a systematic review and meta-analysis synthesizing the epidemiological associations between psoriasis and obesity.Data sources:We searched for observational studies from MEDLINE, EMBASE and Cochrane Central Register from 1 January 1980 to 1 January 2012. We applied the Meta-Analysis of Observational Studies in Epidemiology guidelines in the conduct of this study.Study selection:We identified 16 observational studies with a total of 2.1 million study participants (201 831 psoriasis patients) fulfilling the inclusion criteria.Results:Using random-effects meta-analysis, the pooled odds ratio (OR) for obesity among patients with psoriasis was 1.66 (95% confidence interval (CI) 1.46–1.89) compared with those without psoriasis. From the studies that reported psoriasis severity, the pooled OR for obesity among patients with mild psoriasis was 1.46 (95% CI 1.17–1.82) and the pooled OR for patients with severe psoriasis was 2.23 (95% CI 1.63–3.05). One incidence study found that psoriasis patients have a hazard ratio of 1.18 (95% CI 1.14–1.23) for new-onset obesity.Conclusions:Overall, compared with the general population, psoriasis patients have higher prevalence and incidence of obesity. Patients with severe psoriasis have greater odds of obesity than those with mild psoriasis.

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Section: Discussionmentioning

confidence: 99%

The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies

2012

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“…Reports concerning changes in body weight and BMI in psoriasis patients using anti‐tumor necrosis factor‐α (TNF‐α) agents (infliximab and etanercept) are interesting . An open, prospective, 24‐week study by Renzo et al .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of body composition parameters in patients with psoriasis

et al. 2014

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“…Thus, systemic treatment could reduce the inflammatory burden of psoriasis and its comorbidities. Interestingly, anti-TNF-α treatment with infliximab can even increase body weight [39,40,41]. The reasons for the observed increased weight among patients with anti-TNF-α therapy were not known.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

Jacobi

Langenbruch²,

Purwins³

et al. 2015

Dermatology

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Background: Psoriasis is frequently associated with obesity which possibly contributes to reduced treatment response. Objectives: Assessment of the prevalence of obesity in patients with psoriasis in Germany 2013/2014. Patients and Methods: The frequency of overweight and obesity was assessed by the body mass index (BMI) and evaluated according to the severity of psoriasis [Psoriasis Area and Severity Index (PASI)]. Results: This national, cross-sectional survey involved 83 dermatological practices and outpatient clinics, including 1,265 patients (mean age 52 years; 43.4% female). The BMI of patients with psoriasis in 2013/2014 was found to be 28.0 and therefore was significantly higher compared to that of patients with psoriasis in 2007 with a BMI of 26.9 as well as compared to the normal population in 2013 with an overall BMI of 25.9. Conclusions: The prevalence of obesity in patients with psoriasis is higher than in the normal population. The trend towards a higher BMI in patients with psoriasis continues over time.

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Body weight increment in patients treated with infliximab for plaque psoriasis

Abstract: All patients, including normal weight patients, should receive a dietary intervention.

Cited by 47 publications

References 21 publications

The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies

The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies

Evaluation of body composition parameters in patients with psoriasis

Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

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