Bone and Cartilage Tissue Engineering

Akter, F.; Ibanez, J.

doi:10.1016/b978-0-12-805361-4.00008-4

Cited by 13 publications

(17 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As these cells secrete matrix, they become trapped in spaces called lacunae and become known as osteocytes. Osteocytes communicate with the Haversian canal through cytoplasmic extensions that run through canaliculi, small interconnecting canals (Figure 4) [1,2,8,9]:…”

Section: Microscopic Bone Structurementioning

confidence: 99%

“…Lamellar bone is then constantly remodeled by osteoclasts and osteoblasts. Based on the development of bone formation can be divided into two parts, called endochondral and intramembranous bone formation/ossification [1][2][3]8].…”

Section: Bone Formationmentioning

confidence: 99%

“…Intramembranous bone formation from desmocranium (suture and periosteum) is mediated by mesenchymal skeletogenetic structures and is achieved through bone deposition and resorption [8]. This development is almost entirely controlled through local epigenetic factors and local environmental factors (i.e.…”

Section: Factors That Influence Intramembranous Bone Formationmentioning

confidence: 99%

“…Perichondral ossification begins in the perichondrium. Mesenchymal cells from the tissue differentiate into osteoblasts, which surround bony diaphyseal before endochondral ossification, indirectly affect its direction [3,8,12]. Cartilage is transformed into bone is craniofacial bone that forms at the eigth prenatal week.…”

Section: Endochondral Bone Formationmentioning

confidence: 99%

“…By the time the fetal skeleton is fully formed, cartilage only remains at the joint surface as articular cartilage and between the diaphysis and epiphysis as the epiphyseal plate, the latter of which is responsible for the longitudinal growth of bones. After birth, this same sequence of events (matrix mineralization, death of chondrocytes, invasion of blood vessels from the periosteum, and seeding with osteogenic cells that become osteoblasts) occur in the epiphyseal regions, and each of these centers of activity is referred to as a secondary ossification center [4, 8,10].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Bone Development and Growth

Setiawati¹,

Rahardjo²

2019

Osteogenesis and Bone Regeneration

View full text Add to dashboard Cite

The process of bone formation is called osteogenesis or ossification. After progenitor cells form osteoblastic lines, they proceed with three stages of development of cell differentiation, called proliferation, maturation of matrix, and mineralization. Based on its embryological origin, there are two types of ossification, called intramembranous ossification that occurs in mesenchymal cells that differentiate into osteoblast in the ossification center directly without prior cartilage formation and endochondral ossification in which bone tissue mineralization is formed through cartilage formation first. In intramembranous ossification, bone development occurs directly. In this process, mesenchymal cells proliferate into areas that have high vascularization in embryonic connective tissue in the formation of cell condensation or primary ossification centers. This cell will synthesize bone matrix in the periphery and the mesenchymal cells continue to differentiate into osteoblasts. After that, the bone will be reshaped and replaced by mature lamellar bone. Endochondral ossification will form the center of primary ossification, and the cartilage extends by proliferation of chondrocytes and deposition of cartilage matrix. After this formation, chondrocytes in the central region of the cartilage start to proceed with maturation into hypertrophic chondrocytes. After the primary ossification center is formed, the marrow cavity begins to expand toward the epiphysis. Then the subsequent stages of endochondral ossification will take place in several zones of the bone.

show abstract

Section: Microscopic Bone Structurementioning

confidence: 99%

Section: Bone Formationmentioning

confidence: 99%

Section: Factors That Influence Intramembranous Bone Formationmentioning

confidence: 99%

Section: Endochondral Bone Formationmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations