Bone and joint infection

Colston, Julia; Atkins, Bridget L.

doi:10.7861/clinmedicine.18-2-150

Cited by 52 publications

(45 citation statements)

References 17 publications

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“…The structure of the ciprofloxacin-PLGC system was analyzed using FTIR spectroscopy, as shown in Figure 2. The spectrum was recorded in the range of 4000–400 cm −1 for each sample. For ciprofloxacin, one prominent characteristic peak was found between 3500 and 3450 cm −1 , which was attributed to the stretching vibration of the OH group and intermolecular hydrogen bonding.…”

Section: Resultsmentioning

confidence: 99%

“…The spectrum was recorded in the range of 4000–400 cm −1 for each sample. For ciprofloxacin, one prominent characteristic peak was found between 3500 and 3450 cm −1 , which was attributed to the stretching vibration of the OH group and intermolecular hydrogen bonding. For PLGC, the absorption peak at 2948 cm −1 was due to C-H stretching vibrations, and the strong absorption peak at 1753 cm −1 was attributed to C=O stretching vibrations of the DLLA, GA, and CL segments.…”

Section: Resultsmentioning

confidence: 99%

“…For ciprofloxacin, one prominent characteristic peak was found between 3500 and 3450 cm −1 , which was attributed to the stretching vibration of the OH group and intermolecular hydrogen bonding. For PLGC, the absorption peak at 2948 cm −1 was due to C-H stretching vibrations, and the strong absorption peak at 1753 cm −1 was attributed to C=O stretching vibrations of the DLLA, GA, and CL segments. The peaks at 1183 cm −1 and 1090 cm −1 were attributed to C-O-C stretching vibrations, and the peaks at 1453 cm −1 and 1385 cm −1 were assigned to C-H bending vibrations of DLLA, GA, and CL segments.…”

Section: Resultsmentioning

confidence: 99%

“…Osteomyelitis is bone inflammation caused by infectious microorganisms. 1 Additionally, osteomyelitis can also spread from infected tissues, such as following surgery, open fractures, and joint replacement. 2 After entering into the body, most bacteria adhere to the surface of necrotic soft tissue and bone tissue in a static state and form a bacterial biofilm, which has a protective effect on bacteria and greatly enhances bacterial resistance to antibiotics, making it difficult for bacteria to be completely removed.…”

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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Chronic osteomyelitis causes serious injury to patients. Antibiotic delivery systems based on poly(lactide-co-glycolide) (PLGA) have great potential for treatment of chronic osteomyelitis. However, PLGA has a glass-transition temperature that is higher than physiological temperatures, resulting in a lack of flexibility for implantation into the bone marrow cavity. As an alternative, poly(d, l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) presents good flexibility due to the introduction of poly(ε-caprolactone) segments. To develop a new strategy for treatment of chronic osteomyelitis, a ciprofloxacin delivery system was prepared using PLGC as carriers, the antibacterial effects of which were evaluated both in vivo and in vitro. The in vitro release behavior showed that the average release reached 268.5 μg/days on day 33, with a cumulative release rate of 56.01%. A bacteriostatic ring, with a diameter of 26.83 ± 0.83 mm, was produced by ciprofloxacin against Staphylococcus aureus after 30 days of release via our ciprofloxacin-PLGC system. After 4 weeks of treatment in vivo, chronic-osteomyelitis-model rats had a bodyweight of 385.83 ± 17.23 g and a normal white-blood-cell count, as well as a lower number of bacterial colonies per gram of bone tissue of (10.6 ± 3.0) × 101 CFU/g. Furthermore, no inflammatory cells were observed via hematoxylin-and-eosin staining, and normal bone structure was observed via X-ray. Taken together, our findings indicate that our novel ciprofloxacin-PLGC system yielded noteworthy antibacterial effects both in vitro and in vivo, suggesting that it may be useful for treating patients with chronic osteomyelitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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“…The wide spectrum of bone and joint pathologies include infection of prostheses, osteomyelitis, and septic arthritis. 19…”

Section: Infection Of Bones and Joints By S Aureusmentioning

confidence: 99%

Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India

Prabhoo¹,

Chaddha²,

Iyer³

et al. 2019

Orthop Rev (Pavia)

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Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti-MRSA agents have their own limitations with regards to reduced susceptibility as well as safety and tolerability. Furthermore, biofilms over the prosthesis with invariably multi-drug resistant strains leads to complex treatment processes. This necessitates the need to develop and screen new antibiotics against MRSA that can easily penetrate the deep pockets of infection and take care of the challenges discussed. This review aims to discuss on MRSA infection in bone and joint infection, current antibiotic regimen, its associated limitations, and finally, the need to develop new antibiotic therapy for effective management of patients with BJI.

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Investigating the structure, solubility, and antibacterial properties of silver‐ and copper‐doped hydroxyapatite

et al. 2022

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Hydroxyapatite (HA) powders were synthesized by the wet precipitation method in which two experimental compositions were synthesized (10 mol% Ag-HA and Cu-HA)where the CaNO 3 content was partially substituted with AgNO 3 and Cu(NO 3 ) 2 .X-ray diffraction (XRD) was employed to characterize changes to the HA structure as the dopants (Cu 2+ , Ag + ) were incorporated into the materials structure. Energydispersive X-ray spectroscopy (EDS) determined confirmed the compositions and found that the Ca/P ratio was 1.63 for the control (HA) while Ag-HA and Cu-HA exhibited (X + Ca)/P ratios of 1.79 and 1.65, respectively. Antibacterial efficacies were evaluated against E. coli and S. aureus, as a function of surface area and incubation time. The more prominent antibacterial effects were observed with both Ag-HA and Cu-HA and the materials antibacterial influence was maintained with respect to time. Ion release studies of each HA composition (15, 30, and 45 days) showed that Cu-HA released significantly more Cu 2+ (36.1 ± 5.1 mg/L) than Ag + (2.9 ± 1.2 mg/L) from Ag-HA. Analysis of each composition incubated in simulated body fluid (SBF) exhibited surface depositions that are likely calcium phosphate (CaP). Cytocompatibility testing in MC 3T3 Osteoblasts showed slight reductions in cell viability when tested using MTT assay, however cell adhesion studies were positive for each composition.

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Bone and joint infection

Cited by 52 publications

References 17 publications

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India

Investigating the structure, solubility, and antibacterial properties of silver‐ and copper‐doped hydroxyapatite

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