Bone and Muscle Crosstalk in Aging

He, Chen; He, Wenzhen; Hou, Jing; Chen, Kaixuan; Huang, Mei; Yang, Mingzhi; Luo, Xiang‐Hang; Li, Changjun

doi:10.3389/fcell.2020.585644

Cited by 83 publications

(85 citation statements)

References 179 publications

(308 reference statements)

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“…Additionally, grip strength was also a significant contributor to the model, further supporting the idea that the association between BMD and SB is mediated by muscle strength. This finding reinforces the idea of the crosstalk between muscle and bone, suggesting a shared pathological process in older adults [ 14 , 61 ]. Previous studies reported the negative impact of SB, independently of PA, on bone integrity [ 62 ].…”

Section: Discussionsupporting

confidence: 89%

Intensity Matters for Musculoskeletal Health: A Cross-Sectional Study on Movement Behaviors of Older Adults from High-Income Scottish and Low-Income South African Communities

Pina

Mendham

Tomaz

et al. 2021

IJERPH

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This study aimed to investigate differences in physical activity (PA) patterns and the associations between objectively measured 24-h movement behaviors and musculoskeletal measures (muscle strength, muscle mass, physical performance, and bone mineral density) in a high-income and a low-income community. This cross-sectional study recruited independent living older adults aged 60–85 years from high-income Scottish (n = 150) and low-income South African (n = 138) settings. Participants completed demographic and health questionnaires, and testing included body composition and bone mineral density (dual energy X-ray absorptiometry), physical performance (grip strength, gait speed), and PA (accelerometry). Participants accumulated similar amounts of weekly total PA, however, the Scottish cohort engaged in more moderate-to-vigorous intensity PA (MVPA) and sedentary behavior (SB), while the South African cohort spent more time sleeping and in light intensity PA (LPA). From compositional data analysis, more time spent in MVPA relative to the other movement behaviors was positively associated with higher muscle mass (p < 0.001) and strength (p = 0.001) in the Scottish cohort. Conversely, more time spent in MVPA was associated with faster gait speed (p < 0.001) and greater hip bone mineral density (p = 0.011) in the South African cohort. Our findings confirm the beneficial role of MVPA in both high- and low-income cohorts, however, the relationship MVPA had with components of musculoskeletal health in older adults differed between settings.

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Section: Discussionsupporting

confidence: 89%

Intensity Matters for Musculoskeletal Health: A Cross-Sectional Study on Movement Behaviors of Older Adults from High-Income Scottish and Low-Income South African Communities

Pina

Mendham

Tomaz

et al. 2021

IJERPH

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“…Furthermore, several scientific studies agree that both tissues perform an important endocrine function, whose products, represented by osteokines for bone tissue and myokines for muscle tissue, have been proposed as possible key players in bone–muscle crosstalk [ 2 , 6 , 33 ]. Levels of these signal molecules can also vary with age and physical activity [ 34 ]. Therefore, the identification of these molecules and understanding their role within the bone–muscle system is currently a major challenge to identify potential pharmacological targets and to prevent and/or treat bone–muscle diseases related to aging and sedentariness.…”

Section: Bone–muscle Crosstalk: Mechanical and Biochemical Aspectsmentioning

confidence: 99%

Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications

Cariati

Bonanni

Onorato

et al. 2021

JFMK

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Bone and muscle tissues influence each other through the integration of mechanical and biochemical signals, giving rise to bone–muscle crosstalk. They are also known to secrete osteokines, myokines, and cytokines into the circulation, influencing the biological and pathological activities in local and distant organs and cells. In this regard, even osteoporosis and sarcopenia, which were initially thought to be two independent diseases, have recently been defined under the term “osteosarcopenia”, to indicate a synergistic condition of low bone mass with muscle atrophy and hypofunction. Undoubtedly, osteosarcopenia is a major public health concern, being associated with high rates of morbidity and mortality. The best current defence against osteosarcopenia is prevention based on a healthy lifestyle and regular exercise. The most appropriate type, intensity, duration, and frequency of exercise to positively influence osteosarcopenia are not yet known. However, combined programmes of progressive resistance exercises, weight-bearing impact exercises, and challenging balance/mobility activities currently appear to be the most effective in optimising musculoskeletal health and function. Based on this evidence, the aim of our review was to summarize the current knowledge about the role of exercise in bone–muscle crosstalk, highlighting how it may represent an effective alternative strategy to prevent and/or counteract the onset of osteosarcopenia.

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“…miRNAs are a class of small non-coding RNAs that play key roles in controlling skeletal muscle development [ 6 ]. In the past decade, the ability of miRNAs to bind the 3’-UTR of target mRNAs to perform biological functions has been widely accepted [ 7 , 8 ]. For example, miR-206 played a key role in enhancing slow skeletal muscle and muscular dimorphism [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits

et al. 2021

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Background miRNA is one of the crucial roles in the complex and dynamic network that regulates the development of skeletal muscle. The landscape of skeletal muscle miRNAs from fetus to adult in New Zealand rabbits has not been revealed yet. Results In this study, nine RNA-seq libraries of fetus, child and adult rabbits’ leg muscles were constructed. A total of 278 differentially expressed miRNAs (DEmiRNAs) were identified. In the fetus vs. child group, the main functional enrichments were involved in membrane and transport. Pathway enriched terms of up-regulated DEmiRNAs were connected with the differentiation and hypertrophy of skeletal muscle, and down-regulated ones were related to muscle structure and metabolic capacity. In the child vs. adult group, functions were associated to positioning and transportation, and pathways were relevant to ECM, muscle structure and hypertrophy. Finally, ocu-miR-185-3p and ocu-miR-370-3p, which had the most target genes, were identified as hub-miRNAs in these two groups. Conclusions In short, we summarized the highly expressed and uniquely expressed DEmiRNAs of fetus, child and adult rabbits’ leg muscles. Besides, the potential functional changes of miRNAs in two consecutive stages have been explored. Among them, the ocu-miR-185-3p and ocu-miR-370-3p with the most target genes were selected as hub-miRNAs. These data improved the understanding of the regulatory molecules of meat rabbit development, and provided a novel perspective for molecular breeding of meat rabbits.

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Bone and Muscle Crosstalk in Aging

Cited by 83 publications

References 179 publications

Intensity Matters for Musculoskeletal Health: A Cross-Sectional Study on Movement Behaviors of Older Adults from High-Income Scottish and Low-Income South African Communities

Intensity Matters for Musculoskeletal Health: A Cross-Sectional Study on Movement Behaviors of Older Adults from High-Income Scottish and Low-Income South African Communities

Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications

Dynamic changes of miRNAs in skeletal muscle development at New Zealand rabbits

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