Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

Findlay, David M.; Kuliwaba, J.S.

doi:10.1038/boneres.2016.28

Cited by 213 publications

(183 citation statements)

References 106 publications

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“…Bone cartilage crosstalk is consider as one of the key factors in understanding OA pathogenesis . A hypothetical model for OA pathogenesis has been proposed by Burr et.…”

Section: Analysis Of Bone Remodelingmentioning

confidence: 99%

Translation of morphological and functional musculoskeletal imaging

Pedoia

Majumdar

2018

Journal Orthopaedic Research

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In an effort to develop quantitative biomarkers for degenerative joint disease and fill the void that exists for diagnosing, monitoring, and assessing the extent of whole joint degeneration, the past decade has been marked by a greatly increased role of noninvasive imaging. This coupled with recent advances in image processing and deep learning opens new possibilities for promising quantitative techniques. The clinical translation of quantitative imaging was previously hampered by tedious non‐scalable and subjective image analysis. Osteoarthritis (OA) diagnosis using X‐rays can be automated by the use of deep learning models and pilot studies showed feasibility of using similar techniques to reliably segment multiple musculoskeletal tissues and detect and stage the severity of morphological abnormalities in magnetic resonance imaging (MRI). Automation and more advanced feature extraction techniques have applications on larger more heterogeneous samples. Analyses based on voxel based relaxometry have shown local patterns in relaxation time elevations and local correlations with outcome variables. Bone cartilage interactions are also enhanced by the analysis of three‐dimensional bone morphology and the potential for the assessment of metabolic activity with simultaneous Positron Emission Tomography (PET)/MR systems. Novel techniques in image processing and deep learning are augmenting imaging to be a source of quantitative and reliable data and new multidimensional analytics allow us to exploit the interactions of data from various sources. In this review, we aim to summarize recent advances in quantitative imaging, the application of image processing and deep learning techniques to study knee and hip OA. ©2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res XX:XX–XX, 2018.

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“…Bone cartilage crosstalk is consider as one of the key factors in understanding OA pathogenesis . A hypothetical model for OA pathogenesis has been proposed by Burr et.…”

Section: Analysis Of Bone Remodelingmentioning

confidence: 99%

Translation of morphological and functional musculoskeletal imaging

Pedoia

Majumdar

2018

Journal Orthopaedic Research

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“…In many conventional tissue engineering approaches, the “interface” is an unintentional by‐product of combining the two main parts of the osteochondral construct, which were connected by just press‐fitting, suturing, melting, or gluing prior to implantation . However, further insights in the anatomy and function of the osteochondral interface have underscored the importance of proper integration between the bone and cartilage compartments . Incorporation of a calcified cartilage zone could improve interfacial shear strength of osteochondral constructs .…”

Section: Mimicking the Layered Structure Of Native Tissuementioning

confidence: 99%

From intricate to integrated: Biofabrication of articulating joints

Groen

Diloksumpan²,

Weeren³

et al. 2017

Journal Orthopaedic Research

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Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self‐healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology. Herein, we address the current challenges to recapitulate the complexity of articulating joints and how biofabrication could overcome them. The combination of multiple materials, biological cues and cells in a layer‐by‐layer fashion, can assist in reproducing both the zonal organization of cartilage and the gradual transition from resilient cartilage toward the subchondral bone in biofabricated osteochondral grafts. In this way, optimal integration of engineered constructs with the natural surrounding tissues can be obtained. Mechanical characteristics, including the smoothness and low friction that are hallmarks of the articular surface, can be tuned with multi‐head or hybrid printers by controlling the spatial patterning of printed structures. Moreover, biofabrication can use digital medical images as blueprints for printing patient‐specific implants. Finally, the current rapid advances in biofabrication hold significant potential for developing joint‐on‐a‐chip models for personalized medicine and drug testing or even for the creation of implants that may be used to treat larger parts of the articulating joint. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 35:2089–2097, 2017.

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“…Em particular, consideram-se as interações entre osso subcondral e cartilagens, causadores de degenerações e calci icações ósse-as e das alterações em lesão de cartilagens como causa central da OA. Há evidencias de manifestações bioquıḿ icas e biomecânicas à progressão da doença/sıń drome 12 AO. Vários fatores de riscos são propostos incluindo obesidade, fraqueza muscular, caracterıś ticas ocupacionais, alimentação, esporte de alto rendimento entre outros.…”

Section: Dor Articular In Lamatóriaunclassified

“…Vários fatores de riscos são propostos incluindo obesidade, fraqueza muscular, caracterıś ticas ocupacionais, alimentação, esporte de alto rendimento entre outros. Contudo, de forma geral, ainda há baixo nıv el de 12,13 evidencia cientı ́ica na causuıś tica.…”

Section: Dor Articular In Lamatóriaunclassified

Dor articular: inflamatória ou neuropática? / Joint pain: inflammatory or neuropathic pain?

Souza¹

2017

Rev Cienc Saude

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Neste artigo de revisão narrativa atualizam-se alguns conceitos de dor articular. A prevalencia da dor articular aumenta com o avanço da idade, assim como os custos no tratamento das limitações e incapacidades. Compreender as diferenças entre dor aguda e dor crônica permite melhor abordagem das dores articulares, onde a primeira representa um sinal de alerta e a segunda é considerada uma patologia em si. As causas da croni icação da dor ainda são incertas, poreḿ, alguns modelos são propostos e discutidos, como a sensibilização central por excesso de informação nociceptiva, seja esta de origem in lamatória, traumática ou outra. Em dores crônicas in lamatórias -como nas Artrites reumatoidesdestaca-se a importância de iniciar o tratamento precoce de forma agressiva para inibir o processo in lamatório e as deformidades estruturais. Osteoartrites, embora sejam predominantemente descritas por suas alterações degenerativas nas articulações, tem atualmente reconhecida sua fase in lamatória inicial. A dor articular tende a ser abordada predominantemente sob o ponto de vista biomecânico e in lamatório, contudo, a ausencia da abordagem do componente neuropática da dor crônica, nas fases iniciais, é uma das causas de elevados custos e de grandes deformidades articulares. Finalmente abordase a importância do movimento e da educação do paciente com dor articular com base no modelo biopsicossocial de saúde e dor. Keywords:Joint pain Rheumatoid arthritis Osteoarthritis In lammatory and neuropathic pain ABSTRACT This article is a joint pain update. Prevalence rates, incapacity, and social and economic burden of joint pain increase with the advancing age. Understanding differences about acute and chronic pain could improve therapeutic approaches. Negligence early treatment of acute joint pain can increase costs of treatment and joint deformities. Rheumatoid arthritis guidelines propose an aggressive initial approach of treatment with the aim to protect joint structure from in lammation and deformity. In addition to in lammatory joint pain, the neuropathic pain was also explained; central sensitization and neuropathic pain associated to joint pain. Finally, the importance of motion and education of patients with chronic pain were addressed following the pain and health biopsychosocial model. IntroduçãoAs dores articulares estão entre as mais prevalentes na população adulta e idosa. Entre elas, a articulação do joelho e a coluna vertebral são as mais investigadas. Estima-se que ao questionar adultos sobre a presença de dor no joelho, 30% responde de forma a irmativa, e esta porcentagem aumenta para entre 60% e 85% quando questionados sobre a presença de dores nas costas, nos últimos 1 trinta dias. As articulações consistem no eixo do movimento -quando saudaveis -garantem a funcionalidade e autonomia do ser humano, por meio de movimentos como a locomoção e a própria respiração. Desta forma, as limitações geradas pela dor articular classi icam-na como a segunda maior causa de incapacidade fıś ica ...

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Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

Cited by 213 publications

References 106 publications

Translation of morphological and functional musculoskeletal imaging

Translation of morphological and functional musculoskeletal imaging

From intricate to integrated: Biofabrication of articulating joints

Dor articular: inflamatória ou neuropática? / Joint pain: inflammatory or neuropathic pain?

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