Bone cement based nanohybrid as a super biomaterial for bone healing

Kapusetti, Govinda; Misra, Nira; Singh, Vakil; Srivastava, Swati; Roy, Partha; Dana, Kausik; Maiti, Pralay

doi:10.1039/c4tb00501e

Cited by 37 publications

(24 citation statements)

References 51 publications

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“…its nanohybrid with NK75 nanoclay (BC-NK75) material is compared in vivo in rabbit tibias show complete healing in just 30 days using nanohybrid against healing of 90 days for pure bone cement [183]. However, polyesters especially PLA, PCL and PBS are the good sources for making bio-scaffold due to their processability, mechanical properties, biocompatibility, consistent degradation and mineralization in an appropriate time frame.…”

Section: Addition Of Modifiedmentioning

confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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The disposal of non-degradable plastics is augmented exponentially as a result of poor recycling efficacy. The development of biodegradable plastics has become indispensable in last two decades because of its origin from renewable resources. The potential interest in biodegradable plastics involves eco-friendly obliteration via microbial action which transform into carbon dioxide and water resulting pollution free natural system. Even though its lucrative interest lies in multiple areas, some of the properties such as brittleness, poor thermal, mechanical and low gas barrier properties restrict their practical uses. Incorporation of nanoparticle in polymer matrix or by making nanocomposites overcomes the shortcomings of the biodegradable polymers. For further improving the aforementioned properties, several approaches have been utilized especially incorporation of nanoparticle in polymer matrix to prepare nanocomposites. One of the great advantages of nanoparticles is to tune the rate of biodegradation (both increase and decrease as compared to the rate of pure polymer) depending upon the need. Thus, chemical, physical and biological properties of the biodegradable polymers can be modified and controlled for sustainable application in medical and other areas. This review considers the major concerns about the type of biodegradable polyesters and their nanocomposites, great details about mechanism of biodegradation, factors influencing the biodegradation and their applications in biomedical and packaging industries.

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Section: Addition Of Modifiedmentioning

confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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“…The media was discarded and added DMSO to dissolve the formazan crystals. The absorption was recorded at 570 nm by using UV‐plate reader (Kapusetti et al, ; Sharma et al, ; Multiskan™ GO, Thermo Scientific, Finland) and data acquisition was done by using SkanIt software (generation 4). The study was carried out in triplicate.…”

Section: Methodsmentioning

confidence: 99%

“…The attached cells were stained by using 0.5% crystal violet aqueous solution for 30 min. The 10% acetic acid was added and the absorbance was taken at 570 nm using UV-plate reader (Kapusetti et al, 2014;Sharma et al, 2017; Multiskan™ GO, Thermo Scientific, Finland).…”

Section: Cell Adhesion Studymentioning

confidence: 99%

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Choppadandi

Kapusetti

2019

J Biomedical Materials Res

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Poly(methyl methacrylate) (PMMA) bone cement is the most widely used grouting material in the joint arthroplasties and vertebroplasties. The present investigation has been carried out to scavenge the radicals and monomer by addition of an antioxidant to minimize the toxicity of bone cement (BC). The in silico studies were employed to determine the potent natural antioxidant at physiological conditions. The antioxidant methionine demonstrated a strong binding affinity with free radicals and methyl methacrylate (MMA) monomer than cysteine. The designated amount of methionine was optimized by various assay methods and >2% methionine shows strong scavenging capacity in BC. Moreover, the antioxidant‐loaded BC (ABC) demonstrated similar handling, physicochemical and mechanical properties to pristine bone cement. Significantly, the developed formulation shows superior biological characteristics such as cell proliferation (2 ± 1 BC and 6 ± 1 ABC), adhesion (0.32 ± 0.02 BC and 0.54 ± 0.01 ABC), and cell viability (81 ± 2% BC and 93 ± 1% ABC) toward human osteoblast‐like cells (MG‐63). Therefore, the novel antioxidant bone cement is a potential candidate for various orthopedic applications to eliminate the adverse effects, related to residual toxic radical and monomer in bone cement.

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“…The composite samples were sterilized in an autoclave at 121°C for 30min. MG63 cells were cultured in a minimum essential medium (MEM; Invitrogen Corporation), augmented with 10% of fetal calf serum (FCS), 1% antibiotic antimycotic solution in a humidified atmosphere at 37°C and with 5% CO 2 for 24, 48 and 72 h. The methyl thiazolyl tetrazolium (MTT) [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay was used to evaluate cell viability and cytotoxicity [28,29].…”

Section: In-vitro Cell Culturementioning

confidence: 99%