Bone formation at a ceramic implant interface

Beckham, C; Greenlee, Theodore K.; Crebo, A. R.

doi:10.1007/bf02010133

Cited by 78 publications

(34 citation statements)

References 8 publications

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“…amorphous, partially crystalline and fully crystalline) was studied both in vitro and in vivo. All implants examined bonded to a rat femur model within 6 weeks, with no differences in this respect between the vitreous and crystalline implants (4,8,9). This allowed to establish a series of isobioactivity lines as a function of the glass composition that are shown in the 6 wt% P 2 O 5 section of the SiO 2 -CaO-Na 2 O-P 2 O 5 system (Fig.…”

Section: Bioactive Glassesmentioning

confidence: 99%

Vidrios y Vitrocerámicos Bioactivos

Aza¹,

Aza²,

Peña³

et al. 2007

Bol. Soc. Esp. Ceram. Vidr.

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Since the late 1960´s, a great interest in the use of bioceramic materials for biomedical applications has been developed. In a previous paper, the authors reviewed crystalline bioceramic materials "sensus stricto", it is to say, those ceramic materials, constituted for non-metallic inorganic compounds, crystallines and consolidates by thermal treatment of powders at high temperature. In the present review, the authors deal with those called bioactive glasses and glassceramics. Although all of them are also obtained by thermal treatment at high temperature, the first are amorphous and the second are obtained by devitrification of a glass, although the vitreous phase normally prevails on the crystalline phases.After an introduction to the concept of bioactive materials, a short historical review of the bioactive glasses development is made. Its preparation, reactivity in physiological media, mechanism of bonding to living tissues and mechanical strength of the bone-implant interface is also reported. Next, the concept of glass-ceramic and the way of its preparation are exposed. The composition, physicochemical properties and biological behaviour of the principal types of bioactive glasses and glass-ceramic materials: Bioglass Vidrios y Vitrocerámicos BioactivosDesde finales de los años sesenta, se ha despertado un gran interés por el uso de los materiales biocerámicos para aplicaciones biomédicas. En un trabajo previo, los autores hicieron una revisión de los denominados materiales biocerámicos cristalinos en sentido estricto, es decir, de aquellos materiales, constituidos por compuestos inorgánicos no metálicos, cristalinos y consolidados mediante tratamientos térmicos a altas temperaturas. En el presente trabajo, los autores revisan el desarrollo de los vidrios bioactivos (biovidrios) y de las vitrocerámicas bioactivas. Si bien todos ellos son obtenidos también por tratamiento térmico a altas temperaturas, los primeros son amorfos y los segundos son obtenidos por desvitrificación de un vidrio, si bien la fase vítrea normalmente predomina sobre las fases cristalinas. Después de una introducción al concepto de material bioactivo, se expone una breve revisión histórica del desarrollo de los vidrios bioactivos. A continuación se describe su obtención, reactividad en suero fisiológico artificial, mecanismo de unión al tejido vivo y resistencia mecánica de la interfaz hueso-implante. Posteriormente, se expone el concepto de material vitrocerámico y el proceso de su obtención así como también se describen los principales tipos de vidrios y vitrocerámicos bioactivos (Bioglass ® , Ceravital ® , Cerabone ® , Ilmaplant ® and Bioverit ® ), sus composiciones, sus propiedades físico-químicas y sus comportamientos biológicos. Finalmente, se lleva a cabo también una corta revisión de los recubrimientos con vidrios bioactivos y de los materiales compuestos (composites) bioactivos así como de los usos más comunes de los vidrios y vitrocerámicos bioactivos.

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Section: Bioactive Glassesmentioning

confidence: 99%

Vidrios y Vitrocerámicos Bioactivos

Aza¹,

Aza²,

Peña³

et al. 2007

Bol. Soc. Esp. Ceram. Vidr.

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“…The interfacial bond between a bioactive glass and bone is composed of hydroxycarbonate apatite (HCA) crystals bonded to collagen fibers [1][2][3].…”

Section: Era Of Discovery Questionsmentioning

confidence: 99%

“…Answers should appear in the journal in the years ahead. This finding was the basis for the first paper published in 1971 in the Journal of Biomedical Materials Research that summarised the in vivo results and the in vitro tests that provided an explanation for the interfacial bonding of the implant to bone [1][2][3]. The in vitro tests showed that the 45S5 Bioglass composition (see Table 1) developed a hydroxyapatite (HA) layer in test solutions.…”

Section: Introductionmentioning

confidence: 96%

“…This concept of regeneration of tissues instead of replacing them is possible in part to the development of second and third generation bioactive materials, especially bioactive glasses. In 1969 began the development of second generation bioactive materials capable of bonding to hard and soft connective tissues [1][2][3][4][5][6][7][8][9][10][11][12][13] and third generation bioactive resorbable materials, specifically designed for tissue regeneration [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…The HA crystals in vivo were bonded to layers of collagen fibrils produced at the interface by osteoblasts. The chemical bonding of the HA layer to collagen created the strongly bonded interface [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development

Hench¹

2015

Biomedical Glasses

106

101

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Historically the function of biomaterials was to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasseswere discovered in 1969 and provided for the first time an alternative; strong, stable interfacial bonding of an implant with host tissues. In the 1980’s it was discovered that bioactive glasses could be used in particulae form to stimulate osteogenesiswhich thereby led to the concept of regeneration of tissues. This article summarizes the four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglassr. The four eras are; A) Era of Discovery, B) Era of Clinical Application, C) Era of Tissue Regeneration, and D) Era of Innovation. Key scientific and technological questions answered for the first three eras are presented. Questions still to be answered for the fourth era are included to stimulate innovation in the field.

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Porous bioactive glass and hydroxyapatite ceramic affect bone cell functionin vitro along different time lines

El‐Ghannam

Ducheyne

Shapiro

1997

J. Biomed. Mater. Res.

118

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We describe the effects on cell function of treating porous bioactive glass (BG) such that its surface is a composite of carbonated hydroxyapatite and serum protein. The effects on bone cell function of porous hydroxyapatite (HA) ceramic and porous glass treated to become amorphous calcium phosphate only also were studied subsequent to their having adsorbed a serum protein layer. Substrates treated for different durations were seeded with MC3T3-E1 cells and cultured for 3-17 days. Whereas cells seeded on any substrates, BG and HA produced collagen types I and III, bone sialoprotein, and osteopontin, there were significant differences between HA and BG, and among the various surface conditions created on BG. Covering the glass surface with hydroxyapatite and serum protein enhanced expression of high alkaline phosphatase activity, high rates of cell proliferation, and production of mineralized extracellular matrix. The enhancement may be due to the adsorption of a high quantity of fibronectin from the serum onto the reacted bioactive glass surface.

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Bone formation at a ceramic implant interface

Cited by 78 publications

References 8 publications

Vidrios y Vitrocerámicos Bioactivos

Vidrios y Vitrocerámicos Bioactivos

Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development

Porous bioactive glass and hydroxyapatite ceramic affect bone cell functionin vitro along different time lines

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