Bone formation with high bacterial inhibition and low toxicity behavior by melding of Al2O3 on nanobioactive glass ceramics via sol-gel process

Mubina, M. S. Kairon; Shailajha, S.; Sankaranarayanan, R.; Iyyadurai, M.

doi:10.1007/s10971-022-05842-9

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…In experimentation, the heavy element SeO 2 , having an atomic radius of 0.62 Å, was substituted against the lighter element SiO 2 with an atomic radius of 0.40 Å. Due to the excessive doping of the heavier element selenium, the density of the calcium silicate material has increased, resulting in improved compressive strength [57,58]. In another way, the reduced particle size was preferentially caused by an increased concentration of selenium oxide, which simultaneously created the agglomeration of heavy dopant material on the surface of the host material.…”

Section: Compressive Strength Analysismentioning

confidence: 99%

“…The L929 mammalian cell line was chosen based on the following factors: it is highly recommended due to its excellent sensitivity and simple culturing process. It also has the advantages of reliability and reproducibility [58]. Fibroblast cells initiated the wound-healing process and developed the extracellular matrix component via collagen production.…”

Section: In-vitro Cytotoxicity Assaymentioning

confidence: 99%

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Calcium silicate biocomposites: effects of selenium oxide on the physico-mechanical features and their in-vitro biological assessments

et al. 2023

Biomed. Mater.

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Bone tissue regenerative material serves as a prospective recovery candidate with self-adaptable biological properties of bio-activation, degradability, compatibility, and antimicrobial efficacy instead of metallic implants. Such materials are highly expensive due to chemical reagents and complex synthesis procedures, making them unaffordable for patients with financial constraints. This research produced an efficient bone tissue regenerative material using inexpensive naturally occurring source materials, including silica sand and limestone. The extracted SiO2 and CaO particles (75:25 wt%) were subjected to hydrothermal synthesis (water treatment instead of chemical solvents) to produce the CaSiO3 biomaterial (code: S). Selenium oxide was doped with calcium silicate at 3, 5, and 10 wt.% to enhance its properties, yielding biocomposite materials (i.e., S3, S5, and S10). The physico-mechanical properties of these materials were investigated with XRD, FTIR, FESEM-EDS, and micro-UTM. The results revealed that the synthesized biocomposites have a crystalline wollastonite phase with a porously fused rough surface. From structural parametric calculations, we found that the biocomposites have reduced particle size and enhanced surface area due to the influence of selenium oxide. The biocomposite S10, having high SeO2 content, attained the maximum compressive strength of 75.2 MPa. In-vitro studies of bioactivity, biodegradability, biocompatibility, and antibacterial activity were performed. At 7 and 14 days of bioactivity, the synthesized biocomposites are capable of dissolving their ions into SBF solution to precipitate HAp and a required Ca/P ratio of 1.69 was achieved by S3. A comparative analysis has been performed on the degradation activity in Tris-HCl and the consequent pH changes during SBF treatment. The bio-analysis revealed that the biocomposite S3 shows enhanced bioactivity through a controlled degradation rate and secured cell viability of 88% at a concentration of 100 μg/ml. It also offers significant bacterial inhibition potency against E.coli and S.aureus bacteria.

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Section: Compressive Strength Analysismentioning

confidence: 99%

Section: In-vitro Cytotoxicity Assaymentioning

confidence: 99%

Calcium silicate biocomposites: effects of selenium oxide on the physico-mechanical features and their in-vitro biological assessments

et al. 2023

Biomed. Mater.

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Co-doping of silicate bioceramics as a potential strategy to further enhance mono-doping consequences

Mofakhami,

Salahinejad

2024

Coordination Chemistry Reviews

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Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

Jiang,

Wang,

Feng

et al. 2024

Materials Science and Technology

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Hydroxyapatite (HA) has been wildly used in clinical practice for artificial implants. However, due to its inherent properties and preparation process, it is limited by low strength in practical applications. Therefore, highly porous hydroxyapatite scaffolds reinforced with 0 to 30 wt% doped wollastonite (WS) (HA/WS) were prepared by freeze-drying in combination with pressureless sintering method. The results demonstrated that WS could consistently improve the compressive properties of HA/WS scaffolds. The HA/WS scaffolds have optimal total porosity with good open pores and internal interconnections when the WS doping is 10%. In vitro osteoclast attachment experiments indicated that the HA/WS scaffolds had good biocompatibility. The findings of this study provide theoretical guidance for the application of HA in the field of artificial implants.

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Bone formation with high bacterial inhibition and low toxicity behavior by melding of Al2O3 on nanobioactive glass ceramics via sol-gel process

Cited by 4 publications

References 67 publications

Calcium silicate biocomposites: effects of selenium oxide on the physico-mechanical features and their in-vitro biological assessments

Calcium silicate biocomposites: effects of selenium oxide on the physico-mechanical features and their in-vitro biological assessments

Co-doping of silicate bioceramics as a potential strategy to further enhance mono-doping consequences

Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

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