Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Nyan, Myat; Sato, Daisuke; M, Oda; Machida, Tetsu; Kobayashi, Hiroshi; Nakamura, Takahiro J.; Kasugai, Shohei

doi:10.1254/jphs.sc0070184

Cited by 111 publications

(113 citation statements)

References 11 publications

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“…4 In the present study, the use of high local doses of simvastatin caused an intense inflammatory reaction, accompanied by tissue necrosis and scabbing. Soft tissue inflammation was also reported by Thylin et al, 6 who used 2.2 mg of the drug in methylcellulose gel in rat calvaria; by Nyan et al, 9 who used 1 mg of the drug in calcium sulfate in rat calvaria; and by Stein et al, 7 who used doses of 0.5, 1.0, 1.5, and 2.2 mg of the drug in rat mandible. In the study conducted by Stein et al, 7 the 0.5-mg dose presented the best cost-benefit ratio, promoting significant bone formation and reduced inflammation.…”

Section: Discussionmentioning

confidence: 63%

“…5,9,10 Others, however, have found no beneficial effects. 9,19,20 The ideal doses and carriers have yet to be determined, and the issue remains controversial. Low doses have no impact on bone repair, whereas high doses can stimulate inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 The results have often been encouraging. The purpose of the present study was to evaluate the influence of the association between simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Lima

Calixto

Anbinder³

2011

Braz. oral res.

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Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment with a combination of simvastatin solution (2.2 mg/50 µl) and DBBM (DBBMSIM-1); and treatment with simvastatin solution (0.5 mg/50 µl) and DBBM (DBBM-SIM-2). Animals were sacrificed on postoperative day 30 or 60, after which the calvariae were X-rayed and prepared for histomorphometric evaluation. The data were submitted to statistical analysis (p < 0.05). Xrays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and DBBM group samples. Histomorphometric analysis revealed that, on postoperative day 30, both DBBM and DBBMSIM-1 had a negative impact on bone formation. On postoperative day 60, none of the combinations tested impaired bone repair. These results showed that the association between DBBM and simvastatin had a negative impact on bone repair.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Lima

Calixto

Anbinder³

2011

Braz. oral res.

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“…Two studies have demonstrated that bilateral treatment of the posterolateral spine with rhBMP-2 resulted in complete spinal fusion in 100% of patients receiving the treatment. 9,73 The action of BMPs in vivo can even be enhanced by coadministration of NELL-1, 2 COX-2 inhibitors, 65 treatment with simvastatin, 86 or a combination of simvastatin and a-TCP. 85 Last, it is important to clarify that in Europe, rhBMP-2 is commercially available for the treatment of acute open tibial fractures (InductOS implant kit, Medtronic Sofamor Danek and Wyeth Pharmaceuticals) as a lyophilized powder, dissolved in sterile water, and applied to an absorbable collagen matrix made of Type 1 bovine collagen.…”

Section: Recombinant Protein-based Strategiesmentioning

confidence: 99%

Cranial bone defects: current and future strategies

Szpalski¹,

Barr²,

Wetterau³

et al. 2010

FOC

182

118

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Bony defects in the craniomaxillofacial skeleton remain a major and challenging health concern. Surgeons have been trying for centuries to restore functionality and aesthetic appearance using autografts, allografts, and even xenografts without entirely satisfactory results. As a result, physicians, scientists, and engineers have been trying for the past few decades to develop new techniques to improve bone growth and bone healing. In this review, the authors summarize the advantages and limitations of current animal models; describe current materials used as scaffolds, cell-based, and protein-based therapies; and lastly highlight areas for future investigation. The purpose of this review is to highlight the major scaffold-, cell-, and protein-based preclinical tools that are currently being developed to repair cranial defects.

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“…La materia prima de la que se hace es relativamente barata y abundante, se puede combinar con otros materiales como autoinjertos, aloinjertos, fosfatos de calcio, y vidrios bioactivos, para aumentar sus propiedades de unión, el volumen y la eficacia de los injertos óseos. También ha servido como un material de vehículo excelente para los factores de crecimiento y múltiples drogas, a pesar de estas ventajas, el material no ha gozado de la popularidad de muchos otros materiales de regeneración, aunque recientemente ha recibido una atención renovada con propiedades hemostáticas, angiogénicas y de barrera o membrana para la preservación de rebordes alveolares postexodoncias (1)(2)(3)(4)(5)(6)(7)(8) . …”

Section: Introductionunclassified

Sulfato de calcio: propiedades y aplicaciones clínicas

Lopez

Alarcón

2011

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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RESUMENDurante más de cien años el sulfato de calcio se ha distinguido de otros biomateriales, por ser uno de los materiales aloplásticos más simples y que presenta la más larga historia clínica como material sintético. Entre sus principales propiedades destacan que es de fácil obtención, capacidad de osteoconducción, es totalmente absorbible, no provoca reacciones de inflamación o antigénicas, fácil modelado y fuerza de compresión semejante al tejido óseo. Todas éstas características son necesarias para ser usado como sustituto óseo. Sin embargo, diferencias en la morfología y estructura de sus cristales, la porosidad, propiedades mecánicas y en la constitución química del sulfato de calcio puede alterar significativamente sus propiedades biológicas. El objetivo de la presente revisión es conocer las propiedades del sulfato de calcio y sus diferentes aplicaciones clínicas como sustituto óseo en procedimientos regenerativos. Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 4(3); 138-143, 2011.Palabras clave: Preservación del reborde, exodoncia, implantes dentales, injerto óseo, regeneración. ABSTRACTFor over 100 years, the calcium sulfate has stood out from other biomaterials, for being one of the simplest alloplastic materials and having the longest history as synthetic material. It is readily available, has osteoconductive properties, is completely absorbed, does not cause inflammation or antigenic reactions, can be modeled to defect, has compressive strength similar to bone tissue and can be used as a vehicle for in situ release of chemotherapeutic agents. All these features are required to be used as a bone substitute. However, differences in morphology, crystal structure, porosity, mechanical properties and chemical constitution of calcium sulfate can significantly alter its biological properties. The aim of this study was to determine through a review of the literature, the properties of calcium sulfate and its various clinical applications as bone substitute in regenerative procedures.

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Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Cited by 111 publications

References 11 publications

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Cranial bone defects: current and future strategies

Sulfato de calcio: propiedades y aplicaciones clínicas

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