Bone integration capability of a series of strontium‐containing hydroxyapatite coatings formed by micro‐arc oxidation

Yan, Jun; Sun, Jifeng; Chu, Paul K.; Han, Yong; Zhang, Yumei

doi:10.1002/jbm.a.34548

Cited by 87 publications

(63 citation statements)

References 50 publications

(125 reference statements)

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“…concentration may lead to different results of new bone formation and side effects, which meaning that the accumulation of Sr 2? should be paid attention to when applied to human [56,57]. The future study about the biocompatibility of different contents of Sr 2?…”

Section: Discussionmentioning

confidence: 98%

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

Liu

Cheng

Wahafu

et al. 2015

J Mater Sci: Mater Med

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The β-titanium alloy is thought to be a promising alloy using as orthopedic or dental implants owing to its characteristics, which contains low elastic modulus, high corrosion resistance and well biocompatibility. Our previous study has reported that a new β-titanium alloy Ti35Nb2Ta3Zr showed low modulus close to human bone, equal tissue compatibility to a traditional implant alloy Ti6Al4V. In this study, micro-arc oxidation (MAO) was applied on the Ti35Nb2Ta3Zr alloy to enhance its surface characteristics and biocompatibility and osseointegration ability. Two different coatings were formed, TiO2 doped with calcium-phosphate coating (Ca-P) and calcium-phosphate-strontium coating (Ca-P-Sr). Then we evaluated the effects of the MAO coatings on the Ti35Nb2Ta3Zr alloy through in vitro and in vivo tests. As to the characteristics of the coatings, the morphology, chemical composition, surface roughness and contact angle of MAO coatings were tested by scanning electron microscopy, energy dispersive spectroscopy, atomic force microscopy, and video contact-angle measurement system respectively. Besides, we performed MTT assay, ALP test and cell morphology-adhesion test on materials to evaluate the MAOed coating materials' biocompatibility in vitro. The in vivo experiment was performed through rabbit model. Alloys were implanted into rabbits' femur shafts, then we performed micro-CT, histological and sequential fluorescent labeling analysis to evaluate implants' osseointegration ability in vivo. Finally, the Ca-P specimens and Ca-P-Sr specimens exhibited a significant enhancement in surface roughness, hydrophilicity, cell proliferation, cell adhesion. More new bone was found around the Ca-P-Sr coated alloy than Ca-P coated alloy and Ti35Nb2Ta3Zr alloy. In conclusion, the MAO treatment improved in vitro and in vivo performance of Ti35Nb2Ta3Zr alloy. The Ca-P-Sr coating may be a promising modified surface formed by MAO for the novel β-titanium alloy Ti35Nb2Ta3Zr.

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Section: Discussionmentioning

confidence: 98%

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

Liu

Cheng

Wahafu

et al. 2015

J Mater Sci: Mater Med

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“…10 A recent study has shown that the osteoconductivity of 20% strontium-containing hydroxyapatite (SrHA) used as a coating on implant surfaces results not only in an acceleration but also an improvement in bone-implant integration. 11 There is evidence that strontium (Sr…”

mentioning

confidence: 99%

Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

et al. 2016

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The aim of this study is to evaluate the biocompatibility and osteoconductivity in surgical defects of sheep tibias filled with 1% strontium-containing nanostructured hydroxyapatite microspheres (SrHA), stoichiometric hydroxyapatite without strontium microspheres (HA), or blood clots. Santa Ines sheep were subjected to three perforations on the medial side of the left tibia. The biomaterials were characterized by X-ray Diffraction (XRD) and Fourier Transform Infrared (FTIR) before implantation and by X-Ray Microfluorescence (µFRX) and Scanning Electron Microscopy (SEM) after sheep tibias implantation. Surgical defects were filled with blood clots (control), SrHA (Group 1) or HA (Group 2). After 30 days, 5-µm bone blocks were obtained for histological evaluation, and the blocks obtained from 1 animal were embedded in methylmethacrylate for undecalcified sections. Mononuclear inflammatory infiltrate remained mild in all experimental groups. Giant cells were observed surrounding biomaterials particles of both groups and areas of bone formation were detected in close contact with biomaterials. All groups showed newly formed bone from the periphery to the center of the defects, which the control, HA and SrHA presented 36.4% (± 21.8), 31.2% (± 14.7) and 26.2% (± 12.9) of newly formed bone density, respectively, not presenting statistical differences. In addition, the connective tissue density did not show any significant between groups. The SrHA showing a higher volume density of biomaterial (51.2 ± 14.1) present in the defect compared to HA (32.6 ± 8.5) after 30 days (p = 0.03). Microspheres containing 1% SrHA or HA can be considered biocompatible, have osteoconductive properties and may be useful biomaterials for clinical applications.

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“…Park et al 35 (2015) e Yan et al 36 (2013) mostraram que os implantes de Ti recobertos com plasma spray de hidroxiapatita apresentavam maiores quantidade de osso na interface osso/implante, quando comparados a implantes com superfície lisa.…”

Section: Discussionunclassified

Tratamento de superfície em implantes dentários: uma revisão de literatura

Silva

Rodrigues

Pamato

et al. 2016

Rev. da Fac. de Odontologia, UPF

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IntroduçãoEm 1954, Branemark descobriu, indiretamente, por meio de seu clássico estudo que verificava a circulação sanguínea em tíbias de coelhos, o que chamou de osseointegração. Isso permitiu pesquisas posteriores em modelos animais, levando a resultados que possibilitaram o tratamento do edentulismo, por meio de próteses conectadas aos implantes dentários 1 . O processo de osseointegração é determinante para a obtenção do sucesso nas reabilitações proté-ticas de rebordos total ou parcialmente edêntulos, utilizando implantes dentários. O contato direto e estável entre o implante e o osso circundante determina esse sucesso 2 . A osseointegração efetiva é dependente de características como forma do implante (macroscópica e microscópica), qualidade do titânio, superfície e sua interação químico-biológica com o tecido ósseo. Essa análise guiará escolhas clínicas adequadas, propiciando melhor qualidade e rapidez à osseointegração [3][4][5] . A capacidade de osseointegração dos implantes está intimamente ligada a uma densa e resistente película de filme de óxido na superfície do implante, que é formada, espontaneamente, quando o titânio entra em contato com o ar ou com os fluidos fisiológicos, substância responsável pela proteção do titânio contra corrosão e oxidação 6 . A espessura e a

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Bone integration capability of a series of strontium‐containing hydroxyapatite coatings formed by micro‐arc oxidation

Cited by 87 publications

References 50 publications

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation

Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

Tratamento de superfície em implantes dentários: uma revisão de literatura

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