Bone Marrow and Peripheral Blood Cells Toxicity of a Single 2.0 Gy Cobalt60 Ionizing Radiation: An Animal Model

Akeem, Shittu; Lukman, Olatunbosun; Eltahir, Khalil; Fatai, Olalere; Abiola, Babatunde; Khadijat, Omokanye

doi:10.4314/ejhs.v29i2.6

Cited by 8 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bone marrow is extremely vulnerable to damage caused by RT. In a previous study, a significant decrease in lymphocyte counts was observed on days 14 and 21 after whole-body irradiation in guinea pigs ( 28 ). This is an effect of total-body irradiation, and the distribution and dynamics of lymphocytes in the body must be considered.…”

Section: Discussionmentioning

confidence: 75%

Association between unintentional splenic radiation and lymphopenia and high neutrophil/lymphocyte ratio after radiotherapy in patients with esophageal cancer

Sakaguchi¹,

Maebayashi²,

Aizawa³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background: Unintentional irradiation of the spleen may reduce absolute lymphocyte count (ALC), which can affect tumor immunity. Therefore, in the present study, we evaluated spleen dose-volume parameters associated with ALC and neutrophil/lymphocyte ratio (NLR) in patients with esophageal cancer.Methods: This retrospective study evaluated patients who were diagnosed with stage I-IV esophageal cancer and who received radiotherapy at Nihon University Itabashi Hospital between January 2015 and March 2020. Spleen V5, V10, V20, and V30 and mean spleen dose, which are dose-volume histogram parameters correlated with ALC and NLR, were analyzed.Results: In total, 89 esophageal cancer patients with a median age of 72 years (range, 51-92 years) were included in this research. Results showed that spleen V5, V10, and V20 and mean splenic dose were significantly correlated with a low ALC. Meanwhile, a significant association was observed between spleen V5 and V10 and a high NLR (P<0.05). In the linear regression analysis, spleen V5 and V10 were remarkably associated with a low ALC (P=0.006 and 0.008). Further, a correlation was noted between spleen V5 and a high NLR (P=0.019). Spleen V5 and V10 were remarkably associated with greater than grade 3 lymphopenia (P=0.024 and P=0.031).Conclusions: A correlation was observed between the irradiated volume of the spleen and ALC and NLR in patients with esophageal cancer. Furthermore, the spleen should be regarded as a high-risk organ, and the use of techniques in reducing spleen V5, V10 for the preservation of tumor immunity may be beneficial.

show abstract

Section: Discussionmentioning

confidence: 75%

Association between unintentional splenic radiation and lymphopenia and high neutrophil/lymphocyte ratio after radiotherapy in patients with esophageal cancer

Sakaguchi¹,

Maebayashi²,

Aizawa³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…IR affects hematopoietic tissues, and significantly reduces the number of neutrophils and platelets. The resulting decrease in the number of peripheral blood cells can cause sepsis, bleeding, anemia and, in some cases, death ( 126 ). Therefore, radiation therapeutics aim to promote the recovery of hematopoietic function.…”

Section: Strategies To Reduce Radiation Injurymentioning

confidence: 99%

Radioprotective countermeasures for radiation injury (Review)

Liu

Liang

et al. 2023

Mol Med Rep

View full text Add to dashboard Cite

A series of physiological and pathological changes occur after radiotherapy and accidental exposure to ionizing radiation (IR). These changes cause serious damage to human tissues and can lead to death. Radioprotective countermeasures are radioprotective agents that prevent and reduce IR injury or have therapeutic effects. Based on a good understanding of radiobiology, a number of protective agents have achieved positive results in early clinical trials. The present review grouped known radioprotective agents according to biochemical categories and potential clinical use, and reviewed radiation countermeasures, i.e., radioprotectors, radiation mitigators and radiotherapeutic agents, with an emphasis on their current status and research progress. The aim of the present review is to facilitate the selection and application of suitable radioprotectors for clinicians and researchers, to prevent or reduce IR injury.

show abstract

“…Ionizing radiation promotes the suppression of immunity and subsequent bone marrow depression ( Figure 1B ) ( 115 ). Within first 24 hours after irradiation, active apoptotic death of hematopoietic cells results in monocytopenia ( 116 ).…”

Section: Effects Of Treatment On Circulating Monocytesmentioning

confidence: 99%

Monocyte programming by cancer therapy

et al. 2022

View full text Add to dashboard Cite

Monocytes in peripheral blood circulation are the precursor of essential cells that control tumor progression, that include tumor-associated macrophages (TAMs), dendritic cells (DCs) and myeloid-derive suppressor cells (MDSC). Monocytes-derived cells orchestrate immune reactions in tumor microenvironment that control disease outcome and efficiency of cancer therapy. Four major types of anti-cancer therapy, surgery, radiotherapy, chemotherapy, and most recent immunotherapy, affect tumor-associated macrophage (TAM) polarization and functions. TAMs can also decrease the efficiency of therapy in a tumor-specific way. Monocytes is a major source of TAMs, and are recruited to tumor mass from the blood circulation. However, the mechanisms of monocyte programming in circulation by different therapeutic onsets are only emerging. In our review, we present the state-of-the art about the effects of anti-cancer therapy on monocyte progenitors and their dedifferentiation, on the content of monocyte subpopulations and their transcriptional programs in the circulation, on their recruitment into tumor mass and their potential to give origin for TAMs in tumor-specific microenvironment. We have also summarized very limited available knowledge about genetics that can affect monocyte interaction with cancer therapy, and highlighted the perspectives for the therapeutic targeting of circulating monocytes in cancer patients. We summarized the knowledge about the mediators that affect monocytes fate in all four types of therapies, and we highlighted the perspectives for targeting monocytes to develop combined and minimally invasive anti-cancer therapeutic approaches.

show abstract

Bone Marrow and Peripheral Blood Cells Toxicity of a Single 2.0 Gy Cobalt60 Ionizing Radiation: An Animal Model

Cited by 8 publications

References 27 publications

Association between unintentional splenic radiation and lymphopenia and high neutrophil/lymphocyte ratio after radiotherapy in patients with esophageal cancer

Association between unintentional splenic radiation and lymphopenia and high neutrophil/lymphocyte ratio after radiotherapy in patients with esophageal cancer

Radioprotective countermeasures for radiation injury (Review)

Monocyte programming by cancer therapy

Contact Info

Product

Resources

About