Bone marrow blood vessels: normal and neoplastic niche

Shahrabi, Saeid; Rezaeeyan, Hadi; Ahmadzadeh, Ahmad; Shahjahani, Mohammad; Saki, Najmaldin

doi:10.4081/oncol.2016.306

Cited by 8 publications

(11 citation statements)

References 95 publications

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“…Arterial vessels with less permeability are capable of maintaining HSCs in a resting state. On the other hand, higher-permeability sinusoids promote HSCs and progenitor cells and, therefore, alterations in these microenvironments may be related to hematological abnormalities [ 96 , 101 , 102 ]. It is unknown how Mg 2+ influences endothelial cells from bone marrow.…”

Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue.

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Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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“…An important player in the pathogeny of most tumors is the vascular niche (10), responsible for increased output of growth factors, such as VEGF (vascular endothelial growth factor) and FGFb, that promote uncontrolled cell growth. An association between angiogenesis and prognostics of MF has been well established (11–13) and repeated attempts have been made to target it therapeutically (14,15).…”

Section: Overview On Cutaneous T-cell Lymphomamentioning

confidence: 99%

Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)

et al. 2018

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Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF-VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo-vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro-angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets.

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“…The bone marrow microenvironment is a complex, highly vascular tissue. Hematopoietic cells in the marrow are derived from hematopoietic stem cells, while nonhematopoietic stromal cells are derived from mesenchymal stem cells (1,2).…”

Section: Introductionmentioning

confidence: 99%

Support of acute lymphoblastic leukemia cells by nonmalignant bone marrow stromal cells

et al. 2019

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The present report describes work examining the manner in which nonmalignant bone marrow stromal cells prevent acute lymphoblastic leukemia (ALL) cell death. The initial focus was on the role of stromal cell-derived C-X-C motif chemokine 12 (CXCL12). Interference with CXCL12 production by stroma or blockade of its interactions with ALL by plerixafor did increase ALL cell death and in sensitive ALLs there was synergistic effect with conventional chemotherapy drugs. However, in contrast to most reports, there was considerable heterogeneity regarding the effect between 7 unique primary ALLs, with several exhibiting no sensitivity to CXCL12 blockade. The diversity in effect was not explained by differences in the expression of ALL cell surface receptors for CXCL12. The modest and variable effects of interference with CXCL12 on ALL led to the assessment of gene expression profiles of stromal cells and ALL cells. Gene set enrichment analysis identified pathways associated with metabolism and redox reactions as potentially important in the stromal cell: leukemia cell interaction. Exploratory imaging studies demonstrated bidirectional transfer of intracellular calcien-labelled molecules and also bidirectional transfer of mitochondria between stromal cells and ALL cells, providing potential means of metabolic interdependence of stromal cells and ALL cells.

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Bone marrow blood vessels: normal and neoplastic niche

Cited by 8 publications

References 95 publications

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)

Support of acute lymphoblastic leukemia cells by nonmalignant bone marrow stromal cells

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