Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Zhang, Yi; Wang, Fuyou; Chen, Jia‐Rong; Ning, Zhigang; Yang, Liu

doi:10.1007/s00264-011-1362-z

Cited by 38 publications

(32 citation statements)

References 25 publications

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“…Various cell types and materials were tested in the studies. Zhang et al compared bone marrow-derived MSC and uncultured bone marrowderived nucleated cells (bone marrow concentrate) in a pig model and reported that the results of both groups were comparable [40]. The results of this study seem to support the feasibility of a one-step procedure in a clinical setting.…”

Section: Large Animal Studiessupporting

confidence: 68%

“…Among those, a (mini)pig model has been most frequently employed in previous studies [37][38][39][40][41][42][43][44]. Various cell types and materials were tested in the studies.…”

Section: Large Animal Studiesmentioning

confidence: 99%

“…With the intent of evaluation with models that is more relevant to clinical condition in humans, large animals such as pig and sheep have been used as experimental subjects [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]. Among those, a (mini)pig model has been most frequently employed in previous studies [37][38][39][40][41][42][43][44].…”

Section: Large Animal Studiesmentioning

confidence: 99%

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Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.

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Section: Large Animal Studiessupporting

confidence: 68%

“…Among those, a (mini)pig model has been most frequently employed in previous studies [37][38][39][40][41][42][43][44]. Various cell types and materials were tested in the studies.…”

Section: Large Animal Studiesmentioning

confidence: 99%

Section: Large Animal Studiesmentioning

confidence: 99%

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Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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“…Moreover, in contrast to mature chondrocytes, MSCs can be expanded ex vivo to sufficiently high numbers, making them an abundant cell source for autologous cell therapies. Unfortunately, it is difficult to obtain a pure population of stem cells, as well as precisely control the direction of MSC differentiation [61]. Another disadvantage is the relatively low percentage of MSCs in bone marrow; moreover, in the elderly, the cell proliferation rate of isolated MSCs is often insufficient.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Augustyniak

Trzeciak

Richter

et al. 2014

International Orthopaedics (SICOT)

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Purpose The use of stem cells in regenerative medicine offers hope to treat numerous orthopaedic disorders, including articular cartilage defects. Although much research has been carried out on chondrogenesis, this complicated process is still not well understood and much more research is needed. The present review provides an overview of the stages of chondrogenesis and describes the effects of various growth factors, which act during the multiple steps involved in stem celldirected differentiation towards chondrocytes. Methods The current literature on stem cell-directed chondrogenesis, in particular the role of members of the transforming growth factor-β (TGF-β) superfamily-TGF-βs, bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs)-is reviewed and discussed. Results Numerous studies have reported the chondrogenic potential of both adult-and embryonic-like stem cells and the role of growth factors in programming differentiation of these cells towards chondrocytes. Mesenchymal stem cells (MSCs) are adult multipotent stem cells, whereas induced pluripotent stem cells (iPSC) are reprogrammed pluripotent cells. Although better understanding of the processes involved in the development of cartilage tissues is necessary, both cell types may be of value in the clinical treatment of cartilage injuries or osteoarthritic cartilage lesions. Conclusions MSCs and iPSCs both present unique characteristics. However, at present, it is still unclear which cell type is most suitable in the treatment of cartilage injuries.

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“…The composition of these nucleated cells is diverse that includes MSCs, Hematopoietic Stem Cells (HSCs), Monocyte Precursor cells, Macrophages, T cells, B cells, Dendritic Antigen Presenting Cells, Natural Killer Cells and Neutrophils. [77][78][79] Nevertheless, BMC serves as a source of growth factors, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and bone morphogenetic protein (BMP)-2 and BMP-7, which are assigned to have anabolic and anti-inflammatory effects that facilitate regeneration of tissue. [80][81][82] The resultant BMC after centrifugation has been shown to provide elevated levels of HSCs, MSCs, platelets, chemokines and cytokines that are injected intra-articularly for treating cartilage defects.…”

mentioning

confidence: 99%

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Venkatesh¹

2017

ATROA

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Abbreviations: ACI, autologous chondrocyte implantation;MSCs, mesenchymal stem cells; PRP, platelet-rich plasma; BMC, autologous bone marrow concentrate; TKR, total knee replacement IntroductionOsteoarthritis is a form of arthritis described as a degenerative joint disease that results from the breakdown of articular cartilage and underlying subchondral bone.1,2 Cartilage is firm, rubbery, protein substance that serves as a "cushion" between the bones, providing a smooth, gliding surface for joint motion. As the cartilage breaks down, it causes pain, swelling, stiffness and problems moving the joint.3 Therefore, Osteoarthritis is a chronic disease and a major cause of disability, characterized by irreversible cartilage degeneration, bony changes of the joints, deterioration of tendons and ligaments, and inflammation of the synoviumas shown in Figure 1. 4 An initial degeneration, known as the 'pre-OA' state may be reversible spontaneously or through preventive measures, however, if not stopped, the disease progresses to later stages which results in loss of articular cartilage surface integrity, break down of bone and osteophyte formation.3,5 OA can affect any joint, but it most often occurs in the knee, hip, lower back and neck, small joints in the finger and base of the big toe ( Figure 2). 6,7Osteoarthritis of the knee is the most common chronic condition affecting all races, gender and ages, but known to be the most common in elderly and obese people. 8,9 The knee acts as a conduit for transferring body weight essential for normal human mobility and the menisci is known to maintain the normal function of the knee, distribute load, lubricate the joint and provide joint stability. Injury to the meniscus from ageing cartilage, repetitive activity or trauma results in pain, limits movement and can accelerate the occurrence and development of OA. In general, partial or complete meniscectomy causes OA of the knee. 8,10,11 While the prevalence of OA increases with age and causes significant decline in the quality of life of individuals above the age of 65, there is increasing evidence of OA in younger population as a result of prior injuries such as anterior cruciate ligament tear or meniscal tears. 8,12,13 Figure 1 Comparison schematic between healthy knee and arthritic knee.Osteoarthritis affects about 237 million of the population, of which an estimated 9 million people alone in United States suffer from symptomatic knee osteoarthritis and it is predicted that an additional 19 million people will be affected by arthritis by 2020. 14-17The incidence of chondral defects is frequent with sporting injuries, and in elderly patients specifically 10% of population over the age of 55 years have troublesome knee pain, and of those, 25% are severely disabled.18 Depending on disease severity, management ranges from conservative treatment to surgical intervention, including total knee replacement. 14,19 In recent years the number and cost of TKR has increased dramatically between 2001 and 2012 from 305,000 to 610,000 procedu...

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Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Cited by 38 publications

References 25 publications

Cartilage repair techniques in the knee: stem cell therapies

Cartilage repair techniques in the knee: stem cell therapies

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

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