Bone marrow-derived mesenchymal stem cells expressing the Shh transgene promotes functional recovery after spinal cord injury in rats

Jia, Yijia; Wu, Dou; Zhang, Ruiping; Shuang, Weibing; Sun, Jiping; Hao, Huang; An, Qijun; Liu, Qiang

doi:10.1016/j.neulet.2014.05.010

Cited by 33 publications

(18 citation statements)

References 20 publications

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“…Among various biological strategies, cell-based gene delivery is an attractive option for treatment of moderate degenerative disc disease. [16][17][18] In this study, we injected rAAV-hTERTmodified NPCs into a canine disc degenerative animal model to investigate the efficacy of hTERT in disc degeneration treatment.…”

Section: Discussionmentioning

confidence: 99%

Intervention of rAAV-hTERT-Transducted Nucleus Pulposus Cells in Early Stage of Intervertebral Disc Degeneration: A Study in Canine Model

Shi

Xin

et al. 2015

Tissue Engineering Part A

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Section: Discussionmentioning

confidence: 99%

Intervention of rAAV-hTERT-Transducted Nucleus Pulposus Cells in Early Stage of Intervertebral Disc Degeneration: A Study in Canine Model

Shi

Xin

et al. 2015

Tissue Engineering Part A

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“…MSCs have been demonstrated to promote axonal regeneration and suppress demyelination [100] . Several different studies in rat models found that MSCs induce nerve regeneration, modulate the production of inflammatory cytokines such as TNF-α and IL-6 and reduce myeloperoxidase activity [101][102][103][104][105] . Menezes et al [106] hypothesized that laminin may play a pivotal role in neuron and axon preservation and regeneration after finding deposits of the glycoprotein on the lesion site …”

Section: Resultsmentioning

confidence: 99%

Stem cells for spine surgery

Schroeder

Kueper

Kaplan

et al. 2015

WJSC

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In the past few years, stem cells have become the focus of research by regenerative medicine professionals and tissue engineers. Embryonic stem cells, although capable of differentiating into cell lineages of all three germ layers, are limited in their utilization due to ethical issues. In contrast, the autologous harvest and subsequent transplantation of adult stem cells from bone marrow, adipose tissue or blood have been experimentally utilized in the treatment of a wide variety of diseases ranging from myocardial infarction to Alzheimer's disease. The physiologic consequences of stem cell transplantation and its impact on functional recovery have been studied in countless animal models and select clinical trials. Unfortunately, the bench to bedside translation of this research has been slow. Nonetheless, stem cell therapy has received the attention of spinal surgeons due to its potential benefits in the treatment of neural damage, muscle trauma, disk degeneration and its potential contribution to bone fusion.

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“…Engineered BM-MSCs secreting Shh enhanced VEGF expression in the injured area, thereby causing an improvement in the local microenvironment and leading to enhanced functional recovery [232].…”

Section: Mscs In Neural Differentiation and Repairmentioning

confidence: 99%

“…ecSOD [158] GLP-1 [160] HCN1 [19] HCN4 [186,187] Fn14 [189] Wnt11 [164] HO-1 [167,168] My GA NEURAL DIFFERENTIATION AND REPAIR BDNF [22] [201] [203,204] GDNF [20] [207] [216,217] NGF [236] NT-3 [225,226] MNTS-1 [230] Shh [232] VEGF [21] GLP-1 [215] VIP [221] IL-10 [222] interferon-β [223] CXCR4 [205] TrkC [228] Ng Ng RA Nu Ma KIDNEY REPAIR HGF [23] GSTM1 [267] Survivin [268] …”

Section: Cartilage Productionmentioning

confidence: 99%

Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine

Nowakowski

Walczak

Janowski

et al. 2015

Stem Cells and Development

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Mesenchymal stem cells (MSCs), which can be obtained from various organs and easily propagated in vitro, are one of the most extensively used types of stem cells and have been shown to be efficacious in a broad set of diseases. The unique and highly desirable properties of MSCs include high migratory capacities toward injured areas, immunomodulatory features, and the natural ability to differentiate into connective tissue phenotypes. These phenotypes include bone and cartilage, and these properties predispose MSCs to be therapeutically useful. In addition, MSCs elicit their therapeutic effects by paracrine actions, in which the metabolism of target tissues is modulated. Genetic engineering methods can greatly amplify these properties and broaden the therapeutic capabilities of MSCs, including transdifferentiation toward diverse cell lineages. However, cell engineering can also affect safety and increase the cost of therapy based on MSCs; thus, the advantages and disadvantages of these procedures should be discussed. In this review, the latest applications of genetic engineering methods for MSCs with regenerative medicine purposes are presented.

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Bone marrow-derived mesenchymal stem cells expressing the Shh transgene promotes functional recovery after spinal cord injury in rats

Cited by 33 publications

References 20 publications

Intervention of rAAV-hTERT-Transducted Nucleus Pulposus Cells in Early Stage of Intervertebral Disc Degeneration: A Study in Canine Model

Intervention of rAAV-hTERT-Transducted Nucleus Pulposus Cells in Early Stage of Intervertebral Disc Degeneration: A Study in Canine Model

Stem cells for spine surgery

Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine

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