Bone Marrow Examination in Patients of Cytopenia - A Study on Clinical and Etiological Profile

Abstract

Introduction: Bone marrow examination is an important diagnostic tool and the cornerstone of hematology. Cytopenia is a descriptive term referring to a reduction in any of the three blood cell lineage erythrocytes, leukocytes and platelets. This study aimed toAims And Objectives: determine the clinical and etiological prole in patients of cytopenias undergone bone marrow examination. it was aMaterial And Methods: prospective observational hospital based study conducted over a period of 18 months (July 2016 to January 2018) in the department of Pathology, Krishna Institute of Medical Science, Secunderabad. Complete history, physical examination, complete blood count, peripheral blood lm and bone marrow aspiration was done in 400 patients who presented with cytopenias. Out of 400 patients, 208 cases were male and 192 wereResults: females with Male: female ratio 1.08:1. Age ranging from 1 to 87 years with mean age of patient's was 43.5 years. Out of 400 patients of cytopenia 167 cases were neoplastic and 226 cases were non-neoplastic while 7 cases showed normal marrow ndings. Findings in these cases included megaloblastic anemia, acute leukemia, immune thrombocytopenic purpura, and plasma cell myeloma as the commonest cause of pancytopenia, bicytopeia, thrombocytopenia and anemia respectively. Bone marrow evaluation is an important and effective tool in diagnosing andConclusion: evaluating hematological disorders.