Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study

Yusup, A.; Kaneko, Haruka; Liu, L.; Liang, Ning; Sadatsuki, R.; Hada, S.; Kamagata, Koji; Kinoshita, M.; Futami, I.; Shimura, Yukio; Tsuchiya, Masaharu; Saita, Yoshitomo; Takazawa, Yuji; Ikeda, Hiroshi; Aoki, Shigeki; Kaneko, Kazuo; Ishijima, Muneaki

doi:10.1016/j.joca.2015.05.017

Cited by 55 publications

(38 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16) [55]. Although synovial COX-2, IL-1b or IL-6 expression levels were not associated with the HSS, the synovial TGF-b expression levels were associated with the HSS (data not shown) [55]. These data suggest that synovitis is present not only in early-stage, but also end-stage knee OA and is possibly induced by articular cartilage destruction and, at least in part, subchondral pathologies.…”

Section: Early-to Middle-stage Knee Oamentioning

confidence: 89%

“…15 Correlation between the expression levels of inflammatory mediators and growth factor in the medial perimeniscal synovial tissue and the radiographic parameters and patient-oriented outcome measures for knee OA in patients [54]. According to our results, we further examined the OArelated structural changes associated with histological synovitis in end-stage knee OA patients [55]. Among the seven OA-related structural changes evaluated using the whole-organ MRI scoring (WORMS) method, such as cartilage morphology, subchondral bone marrow lesion (BML), subchondral bone cyst (SBC), subchondral bone attrition (SBA), osteophytes, meniscal lesion, and synovitis, the BML, SBC, SBA, and synovitis were significantly associated with the histological synovitis score (HSS) (r = 0.33, 0.35, 0.48, and 0.36, respectively), while other morphological changes were not (Table 7, Fig.…”

Section: Early-to Middle-stage Knee Oamentioning

confidence: 94%

“…The expression levels of MMP-1, COX-2, and IL-1b in both the lining and sublining layers of the medial perimeniscal synovial tissue showed a significant negative correlation with the JKOM score of the patients. The expression levels of TGF-b in the sublining layer of the medial perimeniscal synovial tissue in the patients Table 7 Correlation between the total histological synovitis score (HSS) and the whole-organ magnetic resonance imaging score (WORMS) in patients with end-stage knee OA receiving TKA [55] MRI-detected OA pathologies HSS Fig. 14 A simple regression analysis comparing the histological and enhanced MRIevaluated synovitis score with the JKOM score in patients with end-stage knee OA [53].…”

Section: Early-to Middle-stage Knee Oamentioning

confidence: 99%

“…Among the seven OA-related structural changes evaluated using the whole-organ MRI scoring (WORMS) method, such as cartilage morphology, subchondral bone marrow lesion (BML), subchondral bone cyst (SBC), subchondral bone attrition (SBA), osteophytes, meniscal lesion, and synovitis, the BML, SBC, SBA, and synovitis were significantly associated with the histological synovitis score (HSS) (r = 0.33, 0.35, 0.48, and 0.36, respectively), while other morphological changes were not (Table 7, Fig. 16) [55]. Although synovial COX-2, IL-1b or IL-6 expression levels were not associated with the HSS, the synovial TGF-b expression levels were associated with the HSS (data not shown) [55].…”

Section: Early-to Middle-stage Knee Oamentioning

confidence: 99%

“…Association between the HSS and the BML score (a), SBC score (b), and SBA score (c) in patients with end-stage knee OA receiving TKA[55]. The sagittal T2-weighted MR image (d-f) and the histological sections (g-i) of three representative cases (J, K and L, respectively) show the presence of BML, SBC, and SBA.J Cartilage loss in MFc (arrow with head), MTc, MFa, MTa, MFp, and MTp, BML in MTa and MFc (arrowhead), SBC in MFc (thin arrow), SBA in MTc (thick arrow), osteophyte in MFa (open arrow head), MFp, MTa, and MTp, meniscus in the medial meniscus (open arrow).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Ishijima

Kaneko

Hada

et al. 2016

Clinic Rev Bone Miner Metab

View full text Add to dashboard Cite

Locomotive syndrome'' is defined as a condition associated with restriction in one's ability to walk or lead a normal life due to a dysfunction in one or more of the parts of the locomotion system, including the muscles, bones, joints, cartilage or intervertebral discs. This syndrome especially refers to individuals who have come to need nursing care services because of problems with the locomotive organs, or those who have conditions which may require them to need such services in the near future. Recent epidemiological studies revealed that the one-fourth of elderly individuals who require special assistance or nursing care have locomotive disorders in Japan. Osteoarthritis of the knee (knee OA) and hip (hip OA), and osteoporosis and spinal canal stenosis due to spondylosis are three major locomotive disorders that cause elderly individuals require special assistance or nursing care. In this review, we focus on the effects of knee and hip OA on the lives of elderly individuals and the recent advantages in clinical research on the pathophysiology and management of these diseases.

show abstract

Section: Early-to Middle-stage Knee Oamentioning

confidence: 89%

Section: Early-to Middle-stage Knee Oamentioning

confidence: 94%

Section: Early-to Middle-stage Knee Oamentioning

confidence: 99%

Section: Early-to Middle-stage Knee Oamentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Ishijima

Kaneko

Hada

et al. 2016

Clinic Rev Bone Miner Metab

View full text Add to dashboard Cite

show abstract

Association of Knee Effusion Detected by Physical Examination With Bone Marrow Lesions: Cross‐Sectional and Longitudinal Analyses of a Population‐Based Cohort

Cibere

Guermazi

Nicolaou

et al. 2018

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

Magnetic Resonance Imaging–Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study

Perry

O’Neill

Tolstykh

et al. 2021

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective. To examine whether knee subchondral cysts, measured on magnetic resonance imaging (MRI), are associated with incident knee osteoarthritis (OA) outcomes.Methods. We used longitudinal data from the Multicenter Osteoarthritis Study, a community-based cohort of subjects with risk factors for knee OA. Participants without a history of knee surgery and/or inflammatory arthritis (i.e., rheumatoid arthritis and gout) were followed up for 84 months for the following incident outcomes: 1) radiographic knee OA (Kellgren/Lawrence grade ≥2), 2) symptomatic radiographic knee OA (radiographic knee OA and frequent knee pain), and 3) frequent knee pain (with or without radiographic knee OA). In a subset of participants, subchondral cysts were scored on baseline MRIs of 1 knee. Multiple logistic regression, with adjustment for participant characteristics and other baseline knee MRI findings, was used to assess whether subchondral cysts were predictive of incident outcomes.Results. Among the participants with knees eligible for analyses of outcomes over 84 months, incident radiographic knee OA occurred in 22.8% of knees with no baseline radiographic knee OA, symptomatic radiographic knee OA occurred in 17.0% of knees with no baseline symptomatic radiographic knee OA, and frequent knee pain (with or without radiographic knee OA) occurred in 28.8% of knees with no baseline radiographic knee OA and 43.7% of knees with baseline radiographic knee OA. With adjustment for age, sex, and body mass index, the presence of subchondral cysts was not associated with incident radiographic knee OA but was associated with increased odds of incident symptomatic radiographic knee OA (odds ratio 1.92 [95% confidence interval 1.16-3.19]) and increased odds of incident frequent knee pain in those who had radiographic knee OA at baseline (odds ratio 2.11 [95% confidence interval 0.87-5.12]). Stronger and significant associations were observed for outcomes based on consistent reports of frequent knee pain within ~1 month of the study visit.Conclusion. Subchondral cysts are likely to be a secondary phenomenon, rather than a primary trigger, of radiographic knee OA, and may predict symptoms in knees with existing disease.The views expressed herein are those of the authors alone and not necessarily those of the NHS, the NIHR,

show abstract

Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study

Abstract: The presence of BML, SBC and SBA was associated with histological synovitis in end-stage knee OA patients.

Cited by 55 publications

References 37 publications

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Association of Knee Effusion Detected by Physical Examination With Bone Marrow Lesions: Cross‐Sectional and Longitudinal Analyses of a Population‐Based Cohort

Magnetic Resonance Imaging–Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study

Contact Info

Product

Resources

About