Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

Farashah, Mohammad Sadegh Gholami; Mohammadi, Amir Hossein; Javadi, Maryam; Rad, Jafar Soleimani; Shakouri, Seyed Kazem; Meshgi, Shahla; Roshangar, Leila

doi:10.1007/s10561-022-10066-w

Cited by 4 publications

(2 citation statements)

References 114 publications

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“…Compared with hucMSCs and ADMSCs, BMMSCs have high potency for clinical use in the treatment of various diseases (e.g., bone and cartilage, immune system, nervous system, cardiovascular, viral/infectious, cancer, wounds and injuries). The exosomes produced by BMMSCs can also be utilized for this purpose ( 174 , 175 ). Compared with BMMSCs, BMMSCs-derived exosome (BMMSCs-Exo) have smaller volume, are associated with less immune rejection, and can easily transport therapeutic agents, thus playing a great role in overcoming resistance to cancer treatment ( Figure 3 ).…”

Section: Mscs-derived Exosomes (Mscs-exo) In Cancer Therapymentioning

confidence: 99%

Different origin-derived exosomes and their clinical advantages in cancer therapy

Jin,

Zhang,

Zhang

et al. 2024

Front. Immunol.

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Exosomes, as a class of small extracellular vesicles closely related to the biological behavior of various types of tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding cancer diagnosis, the stability of their membrane structure and their wide distribution in body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor diagnosis in the future. For cancer treatment, exosomes, as the “golden communicators” between cells, can be designed to deliver different drugs, aiming to achieve low-toxicity and low-immunogenicity targeted delivery. Signaling pathways related to exosome contents can also be used for safer and more effective immunotherapy against tumors. Exosomes are derived from a wide range of sources, and exhibit different biological characteristics as well as clinical application advantages in different cancer therapies. In this review, we analyzed the main sources of exosomes that have great potential and broad prospects in cancer diagnosis and therapy. Moreover, we compared their therapeutic advantages, providing new ideas for the clinical application of exosomes.

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Section: Mscs-derived Exosomes (Mscs-exo) In Cancer Therapymentioning

confidence: 99%

Different origin-derived exosomes and their clinical advantages in cancer therapy

Jin,

Zhang,

Zhang

et al. 2024

Front. Immunol.

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“…Mesenchymal stem cells (MSCs) are among the highly investigated cell sources for regenerative medicine and tissue engineering applications [ 9 , 10 ]. They can be obtained from diverse adult tissues originating from the mesodermal layer of embryos including but not limited to adipose tissue, bone marrow, umbilical cord blood, dental pulp, periosteum, muscle tissues, and periodontal ligament [ 11 , 12 , 13 ]. MSCs present various unique properties such as plastic adherent growth, high proliferation capacity, outstanding ability to differentiate into various cell lineages, and the expression of multiple cell surface markers [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Adipose Tissue Depot Harvesting Site on the Multilineage Induction Capacity of Male Rat Adipose-Derived Mesenchymal Stem Cells: An In Vitro Study

El-Husseiny

Kaneda

Mady

et al. 2023

IJMS

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Recently, substantial attention has been paid toward adipose-derived mesenchymal stem cells (AdMSCs) as a potential therapy in tissue engineering and regenerative medicine applications. Rat AdMSCs (r-AdMSCs) are frequently utilized. However, the influence of the adipose depot site on the multilineage differentiation potential of the r-AdMSCs is still ambiguous. Hence, the main objective of this study was to explore the influence of the adipose tissue harvesting location on the ability of r-AdMSCs to express the stem-cell-related markers and pluripotency genes, as well as their differentiation capacity, for the first time. Herein, we have isolated r-AdMSCs from the inguinal, epididymal, peri-renal, and back subcutaneous fats. Cells were compared in terms of their phenotype, immunophenotype, and expression of pluripotency genes using RT-PCR. Additionally, we investigated their potential for multilineage (adipogenic, osteogenic, and chondrogenic) induction using special stains confirmed by the expression of the related genes using RT-qPCR. All cells could positively express stem cell marker CD 90 and CD 105 with no significant in-between differences. However, they did not express the hematopoietic markers as CD 34 and CD 45. All cells could be induced successfully. However, epididymal and inguinal cells presented the highest capacity for adipogenic and osteogenic differentiation (21.36-fold and 11.63-fold for OPN, 29.69-fold and 26.68-fold for BMP2, and 37.67-fold and 22.35-fold for BSP, respectively, in epididymal and inguinal cells (p < 0.0001)). On the contrary, the subcutaneous cells exhibited a superior potential for chondrogenesis over the other sites (8.9-fold for CHM1 and 5.93-fold for ACAN, (p < 0.0001)). In conclusion, the adipose tissue harvesting site could influence the differentiation capacity of the isolated AdMSCs. To enhance the results of their employment in various regenerative cell-based therapies, it is thus vital to take the collection site selection into consideration.

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Multifunctional Plga/Mg(Oh)2/Zn3(Po4)2 Composites with Antimicrobial and Osteogenic Properties

Wang,

Wu,

et al. 2024

Preprint

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Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

Cited by 4 publications

References 114 publications

Different origin-derived exosomes and their clinical advantages in cancer therapy

Different origin-derived exosomes and their clinical advantages in cancer therapy

Impact of Adipose Tissue Depot Harvesting Site on the Multilineage Induction Capacity of Male Rat Adipose-Derived Mesenchymal Stem Cells: An In Vitro Study

Multifunctional Plga/Mg(Oh)2/Zn3(Po4)2 Composites with Antimicrobial and Osteogenic Properties

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