2023
DOI: 10.1002/jbt.23568
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Bone marrow mesenchymal stem cells‐derived exosomes ameliorate LPS‐induced acute lung injury by miR‐223‐regulated alveolar macrophage M2 polarization

Hui Xu,
Xiangbi Nie,
Wu Deng
et al.

Abstract: Numerous studies have shown that the M2 polarization of alveolar macrophages (AM) plays a protective role in acute lung injury (ALI). Mesenchymal stem cells (MSCs) secreted exosomes have been reported to be involved in inflammatory diseases by the effects of polarized M1/M2 macrophage populations. However, whether bone marrow mesenchymal stem cells (BMMSCs) derived exosomes could protect from ALI and its mechanisms are still unclear. Here, we explored the role of exosomes from BMMSC in rat AM polarization and … Show more

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