Bone Marrow Oxalosis in a Patient With Pancytopenia Following Bilateral Nephrectomy

Kim, Moon Jin; Park, Pil Whan; Seo, Yiel Hea; Kim, Kyung Hee; Seo, Ja Young; Jeong, Ji Hun; Lee, Hwan Tae; An, Jungsuk; Ahn, Jeong Yeal

doi:10.3343/alm.2016.36.3.266

Cited by 6 publications

(3 citation statements)

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“…Extrarenal sites of oxalate deposition include bone, bone marrow, blood vessels, skin, retina, and thyroid 5 . As seen in our case, diffuse replacement of bone marrow parenchyma by oxalate crystals may lead to cytopenias, leukoerythroblastosis, and hepatosplenomegaly 6 . Calcium oxalate crystals are birefringent under polarized microscopy and often lead to a granulomatous reaction within the bone marrow.…”

Section: Discussionsupporting

confidence: 60%

“…A review of the literature demonstrates the rarity of the identification of bone marrow oxalosis. Although several case reports of bone marrow oxalosis in the setting of primary hyperoxaluria have been described, 5,6,15,16 we were able to find only a single report describing this condition with secondary hyperoxaluria 17 . Bernhardt et al described a patient with Crohn's disease with multiple small bowel resection resulting in SBS and hyperoxaluria.…”

Section: Discussionmentioning

confidence: 87%

“…5 As seen in our case, diffuse replacement of bone marrow parenchyma by oxalate crystals may lead to cytopenias, leukoerythroblastosis, and hepatosplenomegaly. 6 Calcium oxalate crystals are birefringent under polarized microscopy and often lead to a granulomatous reaction within the bone marrow. The development of pancytopenia is a rare and late finding of this process.…”

Section: Discussionmentioning

confidence: 99%

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Bone marrow oxalosis with pancytopenia in a patient with short bowel syndrome: Report of a case and review of the literature

Bering

Wiedmeier-Nutor

Sproat

et al. 2022

J Parenter Enteral Nutr

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Systemic oxalosis is a condition in which calcium oxalate crystals deposit into various bodily tissues. Although this may occur as the result of a rare primary syndrome in which an error of glyoxylate metabolism causes an overproduction of oxalate, it is more often seen as a secondary process characterized by increased enteric oxalate absorption. Here, we describe a patient with short bowel syndrome on long-term parenteral nutrition support who developed a unique manifestation of systemic oxalosis, leading to deposition of oxalate crystals within the bone marrow contributing to pancytopenia. In this report, in addition to reviewing the literature on this presumably rare manifestation of oxalosis, we also discuss its pathogenesis in the setting of short bowel syndrome and its management, including prevention.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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