Bone Mineral Density and Bone Acquisition in Children and Young Adults with Cystic Fibrosis: A Follow-up Study

Újhelyi, Rita; Treszl, András; Vásárhelyi, Barna; Holics, K; Tóth, Miklós; Arató, András; Tulassay, Tivadar; Tulassay, Zsolt; Szathmári, Miklós

doi:10.1097/00005176-200404000-00007

Cited by 39 publications

(29 citation statements)

References 32 publications

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“…Their results suggest that reduced BMD in CF appears to have a genetic component, independent of the disease severity and nutritional deficits. This fascinating observation is in line with the results found by our group [2]. It was found that healthy mothers of CF children (who are obligate heterozygous carriers of a CFTR mutation) have lower than normal BMD values.…”

Section: To the Editorssupporting

confidence: 90%

“…Data were then re-analysed with the purpose of looking into the reproducibility of sputum neutrophilia between the two inhaled challenges, treating the effects of the single-dose salmeterol as no more than placebo [2]. Our findings showed that following the first LPS challenge, the mean total sputum cell counts increased by 31.…”

Section: To the Editorsmentioning

confidence: 89%

“…Using 1 week prior as a baseline, sputum induced at the 6th h after LPS challenge showed no significant differences in the increase of total cell counts in the two treatment periods (mean difference (95% confidence interval) salmeterol versus placebo: 10.6610 6 cells?mL (-8.33-31.92); p50.20; unpublished data). The assertion that salmeterol does not protect against airway neutrophilic inflammation was subsequently supported in a more robust study, where subjects were randomised to receiving either daily salmeterol for 3 weeks or placebo, prior to inhaled LPS challenge, in a crossover study [2].…”

Section: To the Editorsmentioning

confidence: 99%

“…Using such a human experimental model of airway neutrophilia to understand the inhaled effects of endotoxin [3], and to examine for potential anti-inflammatory properties of therapeutic agents [2] appears to be a validated approach. MICHEL et al [3] employed a model of weekly inhaled challenges of incremental LPS doses (0.5 mg, 5 mg and 50 mg) to provide evidence for dose responsiveness of LPS in airway inflammation and systemic effects in healthy human subjects.…”

Section: To the Editorsmentioning

confidence: 99%

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The prevalence of ΔF508 in primary osteoporotic patients

Treszl¹

2005

Eur Respir J

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Section: To the Editorssupporting

confidence: 90%

Section: To the Editorsmentioning

confidence: 89%

Section: To the Editorsmentioning

confidence: 99%

Section: To the Editorsmentioning

confidence: 99%

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The prevalence of ΔF508 in primary osteoporotic patients

Treszl¹

2005

Eur Respir J

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“…Se ha demostrado además una prevalencia creciente de enfermedad ósea en los adultos con FQ, caracterizada x osteopenia en el 50-75% de ellos y fracturas costales o de aplastamiento vertebral 27 , de manera que actualmente se recomienda control anual con densitometría ósea a partir de los 10 años de edad 12,28 . Otros factores no nutricionales como la susceptibilidad genética, retraso puberal o estado inflamatorio participan en su génesis multifactorial 29 . La vitamina K es cofactor de la osificación y junto al déficit de vitamina D puede tener un rol importante en la osteopenia asociada a FQ 30 .…”

Section: Déficits Nutricionalesunclassified

Manejo Nutricional en Niños y Adolescentes con Fibrosis Quística

2009

Rev. chil. pediatr.

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Nutritional Management of Children with Cystic Fibrosis: Review and Practical ApplicationsThe importance of optimal nutrition has been well demonstrated in Cystic Fibrosis patients; it affects their mortality, diminishes morbidity and could decrease the deterioration of pulmonary function. However, success of nutritional treatment depends mostly of its early onset. Assistance by enteral route as well as gastrostomy in early stages becomes important since early detection of nutritional deficits and active support result in better response to treatment and slower deterioration of pulmonary function. With an increased survival, new nutritional challenges appear, like deficits of specific EFA, micronutrients, minerals, and possible antioxidant and anti-inflammatory effects of various nutrients. The object of this article is to update nutritional treatment of children and adolescent CF patients. RESUMENLa importancia de un óptimo estado nutricional ha sido bien demostrada en los pacientes con Fibrosis Quística; incide en la mortalidad, disminuye la morbilidad y podría favorecer un menor deterioro de la función pulmonar. Sin embargo, el éxito del tratamiento nutricional depende en gran medida de la prontitud con que se realice, ya que la detección precoz del déficit nutricional favorece una mejor respuesta al tratamiento, a la vez que una actitud más activa favorece un menor deterioro, de manera que tanto el apoyo por vía enteral como la indicación de gastrostomía en etapas menos tardías cobran mayor relevancia. Con el aumento de la sobrevida se presentan además nuevos desafíos nutricionales, como son déficits específicos de AGE, micronutrientes y minerales, al igual que efectos antioxidantes y antiinflamatorios de diversos nutrientes. En esta revisión se espera haber entregado un conocimiento actualizado y aportado algunas herramientas para el manejo nutricional de los niños con FQ.

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Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review

et al. 2019

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Background Cystic fibrosis (CF) is characterized by changes in fat mass and lean body mass that may have important prognostic value. We aim to appraise the type and frequency of application of body composition (BC) methods in child and adult patients with CF. Methods We used 4 databases (Embase, PubMed, Scopus, and Web of Science) to perform the literature search. The search was conducted from January 2017 to February 2017. Two independent reviewers selected articles based on titles and abstracts to check eligibility for inclusion. All study designs or types of articles (abstract, full text) were considered. Results Eighty‐four full‐text articles and 40 studies presented only as abstracts were selected. Sixty‐four studies included children and adolescents (age range of 0.1–18 years), and 41 studies recruited adults (range of 18–57 years); 13 studies included both age groups. Dual‐energy X‐ray absorptiometry (DXA) was used in 56 studies (33.9%), and bioelectric impedance analysis (BIA) was used in 12 studies (9.7%), whereas 38 studies (30.6%) combined different methods (up to 5 different methods) to assess BC. Conclusions The results show a large variability in the application of BC methods in patients with CF that makes the comparison between studies difficult. The only methods with a sufficient body of literature are DXA and BIA.

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Bone Mineral Density and Bone Acquisition in Children and Young Adults with Cystic Fibrosis: A Follow-up Study

Cited by 39 publications

References 32 publications

The prevalence of ΔF508 in primary osteoporotic patients

The prevalence of ΔF508 in primary osteoporotic patients

Manejo Nutricional en Niños y Adolescentes con Fibrosis Quística

Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review

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