Bone mineral density, bone remodeling and osteoprotegerin in patients with acute coronary syndrome

Abstract

The objective of this study was to evaluate the relationship between coronary disease and osteoporosis and determine the effect of osteoprotegerin (OPG) on bone remodeling and bone mineral density (BMD) in a group of patients with acute coronary syndrome. Eightythree patients (52 males and 31 women) with acute coronary syndrome (75 patients with acute myocardial infarction and 8 with unstable angina) with an average age of 61 ± 10 years were studied. Levels of osteocalcin, urinarydeoxypyridinoline, OPG and the receptor activator of nuclear factor-κB ligand (RANKL) were determined during the hospital stay. Femoral neck, trochanter and lumbar spine densitometry was carried out using a DXA densitometer. Thirty percent of patients presented osteoporosis (39% of females and 26% of males). Osteoporotic patients were older and had a lower weight and height and elevated serum levels of osteocalcin (3.6 ± 2.25 2.63 versus ± 1.55, p = 0.05). Levels of OPG and RANKL were similar in both groups and showed no relationship with BMD. In conclusion, no relationship was observed between the OPG/RANKL system and BMD in these patients.

Osteoprotegerin and B-type natriuretic peptide in acute coronary syndromes with preserved systolic function: Relation to coronary artery disease extension

“…Moreover, OPG increased proportionally with the number diseased vessels and the amount of myocardium at risk (as indicated by the Duke Jeopardy score). These data appear consistent with Schoppet et al obtained in patients with SA [11], but opposite to those of Perez-Castrillon probably because of high percentage of osteoporosis in the study [13].…”

Effect of Beta-Blockers on Bone Mineral Density and Osteoporotic Fractures

“…женщины, имеющие множественные переломы перед вступлением в исследование, имели в 5 раз больший риск ссз-ас [2]. в ряде клинических исследований была продемонстрирована ассоциация низкой мпк с инфарктом миокарда, острым коронарным синдромом и сердечной недостаточностью II и III функционального класса [3,4,5]. высказывалось мнение, что низкая мпк является независимым фактором риска атеросклероза коронарных артерий [6].…”

A complication in male patients awaiting heart transplantation: Osteoporosis

“…Pérez-Castrillon et al found no relationship between bone turnover markers [osteoprotogerin (OPG)/ receptor activator of nuclear factor-KB ligand (RANKL)] and BMD in patients with acute coronary syndrome [12]. In addition elevated serum levels of osteocalcin, a marker of bone turnover, presented by their coronary patients with osteoporosis [12].…”