Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls

Gilboe, Inge‐Margrethe; Kvien, Tore K; Haugeberg, Glenn; Husby, Gunnar

doi:10.1136/ard.59.2.110

Cited by 115 publications

(120 citation statements)

References 33 publications

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“…2055 (4)(5)(6)10,38). Two previous studies of childhood-onset SLE (12,13) also found lower BMD in the spine and femoral neck of patients compared with controls.…”

Section: Osteopenia In Patients With Childhood-onset Slementioning

confidence: 84%

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Lilleby¹,

Lien²,

Frøslie³

et al. 2005

Arthritis & Rheumatism

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Objective. To determine the frequency of osteopenia in patients with childhood-onset systemic lupus erythematosus (SLE) compared with that in healthy matched controls, and to evaluate the relationship between disease-related variables and bone mineral mass.Methods. Bone mineral density (BMD) and bone mineral content (BMC) were measured in a cohort of 70 patients with childhood-onset SLE (mean ؎ SD disease duration 10.8 ؎ 8.3 years, mean ؎ SD age 26.4 ؎ 9.9 years) and 70 age-and sex-matched healthy controls. BMD and BMC of the femoral neck, lumbar spine, total body, and distal one-third of the radius were measured by dual x-ray absorptiometry. We investigated the relationship between BMC and the following disease variables: cumulative dose of corticosteroids, organ damage, current use of corticosteroids, use of cyclophosphamide, age at disease onset, and disease activity at the time of diagnosis. Biochemical markers of bone metabolism were also measured.Results. BMD values for the lumbar spine and femoral neck were significantly lower in patients than in healthy controls. The reduction in BMD of the lumbar spine was significantly greater than that of the total body. In multiple linear regression analyses, a higher cumulative corticosteroid dose was significantly associated with lower BMC of the lumbar spine and femoral neck. Decreased lumbar spine BMC was also related to male sex.Conclusion. The frequency of osteopenia was higher in patients with childhood-onset SLE than in matched controls. The lumbar spine was the most seriously affected skeletal site, followed by the femoral neck. The cumulative dose of corticosteroids was shown to be an important explanatory variable for BMC values in the lumbar spine and femoral neck.

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“…2055 (4)(5)(6)10,38). Two previous studies of childhood-onset SLE (12,13) also found lower BMD in the spine and femoral neck of patients compared with controls.…”

Section: Osteopenia In Patients With Childhood-onset Slementioning

confidence: 84%

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Lilleby¹,

Lien²,

Frøslie³

et al. 2005

Arthritis & Rheumatism

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“…HRQoL is an important complement to measures of disease activity and damage (11)(12)(13). For instance, comparative studies have shown that patients with SLE 5 perceive reduced HRQoL compared with controls and in parity with several other diseases (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of life

Pettersson

Lövgren

Eriksson

et al. 2012

Scandinavian Journal of Rheumatology

102

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PostprintThis is the accepted version of a paper published in Scandinavian Journal of Rheumatology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Citation for the original published paper (version of record):Pettersson, S., Lövgren, M., Eriksson, L., Moberg, C., Svenungsson, E. et al. (2012) An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of life. Online is checked for eligibility for copyright before being made available in the live archive. URLs from City Research Online may be freely distributed and linked to from other web pages. Scandinavian Journal of Rheumatology Versions of researchThe version in City Research Online may differ from the final published version. Users are advised to check the Permanent City Research Online URL above for the status of the paper. EnquiriesIf you have any enquiries about any aspect of City Research Online, or if you wish to make contact with the author(s) of this paper, please email the team at publications@city.ac.uk.

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“…Økt forekomst av osteoporose er også påvist hos pasienter med andre inflammatoriske sykdommer som f.eks. SLE og ankyloserende spondylitt (33)(34)(35).…”

Section: Prevalens Av Osteoporoseunclassified

Osteoporose

Haugeberg¹

2009

Nor J Epidemiol

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Osteoporosis and its clinical consequences the fractures are among the main contributors of increased morbidity and increased mortality among elderly people. After the age of 50 years every second female and 1 out of 5 males during the rest of their life time will have a low energy fracture. Patients with several inflammatory rheumatic joint diseases and endocrinological diseases have been shown to have an increased risk for osteoporosis and low energy fracture. The burden of the osteoporosis bone disease for both individuals (morbidity and mortality) and society (costs) is high.<script type="text/javascript"></script> <blockquote><blockquote><blockquote><p align="left"> </p></blockquote></blockquote></blockquote>

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Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls

Cited by 115 publications

References 33 publications

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

Frequency of osteopenia in children and young adults with childhood‐onset systemic lupus erythematosus

An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of life

Osteoporose

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