Bone Mineral Measurement of Phalanges: Comparison of Radiographic Absorptiometry and Area Dual X-ray Absorptiometry

Gulam, M; Thornton, Mike M.; Hodsman, Anthony B.; Holdsworth, David W.

doi:10.1148/radiology.216.2.r00au10586

Cited by 26 publications

(27 citation statements)

References 36 publications

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“…Scans were analysed as described previously [40]. Briefly, a calibrating phantom composed of air, water and cortical bonemimicking epoxy (SB3; Gammex, Middleton WI, USA) [41] was scanned together with the animals. On the eXplore Locus Ultra, 1,000 projection images were obtained over a single 16- .…”

Section: Micro-computed Tomography (Micro-ct)mentioning

confidence: 99%

Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice

Beaucage

Xiao

Pollmann

et al. 2013

Purinergic Signalling

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The P2X7 receptor is an ATP-gated cation channel expressed by a number of cell types. We have shown previously that disruption of P2X7 receptor function results in downregulation of osteogenic markers and upregulation of adipogenic markers in calvarial cell cultures. In the present study, we assessed whether loss of P2X7 receptor function results in changes to adipocyte distribution and lipid accumulation in vivo. Male P2X7 loss-of-function (KO) mice exhibited significantly greater body weight and epididymal fat pad mass than wild-type (WT) mice at 9 months of age. Fat pad adipocytes did not differ in size, consistent with adipocyte hyperplasia rather than hypertrophy. Histological examination revealed ectopic lipid accumulation in the form of adipocytes and/or lipid droplets in several non-adipose tissues of older male KO mice (9-12 months of age). Ectopic lipid was observed in kidney, extraorbital lacrimal gland and pancreas, but not in liver, heart or skeletal muscle. Specifically, lacrimal gland and pancreas from 12-month-old male KO mice had greater numbers of adipocytes in perivascular, periductal and acinar regions. As well, lipid droplets accumulated in the renal tubular epithelium and lacrimal acinar cells. Blood plasma analyses revealed diminished total cholesterol levels in 9-and 12-month-old male KO mice compared with WT controls. Interestingly, no differences were observed in female mice. Moreover, there were no significant differences in food consumption between male KO and WT mice. Taken together, these data establish novel in vivo roles for the P2X7 receptor in regulating adipogenesis and lipid metabolism in an age-and sex-dependent manner.

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Section: Micro-computed Tomography (Micro-ct)mentioning

confidence: 99%

Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice

Beaucage

Xiao

Pollmann

et al. 2013

Purinergic Signalling

Self Cite

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“…[16] This can account for the differences between this study and that of Shiarishi et al [17] This loss of calcium is, nevertheless, important, as hypercalciuria is one of the most common features of postmenopausal bone loss with osteoporosis in 50% of patients. [18,19] As the name refers, bone mineral density is a measure of the mineral content of a bone or specific region of a bone and, therefore, it indicates a measure of strength of a bone. In the present study, the diameters of the tibial head and shaft were significantly reduced in the unsupplemented Ovx group.…”

Section: Discussionmentioning

confidence: 99%

“…Similar findings have been also reported in the literature. [9,[19][20][21] A reduction in the bone mineral density has been reported for the greater trochanter, shaft, and distal epiphysis of the femur in the Ovx rats, compared to the Shm group. [16] In addition, Giavaresi et al [22] reported that, in rats treated with alendronate sodium following ovariectomy, there was a 15% increase in the bone density in the femoral epiphysis, compared to the control group, and a 27% increase, compared to the Ovx unsupplemented group.…”

Section: Discussionmentioning

confidence: 99%

The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Ozsahin

Çam

Dere

et al. 2017

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Materials and methods:Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days.Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less wellformed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05). Conclusion:Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.

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“…The accuracy of this technique in its original form was about 6%, with an in-vivo, inter-radiograph precision error of about 2% (Colbert and Bachtell 1981). The application of dualenergy principles, special film and automatic or semi-automatic computer analysis improved the accuracy of the technique to 4.1% (Gulam et al 2000). No comparative data for current in-vivo, inter-radiograph precision were found.…”

Section: Radiographic Absorptiometrymentioning

confidence: 99%

Feasibility of radiographic absorptiometry of the mandible as an osteoporosis screening method

Skipper

2003

Med. Phys.

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Bone Mineral Measurement of Phalanges: Comparison of Radiographic Absorptiometry and Area Dual X-ray Absorptiometry

Cited by 26 publications

References 36 publications

Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice

Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice

The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Feasibility of radiographic absorptiometry of the mandible as an osteoporosis screening method

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