Bone pain caused by isolated paraspinal extramedullary relapse of childhood acute lymphoblastic leukemia

Alessandri, Angela J.; Pritchard, Sheila; Massing, Bonnie G.; Sargent, Michael A.; Theissen, Paul; Schultz, Kirk R.

doi:10.1002/(sici)1096-911x(199908)33:2<113::aid-mpo10>3.0.co;2-k

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Chimeric antigen receptor T‐cell therapy for marrow and extramedullary relapse of infant acute lymphoblastic leukemia

Moskop

Pommert

Thakrar

et al. 2020

Pediatric Blood & Cancer

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Chimeric antigen receptor (CAR) T-cells, engineered autologous T-cells that target antigens found in leukemia, have shown durable remissions in relapsed acute lymphoblastic leukemia (ALL). Infant ALL with KMT2A rearrangements (KMT2Ar) is a rare, aggressive form of leukemia associated with extramedullary disease both at diagnosis and at relapse, and overall outcomes for these patients are dismal. Here we report the successful use of tisagenlecleucel, a CAR T-cell product approved for relapsed/refractory ALL, in a patient with KMT2Ar infant ALL who was treated for combined marrow and extramedullary (renal) relapse.

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Chimeric antigen receptor T‐cell therapy for marrow and extramedullary relapse of infant acute lymphoblastic leukemia

Moskop

Pommert

Thakrar

et al. 2020

Pediatric Blood & Cancer

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Bone relapse in acute lymphoblastic leukemia

et al. 2004

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Acute lymphoblastic leukemia (ALL) can occasionally relapse in unusual extramedullary sites like bone. Here we present a 6.5-year old boy with 'T' cell ALL who developed a swelling in left tibia which was infiltrated with lymphoblasts 7 months after completion of chemotherapy. Bone marrow and cerebrospinal fluid were negative for blasts. This is the first reported case of bone relapse in ALL from India. We discuss the previous cases of isolated bone relapse in ALL reported in English literature.

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