Bone Physiology and Biology

Gasser, Jürg A.; Kneissel, Michaela

doi:10.1007/978-3-319-56192-9_2

Cited by 30 publications

(19 citation statements)

References 239 publications

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“…The vascular structures in Haversian canals show typical capillary properties and are often paired. In general, they are fenestrated, lined with partial layer of endothelial cells and bounded by a continual thick basal membrane that restricts the transport of ions across the capillary [ 44 ]. It is known that Haversian system is the classic result of the process of bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Omelka

Blahová

Kováčová

et al. 2020

Animals

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Cornelian cherry (Cornus mas L.) is a medicinal plant with a range of biological features. It is often used as a nutritional supplement in the treatment of diabetes mellitus. Our study was aimed to first investigate the effects of Cornelian cherry pulp on bone quality parameters in Zucker diabetic fatty (ZDF) rats. Moreover, lipid-lowering properties of this fruit were also evaluated. Adult rats (n = 28) were assigned into four groups of seven individuals each: L group (non-diabetic lean rats), C group (diabetic obese rats), and E1 and E2 groups (diabetic obese rats receiving 500 and 1000 mg/kg body weight of Cornelian cherry pulp, respectively, for 10 weeks). Significantly lower levels of triglyceride, total cholesterol and alkaline phosphatase activity were determined in the E2 group versus the C group. A higher dose of Cornus mas also had a beneficial impact on femoral weight, cortical bone thickness, relative volume of trabecular bone and trabecular thickness. We observed elevated density of Haversian systems and accelerated periosteal bone apposition in both treated groups (E1 and E2). Our results clearly demonstrate that Cornelian cherry pulp has a favorable effect on lipid disorder and impaired bone quality consistent with type 2 diabetes mellitus in a suitable animal model.

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Section: Discussionmentioning

confidence: 99%

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Omelka

Blahová

Kováčová

et al. 2020

Animals

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“…hMSCs seeded in fibrin:polyurethane scaffolds were treated with either chondrogenic culture media supplemented with TGFβ1 [31] or osteogenic differentiation media with or without bone morphogenic protein 2 (BMP2) [32]. Additionally, low and high oxygen conditions were compared.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro

Monaco

Ladner

Haj

et al. 2021

Cells

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In the field of tissue engineering, progress has been made towards the development of new treatments for cartilage and bone defects. However, in vitro culture conditions for human bone marrow mesenchymal stromal cells (hBMSCs) have not yet been fully defined. To improve our understanding of cartilage and bone in vitro differentiation, we investigated the effect of culture conditions on hBMSC differentiation. We hypothesized that the use of two different culture media including specific growth factors, TGFβ1 or BMP2, as well as low (2% O2) or high (20% O2) oxygen tension, would improve the chondrogenic and osteogenic potential, respectively. Chondrogenic and osteogenic differentiation of hBMSCs isolated from multiple donors and expanded under the same conditions were directly compared. Chondrogenic groups showed a notable upregulation of chondrogenic markers compared with osteogenic groups. Greater sGAG production and deposition, and collagen type II and I accumulation occurred for chondrogenic groups. Chondrogenesis at 2% O2 significantly reduced ALP gene expression and reduced type I collagen deposition, producing a more stable and less hypertrophic chondrogenic phenotype. An O2 tension of 2% did not inhibit osteogenic differentiation at the protein level but reduced ALP and OC gene expression. An upregulation of ALP and OC occurred during osteogenesis in BMP2 containing media under 20% O2; BMP2 free osteogenic media downregulated ALP and also led to higher sGAG release. A higher mineralization was observed in the presence of BMP2 during osteogenesis. This study demonstrates how the modulation of O2 tension, combined with tissue-specific growth factors and media composition can be tailored in vitro to promote chondral or endochondral differentiation while using the same donor cell population.

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“…El hueso es una forma especial de tejido conectivo fisiológicamente mineralizado, que se renueva constantemente en respuesta a hormonas, fuerzas mecánicas y envejecimiento; está formado por células vivas y muertas incrustadas en la matriz orgánica mineralizada, compuesta de colágeno tipo I, proteoglicanos y proteínas no colagenosas. 1,2 La remodelación ósea permite que el tejido óseo responda a la reparación mecánica de carga y evite microdaños, mantiene el control de la calidad ósea y permite la liberación de factores de crecimiento y minerales almacenados durante toda la vida. 2 En la infancia la remodelación ósea es crítica para la erupción dental y durante la dentición permanente, la erupción requiere de reabsorción de las raíces de la dentición decidua y del hueso coronal al órgano dentario en desarrollo.…”

Section: Introductionunclassified

Bifosfonatos en Odontopediatría: revisión de la literatura, protocolo de manejo y reporte de un caso clínico

Madrigal

Fernández

Rodríguez

2021

Rev. Odontopediatr. Latinoam.

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En la actualidad, los bifosfonatos son utilizados en la población pediátrica con diagnóstico de osteogénesis imperfecta, desórdenes neuromusculares, displasia ósea, displasia fibrosa, osteoporosis idiopática juvenil, enfermedad de Crohn y trastornos reumatológicos. La osteonecrosis de los maxilares secundaria al tratamiento con bifosfonatos, se ha convertido en una complicación cada vez más común debido al incremento de su uso en la población adulta. En cuanto a la atención pediátrica la información es escasa. Este estudio presenta el caso clínico de una paciente de sexo femenino con diagnóstico de osteogénesis imperfecta tipo III quien fue tratada con múltiples extracciones dentales bajo anestesia general, previa administración de amoxicilina 50 mg/kg 1 hora antes; debido a erupción anómala de caninos y primeros premolares superiores, así como persistencia de caninos y molares temporales superiores. Se realizaron citas control postoperatorias, en donde mostró adecuado proceso de cicatrización sin datos de necrosis maxilar. El objetivo es informar al estomatólogo sobre cómo actúan los bifosfonatos, los diagnósticos en la población pediátrica tratados con dicho fármaco y dar a conocer el protocolo de manejo de estos pacientes. Se realizó una revisión integradora en las bases de datos PubMed y Cochrane Library, los artículos fueron seleccionados de acuerdo a los criterios establecidos.

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Bone Physiology and Biology

Cited by 30 publications

References 239 publications

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro

Bifosfonatos en Odontopediatría: revisión de la literatura, protocolo de manejo y reporte de un caso clínico

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