Bone regeneration: Biomaterials as local delivery systems with improved osteoinductive properties

Martín, Víctor; Bettencourt, Ana

doi:10.1016/j.msec.2017.04.038

Cited by 133 publications

(96 citation statements)

References 59 publications

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“…Biologically inspired biomaterials have been developed based on the functionalization of implant surfaces and bioengineered scaffolds with ECM‐derived biomolecules. Different types of osteoconductive biomaterials, such as hydroxyapatite (HA), calcium phosphates (CaPs), and bioactive glasses (BGs) have been shown to enable the nucleation and growth of CaP crystals both in vitro and in vivo (Martin & Bettencourt, ). Among these, BGs possess comparatively higher bioactivity than HA and CaPs, owing to their high surface reactivity and their ionic dissolution products in aqueous environments (Ciraldo, Boccardi, Melli, Westhauser, & Boccaccini, ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Moghanian

Portillo-Lara

Sani

et al. 2019

J Tissue Eng Regen Med

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Orthopedic surgical procedures based on the use of conventional biological graft tissues are often associated with serious post-operative complications such as immune rejection, bacterial infection, and poor osseointegration. Bioresorbable bone graft substitutes have emerged as attractive alternatives to conventional strategies because they can mimic the composition and mechanical properties of the native bone. Among these, bioactive glasses (BGs) hold great potential to be used as biomaterials for bone tissue engineering owing to their biomimetic composition and high biocompatibility and osteoinductivity. Here, we report the development of a novel composite biomaterial for bone tissue engineering based on the incorporation of a modified strontium-and lithium-doped 58S BG (i.e., BG-5/5) into gelatin methacryloyl (GelMA) hydrogels. We characterized the physicochemical properties of the BG formulation via different analytical techniques. Composite hydrogels were then prepared by directly adding BG-5/5 to the GelMA hydrogel precursor, followed by photocrosslinking of the polymeric network via visible light. We characterized the physical, mechanical, and adhesive properties of GelMA/BG-5/5 composites, as well as their in vitro cytocompatibility and osteoinductivity. In addition, we evaluated the antimicrobial properties of these composites in vitro, using a strain of methicillinresistant Staphylococcus Aureus. GelMA/BG-5/5 composites combined the functional characteristics of the inorganic BG component, with the biocompatibility, biodegradability, and biomimetic composition of the hydrogel network. This novel biomaterial could be used for developing osteoinductive scaffolds or implant surface coatings with intrinsic antimicrobial properties and higher therapeutic efficacy. KEYWORDSantimicrobial, bioactive glass, bioadhesive, bone tissue engineering, orthopedic biomaterials, osteoinductive *These authors contributed equally to this work.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Moghanian

Portillo-Lara

Sani

et al. 2019

J Tissue Eng Regen Med

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“…Autografting is the gold standard currently used to treat bone defects. However, this treatment has many limitations, including limited bone mass, donor site complications, and bone resorption . Allografting is another primary treatment option but is limited by infection and immune rejection .…”

Section: Introductionmentioning

confidence: 99%

Bisphosphonate‐Functionalized Scaffolds for Enhanced Bone Regeneration

Cui

Zhu

et al. 2019

Adv Healthcare Materials

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Bone defect healing is an intricate but methodical process that restores bone integrity and represents an intrinsic capacity of The local sustained release of bioactive substances are attracting increasing attention in bone tissue engineering, which is beneficial to bone tissue formation and helps to improve the bone ingrowth ability of a scaffold. Bisphosphonates (BPs), as a representative kind of osteoclast inhibitors, are proven to possess excellent osteogenic induction capability. Accordingly, various physical and chemical strategies are developed to functionalize bone tissue scaffolds with BPs to achieve controlled release profiles. Compared with traditional treatment modalities, local release of BPs from these composite scaffolds will contribute to continuous bone integration without the risk of many complications. This review explores the molecular mechanisms of BPs on bone metabolism and analyzes the appropriate concentrations of BPs that promote bone regeneration. The advanced BP loading strategies, implant modification technologies, and BP-loaded composite scaffolds based on different matrices are summarized. Finally, the latest advances and the future development of BP-modified scaffolds for enhanced bone regeneration are discussed. This article provides leading-edge design strategies of the BP-functionalized bone engineering scaffolds for improved bone repairability.

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“…More than 2.2. million bone grafting procedures are performed annually worldwide to repair bone defects in orthopaedics, neurosurgery and dentistry (Giannoudis et al ., ; Ginebra et al ., ). This is even more important due to the expected ageing society and the increase in activity up to older age, meaning that the number of patients undergoing these procedures will raise, as well as the associated costs in treating those patients (Martin & Bettencourt, ; Winkler et al ., ). Despite the profound clinical and economic impact, treatments of bone defects remain controversial, especially when the defect is critical sized (Schemitsch, ; Nauth et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

Fernández

Witte²,

Tozzi

2019

Journal of Microscopy

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Bone as such displays an intrinsic regenerative potential following fracture; however, this capacity is limited with large bone defects that cannot heal spontaneously. The management of critical‐sized bone defects remains a major clinical and socioeconomic need with osteoregenerative biomaterials constantly under development aiming at promoting and enhancing bone healing. X‐ray computed tomography (XCT) has become a standard and essential tool for quantifying structure–function relationships in bone and biomaterials, facilitating the development of novel bone tissue engineering strategies. This paper presents recent advancements in XCT analysis of biomaterial‐mediated bone regeneration. As a noninvasive and nondestructive technique, XCT allows for qualitative and quantitative evaluation of three‐dimensional (3D) scaffolds and biomaterial microarchitecture, bone growth into the scaffold as well as the 3D characterisation of biomaterial degradation and bone regeneration in vitro and in vivo. Furthermore, in combination with in situ mechanical testing and digital volume correlation (DVC), XCT demonstrated its potential to better understand the bone–biomaterial interactions and local mechanics of bone regeneration during the healing process in relation to the regeneration achieved in vivo, which will likely provide valuable knowledge for the development and optimisation of novel osteoregenerative biomaterials. Lay Description Bone, being a dynamically adaptable material, displays excellent regenerative properties following fracture. However, the self‐healing capacity of bone becomes more difficult with large bone defects. Those defects are common and occur in many clinical situations; hence, biomaterials are mostly used to restore both bone structure and function in the defect site. X‐ray computed tomography (XCT) is a powerful tool to evaluate bone regeneration in critical‐sized defects after the implantation of biomaterials, allowing to an improved understanding of the regeneration process following different bone tissue engineering approaches. This paper focuses on recent advancements in XCT analysis to characterise biomaterial‐mediated bone regeneration in critical‐sized defects. XCT supports three‐dimensional (3D) analysis of biomaterials, scaffolds and regenerated bone microarchitecture, as well as bone ingrowth into the scaffold. As a nondestructive technique, XCT allows for a 3D characterisation of biomaterial degradation and bone regeneration over time. In addition, XCT combined with in situ mechanical experiments and digital volume correlation (DVC) provides a 3D evaluation and quantification of bone–biomaterial interactions and deformation mechanisms during the regeneration process. This remains essential for the development and enhancement of novel biomaterials able to produce bone that is comparable with the native tissue they aim to replace.

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Bone regeneration: Biomaterials as local delivery systems with improved osteoinductive properties

Cited by 133 publications

References 59 publications

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Synthesis and characterization of osteoinductive visible light‐activated adhesive composites with antimicrobial properties

Bisphosphonate‐Functionalized Scaffolds for Enhanced Bone Regeneration

Applications of X‐ray computed tomography for the evaluation of biomaterial‐mediated bone regeneration in critical‐sized defects

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