2005
DOI: 10.1038/sj.gt.3302439
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Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4)

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Cited by 187 publications
(131 citation statements)
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“…A variety of systems have been developed to encapsulate both recombinant growth factors and plasmid DNA encoding these factors in biodegradable polymer platforms useful for tissue engineering, 59,60 and these systems can be designed to enable combinations or sequences of factors to be delivered with well controlled kinetics, 61,62 which more closely mimics the normal developmental and regenerative processes than delivery of single factors. The utility of this approach has recently been demonstrated in the context of bone and muscle regeneration, 54,61,63 and in the formation of new blood vessel networks that can alleviate tissue ischemia and enhance the regenerative potential of cell transplantation strategies. 64 …”
Section: Cell Instructive Polymers Adhesion Ligand Presentationmentioning
confidence: 99%
“…A variety of systems have been developed to encapsulate both recombinant growth factors and plasmid DNA encoding these factors in biodegradable polymer platforms useful for tissue engineering, 59,60 and these systems can be designed to enable combinations or sequences of factors to be delivered with well controlled kinetics, 61,62 which more closely mimics the normal developmental and regenerative processes than delivery of single factors. The utility of this approach has recently been demonstrated in the context of bone and muscle regeneration, 54,61,63 and in the formation of new blood vessel networks that can alleviate tissue ischemia and enhance the regenerative potential of cell transplantation strategies. 64 …”
Section: Cell Instructive Polymers Adhesion Ligand Presentationmentioning
confidence: 99%
“…In one study, PEI25 was beneficial when pDNA was delivered in scaffolds in a cranial defect site. (59) Other studies with sustained release formulations (63) or a carrier functional in vitro (N,N,N-trimethyl chitosan (100) ) did not result in improved bone formation in a similar intracranial site. It remains to be seen whether the scaffold effects (chemical composition, physical architecture controlling cell invasion, degradation products, etc.)…”
Section: Pharmacokinetics and Pharmacodynamics Of Gene Deliverymentioning
confidence: 92%
“…(58) The broadly effective carrier 25 kDa polyethylenimine (PEI25) has been employed to deliver BMP-4 plasmid (200 µg) in a poly (lactic-co-glycolic) acid implant for regeneration of a rat criticalsize skull defect. (59) Bone formation was observed around defect (33) and healing of spinal arthrodesis model in athymic nude mice (168) TGFb Orthotopic AV Increased epiphyseal thickness was observed after injection of viral particles into the humerus of rats (169) …”
Section: Delivery With Synthetic Carriersmentioning
confidence: 99%
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