Bone regenerative medicine: classic options, novel strategies, and future directions

Oryan, Ahmad; Alidadi, Soodeh; Moshiri, Ali; Maffulli, Nicola

doi:10.1186/1749-799x-9-18

Cited by 934 publications

(933 citation statements)

References 146 publications

(315 reference statements)

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“…Autograft, surgically obtained from the patient, has persisted as the gold standard of treatment but has also been associated with a multitude of complications at the donor site, limited availability, and variation in ultimate outcomes (eg, eventual nonunion in some cases) [25,45]. Use of different harvest sites or combined use of cortical grafts with limited amounts of cancellous bone may not be sufficient to overcome these challenges and thus motivates continued investigation of alternative treatment strategies [17,19,32,45].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft

Krishnan

Priddy

Esancy

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Autologous bone grafting remains the gold standard in the treatment of large bone defects but is limited by tissue availability and donor site morbidity. Recombinant human bone morphogenetic protein-2 (rhBMP-2), delivered with a collagen sponge, is clinically used to treat large bone defects and complications such as delayed healing or nonunion. For the same dose of rhBMP-2, we have shown that a hybrid nanofiber mesh-alginate (NMA-rhBMP-2) delivery system provides longer-term release and increases functional bone regeneration in critically sized rat femoral bone defects compared with a collagen sponge. However, no comparisons of healing efficiencies have been made thus far between this hybrid delivery system and the gold standard of using autograft. Questions/purposes We compared the efficacy of the NMA-rhBMP-2 hybrid delivery system to morselized autograft and hypothesized that the functional regeneration of large bone defects observed with sustained BMP delivery would be at least comparable to autograft treatment as measured by total bone volume and ex vivo mechanical properties. Methods Bilateral critically sized femoral bone defects in rats were treated with either live autograft or with the NMA-rhBMP-2 hybrid delivery system such that each animal received one treatment per leg. Healing was monitored by radiography and histology at 2, 4, 8, and 12 weeks. Defects were evaluated for bone formation by longitudinal micro-CT scans over 12 weeks (n = 14 per group). The bone volume, bone density, and the total new bone formed beyond 2 weeks within the defect were calculated from micro-CT reconstructions and values compared for the 2-, 4-, 8-, and 12-week scans within and across the two treatment groups. Two animals were used for bone labeling with subcutaneously injected dyes at 4, 8, and 12 weeks followed by histology at 12 weeks to

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Section: Introductionmentioning

confidence: 99%

Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft

Krishnan

Priddy

Esancy

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Osteoinduction, is the ability of primitive, undifferentiated and pluripotent cells from the surrounding host tissue to develop osteoprogenitor cells followed by the production of osteoblasts [50,51,53]. Osteogenesis is the capacity to produce new bone by osteoblasts present within the bone graft [50,53].…”

Section: Ideal Bone Graftmentioning

confidence: 99%

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Neto¹,

Ferreira²

2018

Preprint

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Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of a bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and then is focused on the potential strategies for bone repair and regeneration. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlight that natural materials, namely the marine skeletons represent a promising alternative.

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“…Since the availability of autologous material is limited, synthetic materials offer a promising solution for bone replacement applications [1]. In this respect, bioactive glasses exhibit excellent properties: They are cytocompatible, bind quickly to bone and can stimulate bone regeneration [2].…”

Section: Introductionmentioning

confidence: 99%

Structuring of bioactive glass surfaces at the micrometer scale by direct casting intended to influence cell response

Pföss¹,

Bührig–Polaczek²,

Fischer³

et al. 2016

Biomedical Glasses

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Defect-free bioactive glass surfaces with a grooved microstructure at the low micrometer scale were achieved by a mold casting process. The process was applied to the well-known glass compositions 45S5 and 13-93. Such microstructured surfaces may exhibit especially favorable conditions for bone cell orientation and growth. The aim of the study was to assess the parameter range for a successful casting process and thus to produce samples suitable to investigate the interaction between structured surfaces and relevant cells. Viscous flow in its temperature dependence and thermal analysis were analyzed to identify a suitable process window and to design a manageable time-temperature process scheme. Counteracting effects such as formation of chill ripples, mold sticking and build-up of permanent thermal stress in the glass had to be overcome. A platinum gold alloy was chosen as mold material with the mold surface bearing the mother shape of the microstructure to be imprinted on the glass surface. First experiments studying the behavior of osteoblast-like cells, seeded on these microstructured glass surfaces revealed excellent viability and an orientation of the cells along the microgrooves. The presented results show that direct casting is a suitable process to produce defined microstructures on bioactive glass surfaces.

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Bone regenerative medicine: classic options, novel strategies, and future directions

Cited by 934 publications

References 146 publications

Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft

Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Structuring of bioactive glass surfaces at the micrometer scale by direct casting intended to influence cell response

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