Bone Resorption Markers and Dual‐EnergyX‐Ray Absorptiometry in Dogs with Avascular Necrosis, Degenerative Joint Disease, and Trauma of the Coxofemoral Joint

Abstract

Serum NTx levels vary with dog size but seem to correlate better with BMD better than urine NTx excretion in dogs with nonneoplastic bone resorption.

Preliminary investigation of urine N‐telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids

“…, Youkhanna et al . ). It was determined that a sample size of 24 dogs per group (control versus glucocorticoid) was required to confidently reject the null hypothesis that the population means are equal with a power of 0·9 and alpha set at 0·05.…”

Comparative investigation of bone mineral density using CT and DEXA in a canine femoral model

“…Measuring bone density with computed tomography instead of using dual-energy X-ray absorptiometry (DEXA) has become a focus of interest in the last few years in human and veterinary medicine. [1][2][3][4][5][6][7][8][9][10][11][12][13] However, according to the World Health Organization, the gold standard for quantitative measurements of bone density is dual-energy X-ray absorptiometry (DEXA). 14,15 Both modalities (DEXA and CT) are based on X-radiation.…”

“…[18][19][20] Although there are studies measuring bone density in dogs using DEXA, 21,22 lack of its availability and trained personnel remain huge challenges for its applicability in veterinary medicine. Therefore, several veterinary studies have focused on the use of CT for assessing bone density in a wide variety of canine bones such as vertebrae, 3,4,23-26 femoral head, 6,27,28 radius and ulna, 29,30 knee, 31 mandibula and maxilla, 32 and tarsus. 7 Although the obtained CT image also depends on the absorption of Xradiation, in contrast to DEXA a 3D replication of the scanned object is produced using a standardized linear attenuation coefficient scale, where air is defined as À1,000 and water as 0, expressed in HU.…”