2022
DOI: 10.1038/s41526-022-00195-7
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Bone strength and composition in spacefaring rodents: systematic review and meta-analysis

Abstract: Studying the effects of space travel on bone of experimental animals provides unique advantages, including the ability to perform post-mortem analysis and mechanical testing. To synthesize the available data to assess how much and how consistently bone strength and composition parameters are affected by spaceflight, we systematically identified studies reporting bone health in spacefaring animals from Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. Previously, we reported the effect of spa… Show more

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Cited by 3 publications
(3 citation statements)
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“…Thus, recent studies have investigated mice fibulae and how mechanical loading alters their biomechanical properties after hormonal changes during lactation [ 26 ] or fracture [ 27 , 28 ]. On the contrary to previous evidence on the tibia [ 5 ], our unloading protocol shows changes in both and Crystallinity – a decrease in bone matrix plasticity with more mature crystals following previous literature [ 6 , 12 , 29 ]. However, our results indicate an increase in Crystallinity with lower which could indicate that parameters other than the mineral could have impacted the decrease of plasticity.…”
Section: Discussioncontrasting
confidence: 60%
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“…Thus, recent studies have investigated mice fibulae and how mechanical loading alters their biomechanical properties after hormonal changes during lactation [ 26 ] or fracture [ 27 , 28 ]. On the contrary to previous evidence on the tibia [ 5 ], our unloading protocol shows changes in both and Crystallinity – a decrease in bone matrix plasticity with more mature crystals following previous literature [ 6 , 12 , 29 ]. However, our results indicate an increase in Crystallinity with lower which could indicate that parameters other than the mineral could have impacted the decrease of plasticity.…”
Section: Discussioncontrasting
confidence: 60%
“…Thus, the cortical bone matrix has more time to mature and shows (i) an increase in mineral size [ 23 ], (ii) an increase in bone collagen crosslinking (both enzymatic and non-enzymatic) [ 17 ], and (iii) a decrease in water content [ 24 ] inducing both an increase in brittleness and a decrease in the plasticity of the whole bone. Recent evidence [ 5 ] depicted that in rodents subjected to spaceflight, there were significant decreases in whole bone mechanical indices, including a -15.24% difference in maximum load compared to ground control animals. Additionally, bone mineral density and calcium content were significantly reduced by -3.13% and -1.75% respectively.…”
Section: Discussionmentioning
confidence: 99%
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