Bone substitution materials on the basis of BONITmatrix® up-regulate mRNA expression of IGF1 and Col1a1

The aim of this study was to examine the osteogenic potential of new flax covering materials. Bone defects were created on the skull of forty rats. Materials of pure PLA and PCL and their composites with flax fibers, genetically modified producing PHB (PLA-transgen, PCL-transgen) and unmodified (PLA-wt, PCL-wt), were inserted. The skulls were harvested after four weeks and subjected to histological examination. The percentage of bone regeneration by using PLA was less pronounced than after usage of pure PCL in comparison with controls. After treatment with PCL-transgen, a large amount of new formed bone could be found. In contrast, PCL-wt decreased significantly the bone regeneration, compared to the other tested groups. The bone covers made of pure PLA had substantially less influence on bone regeneration and the bone healing proceeded with a lot of connective tissue, whereas PLA-transgen and PLA-wt showed nearly comparable amount of new formed bone. Regarding the histological data, the hypothesis could be proposed that PCL and its composites have contributed to a higher quantity of the regenerated bone, compared to PLA. The histological studies showed comparable bone regeneration processes after treatment with tested covering materials, as well as in the untreated bone lesions.

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“…All surgical procedures were performed according to standard protocol. This protocol has been published several times [27, 36, 38–40]. …”

Section: Methodsmentioning

confidence: 99%

Bone Regeneration after Treatment with Covering Materials Composed of Flax Fibers and Biodegradable Plastics: A Histological Study in Rats

Gredes

Kunath

Gedrange

et al. 2016

BioMed Research International

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“…Decisive growth factors for muscle differentiation, regeneration, and vascularization are, among others, insulin like growth factors (IGF), vascular endothelial growth factor (VEGF) for positive adjustment and myostatin (GDF8) as a negative growth factor (Gredes et al, 2009(Gredes et al, , 2012. Endogenously produced IGF1 and IGF2 can exert a supportive effect on skeletal muscle differentiation (Florini et al, 1991a,b,c) and IGF1 might additionally play a predominant role in protecting cells from death mediated by myostatin (Yang et al, 2007).…”

Section: Expression Of Growth Factorsmentioning

confidence: 99%

Interrelationship between bone substitution materials and skeletal muscle tissue

Kunert‐Keil

Botzenhart

Gedrange

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

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Influence of BONITmatrix® and OSSA NOVA on the expression of bone specific genes

Gredes¹,

Kracht²,

Gedrange³

et al. 2012

Annals of Anatomy - Anatomischer Anzeiger

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Bone substitution materials on the basis of BONITmatrix® up-regulate mRNA expression of IGF1 and Col1a1

Cited by 9 publications

References 44 publications

Bone Regeneration after Treatment with Covering Materials Composed of Flax Fibers and Biodegradable Plastics: A Histological Study in Rats

Bone Regeneration after Treatment with Covering Materials Composed of Flax Fibers and Biodegradable Plastics: A Histological Study in Rats

Interrelationship between bone substitution materials and skeletal muscle tissue

Influence of BONITmatrix® and OSSA NOVA on the expression of bone specific genes

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