Bone tissue and histological and molecular events during development of the long bones

Blumer, Michael

doi:10.1016/j.aanat.2021.151704

Cited by 32 publications

(19 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skeletal long bone formation starts from chondrogenic cell condensation and is subsequently transformed into differentiated chondrocytes surrounded by a thin tissue sheath, termed the perichondrium [ 135 ]. The terminal step of the chondrocyte differentiation process is hypertrophy, after which the cartilage is replaced by bone tissue.…”

Section: Periosteum- and Perichondrium-derived Stem Cellsmentioning

confidence: 99%

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

Kurenkova

Романова

Kibirskiy

et al. 2022

IJMS

View full text Add to dashboard Cite

Damaged hyaline cartilage gradually decreases joint function and growing pain significantly reduces the quality of a patient’s life. The clinically approved procedure of autologous chondrocyte implantation (ACI) for treating knee cartilage lesions has several limits, including the absence of healthy articular cartilage tissues for cell isolation and difficulties related to the chondrocyte expansion in vitro. Today, various ACI modifications are being developed using autologous chondrocytes from alternative sources, such as the auricles, nose and ribs. Adult stem cells from different tissues are also of great interest due to their less traumatic material extraction and their innate abilities of active proliferation and chondrogenic differentiation. According to the different adult stem cell types and their origin, various strategies have been proposed for stem cell expansion and initiation of their chondrogenic differentiation. The current review presents the diversity in developing applied techniques based on autologous adult stem cell differentiation to hyaline cartilage tissue and targeted to articular cartilage damage therapy.

show abstract

Section: Periosteum- and Perichondrium-derived Stem Cellsmentioning

confidence: 99%

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

Kurenkova

Романова

Kibirskiy

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…In fact, bone fracture healing relying on mesenchymal stem cells (MSCs) derived osteoblasts performance, can occur through two different mechanisms: intramembranous (involved in the formation of flat bones such as skull bones and clavicles) and endochondral (in long bones such as femur and tibia) bone formation. While the intramembranous ossification directly forms the bone from MSCs that are differentiated into osteoblasts, for endochondral bone formation, there are two key players required; the presence of cartilage, and the vascularization process [ 2 , 3 ]. Indeed, angiogenesis (the formation of new blood vessels from pre-existing ones) is a key component in bone repair, since blood vessels bring oxygen and nutrients to the regenerating tissue [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

View full text Add to dashboard Cite

Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

show abstract

“…These genes are normally expressed in chondrocytes and were downregulated in P1 versus AMC. Chondrocytes are the only cell type present in cartilage and are needed for the development of the skeletal system through endochondral ossification (41).…”

Section: Resultsmentioning

confidence: 99%

Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome

McQuaid¹,

Ahmed²,

Tran³

et al. 2022

JCI Insight

View full text Add to dashboard Cite

Bone tissue and histological and molecular events during development of the long bones

Cited by 32 publications

References 98 publications

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome

Contact Info

Product

Resources

About