Bone Turnover Markers Do Not Predict Stress Fracture in Elite Combat Recruits

Yanovich, Ran; Evans, Rachel; Friedman, Eitan; Moran, Daniel S.

doi:10.1007/s11999-012-2727-3

Cited by 21 publications

(22 citation statements)

References 25 publications

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“…In contrast, measurements of u-NTX obtained the day after moderate exercise were reported to be no different from measurements obtained before exercise [28]. Although it was reported that bone metabolism markers are not suitable prediction markers for stress fracture [29], the bone metabolism marker used in the previous study was a serum marker (TRACP-5b, CTX), and u-NTX was not measured. Based on previous studies, TRACP-5b increases when there is a history of stress fracture, but it may not be reliable on the onset of stress fracture [27], whereas in our study u-NTX became higher when stress fracture develops, indicating that there are certain characteristic bone resorption markers.…”

Section: Discussionmentioning

confidence: 83%

Stress Fracture Influences Bone Resorption marker (u-NTX) in Female Long Distance Runners

et al. 2017

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In this study, we aim to clarify the influence based on bone resorption markers at onset of stress fracture. Also, we will clarify the state of the bone resorption markers of female long distance runners who have a history of stress fracture and also ones who routinely practices running long distances. Participants comprised 19 female long distance athletes. The survey period was 2011–2014, and we measured u-NTX as a bone resorption marker at least twice a year, taking the mean±SD of the periodic measured values without stress fracture as the mean value. Measurements were collected sample when stress fractures developed. 132 u-NTX measurements were taken from 19 participants. As a result, the average was 41.03±12.31 nmolBCE/mmolCRE (Q1: 33.15, Q2: 40.55, Q3: 47.95). In six of the 19 participants, u-NTX could be measured following a stress fracture. The mean value of u-NTX for those participants was 40.16±9.10 nmolBCE/mmolCRE, increasing to 64.08±16.07 nmolBCE/mmol CRE with the stress fracture (p<0.01). The findings showed that, in adult female long distance runners, u-NTX values when there was no stress fracture were within the standard value for mean premenopausal women, but increased when the athletes suffered from a stress fracture.

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Section: Discussionmentioning

confidence: 83%

Stress Fracture Influences Bone Resorption marker (u-NTX) in Female Long Distance Runners

et al. 2017

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“…2008, Yanovich et al. 2013). In our study, all 3 markers of bone formation—bone-specific alkaline phosphatase, osteocalcin, and P1NP—were elevated in patients with stress fractures, but we ascribe these elevations mainly to ongoing fracture healing, where elevated levels can be seen even after 1 year (Ingle et al.…”

Section: Discussionmentioning

confidence: 99%

Women with previous stress fractures show reduced bone material strength

Sosa¹,

Eriksen²

2016

Acta Orthopaedica

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Background and purpose — Bone fragility is determined by bone mass, bone architecture, and the material properties of bone. Microindentation has been introduced as a measurement method that reflects bone material properties. The pathogenesis of underlying stress fractures, in particular the role of impaired bone material properties, is still poorly understood. Based on the hypothesis that impaired bone material strength might play a role in the development of stress fractures, we used microindentation in patients with stress fractures and in controls.Patients and methods — We measured bone material strength index (BMSi) by microindentation in 30 women with previous stress fractures and in 30 normal controls. Bone mineral density by DXA and levels of the bone markers C-terminal cross-linking telopeptide of type-1 collagen (CTX) and N-terminal propeptide of type-1 procollagen (P1NP) were also determined.Results — Mean BMSi in stress fracture patients was significantly lower than in the controls (SD 72 (8.7) vs. 77 (7.2); p = 0.02). The fracture subjects also had a significantly lower mean bone mineral density (BMD) than the controls (0.9 (0.02) vs. 1.0 (0.06); p = 0.03). Bone turnover—as reflected in serum levels of the bone marker CTX—was similar in both groups, while P1NP levels were significantly higher in the women with stress fractures (55 μg/L vs. 42 μg/L; p = 0.03). There was no correlation between BMSi and BMD or bone turnover.Interpretation — BMSi was inferior in patients with previous stress fracture, but was unrelated to BMD and bone turnover. The lower values of BMSi in patients with previous stress fracture combined with a lower BMD may contribute to the increased propensity to develop stress fractures in these patients.

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“…Ruohola et al found no difference in TRAP between stress fractured military recruits and controls, though recruits with proportionally increasing TRAP during training were more likely to suffer a stress fracture [20]. A recent study in Israeli male military recruits (n = 69) found no differences in CTx and two other bone turnover markers between stress fractured recruits and non-fractured recruits [22]. Moreover, in a twelve month prospective study in athletes, measurements of bone turnover were found not to be useful in predicting the likelihood of stress fracture occurrence [38].…”

Section: Bone Resorptionmentioning

confidence: 95%

“…Previous studies have reported conflicting findings with regards to longitudinal changes in bone turnover markers during military training, as well as with respect to differences between stress fracture cases and controls [19][20][21][22]. Therefore the relevance of bone turnover markers in predicting stress fracture risk remains unclear.…”

Section: Bone Turnover Markersmentioning

confidence: 99%

Fundamental differences in axial and appendicular bone density in stress fractured and uninjured Royal Marine recruits — A matched case–control study

Davey¹,

Lanham-New²,

Shaw³

et al. 2015

Bone

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Bone Turnover Markers Do Not Predict Stress Fracture in Elite Combat Recruits

Abstract: Level II prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.

Cited by 21 publications

References 25 publications

Stress Fracture Influences Bone Resorption marker (u-NTX) in Female Long Distance Runners

Stress Fracture Influences Bone Resorption marker (u-NTX) in Female Long Distance Runners

Women with previous stress fractures show reduced bone material strength

Fundamental differences in axial and appendicular bone density in stress fractured and uninjured Royal Marine recruits — A matched case–control study

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