Bone Turnover Markers Relations to Postmenopausal Osteoporosis

Jovcevska, Jasmina Mecevska; Stratrova, Slavica Shubeska; Gjorgovski, Icko; Gruev, Todor; Kotevska, Mimoza Nikolovska; Janićević-Ivanovska, Daniela; Petrovska, Emilija

doi:10.2478/v10011-009-0012-0

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…Values of bone metabolism markers in our study showed a statistically significant difference in the level of bone resorption marker, b-CrossLaps, between the groups of amenorrheic and oligomenorrheic sports women in comparison to eumenorrheic women, both sportswomen and those in the control group. Values in the groups of interviewees with menstrual dysfunctions were significantly above the recom mended upper values (b-CTx 0.299 ng/mL and OC 15-46 ng/mL) (24). Accelerated resorption was accompanied with acce le rated bone formation, which is obvious from the increased osteocalcin level value.…”

Section: Discussionmentioning

confidence: 60%

“…Accelerated resorption was accompanied with acce le rated bone formation, which is obvious from the increased osteocalcin level value. However, the values of b-CTx in amenorrheic and oligomenorrheic women were increased to such an extent (b-CTx 1.501 ± 0.50 ng/mL and b-CTx 0.9788 ± 0.33 ng/mL) that they surpassed the values found in women with diagnosed postmenopausal osteoporosis (24). These findings indicate a disturbed balance between the formation and the resorption of bones in the examined sample, negative bone metabolism and possibility of bone mass loss.…”

Section: Discussionmentioning

confidence: 74%

“…Fewer menstrual dysfunctions in the sport dance subgroup are probably due to lower intensity of the training burden, which also conforms to a lower competition ranking of these interviewees. Previous researches docu men ted the influence of hypoes tro genism on the increase of the level of bone resorption markers, reduction of BMD and the consequential occurrence of osteo po rosis in postmenopausal women (22)(23)(24). However, very few researches have targeted the dynamics of bone metabolism markers in sports women with menstrual dysfunctions or secon dary osteoporosis (25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

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Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Ponorac¹,

Rašeta²,

Radovanović³

et al. 2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Dobro je poznata ~injenica da su sport ist kinje sa neredovnim menstrualnim ciklusom izlo`ene riziku od smanjenja ko{tane mineralne gustine i posledi~no osteoporozi. Pra}enje nivoa biohemijskih markera ko {tanog metabolizma omogu}ava razumevanje dina m i ~kih promena tokom procesa remodeliranja kosti. Ciljevi spro vedenog istra`ivanja bili su: utvrditi prevalence men stru alnih poreme}aja na uzorku sportistkinja i kontrolne grupe, kao i odrediti nivoe markera ko{tanog metabolizma u grupama ispitanica sa menstrualnim disfunkcijama. Ispi tanice (n=117) bile su podeljene u dve grupe, ekspe rimentalnu (S) (n=84) podeljenu u tri podgrupe (34 sportistkinje igara sa loptom, 27 atleti~arki i 23 takmi~arke u sportskom plesu) i kontrolnu grupu (C) (n=34). Za odre|ivanje menstrualnog profila i poreme}aja menstrual nog ciklusa kori{}en je upitnik. Odre|en je nivo srednjeg fragmenta osteokalcina (N-MID osteokalcin) kao markera formiranja kosti i b-CrossLaps (b-CTx -marker resorpcije kosti) elektroluminiscentnom imunohemijskom metodom na automatskom aparatu Elecsys 1010. Primarna ame noreja na|ena je kod 7 (8,33%) a oligomenoreja kod 11 (13,09%) sportistkinja, {to je statisti~ki zna~ajno vi{a incidenca u odnosu na kontrolnu grupu. Vrednosti markera ko{tanog metabo lizma su pokazale statisti~ki zna~ajnu razliku u nivou mar ke ra resorpcije kosti, b-CrossLaps, izme|u grupa ameno rei~ nih i oligomenorei~nih sportistkinja u odnosu na eume no rei ~ne ispitanice, kako sportistkinje tako i kontrolnu grupu. Ubrzanu resorpciju je pratilo i ubrzano formiranje kosti (pove}ane Summary: It is a well known fact that sportswomen with irregular menstrual cycle are exposed to the risk of dimi nished bone mineral density, and consequentially osteoporosis may appear. Monitoring of the levels of biochemical markers of bone metabolism enables understanding of the dynamic changes during the bone remodeling process. The objectives of the conducted research were to determine the prevalence of menstrual dysfunctions in a sportswomen sample and a control group, and also to determine the levels of bone metabolism markers in groups of women with menstrual dysfunctions. The women (n=117) were separated into two groups, the experi men tal group (S) (n=84) comprised of three subgroups of sports women (34 women who play ball game sports, 27 athletes and 23 sport dancers) and the control group (C) (n=34). To establish the menstrual profile and dys function of the menstrual cycle, we used a very detailed questionnaire. The level of mid-fragment osteo calcin (N-MID osteocalcin) as a mar ker of bone forma tion was deter mined, as well as b-Cross Laps (bCTx-bone resorption marker) via the electro luminescent immunoche mistry method on an Elecsys 1010 automated machine. Pri mary amenorrhea was found in 7 (8.33%) and oligome norrhea in 11 (13.09%) sportswomen, which was statistically a much higher incidence (p<0.05) than in the control group (0/34). Values of bone metabolism markers showed a sta tistically significant difference in the level of the...

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Ponorac¹,

Rašeta²,

Radovanović³

et al. 2011

Journal of Medical Biochemistry

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“…Osteoporosis is a common skeletal disorder that shows characteristics of low bone mineral mass and microarchitectural deterioration of bone tissue, which subsequently increases the fragility of the affected bone, leading to an increased risk of fracture (Bonnick et al, 2010;Holroyd et al, 2008;Jovcevska et al, 2009;Mihaljevic et al, 2009;Ozdurak et al, 2003). Bone strength is a reflection of the integration of bone density and bone quality (Iwamoto et al, 2009).…”

Section: Diagnosismentioning

confidence: 99%

Assessment of Bone Mineral Density in Forearms of Collegiate Ten Pin Bowlers

Fryman¹,

Winklepleck²,

Patterson³

2010

Medicine &Amp; Science in Sports &Amp; Exercise

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research, Bryce Winklepleck for his assistance in the data collection, Brett Williams for his assistance in the statistical analysis and Ashley Hervey for her assistance in the data collection, and most importantly her friendship and support as we went through this process together. I would also like to thank the participants of this study for their willing participation in the research. A special thanks to my husband, family and friends for their devoted faith and support in my education and life"s journey. v ABSTRACT Studies have demonstrated the effect of dominance on bone mineral density (BMD) of both weight bearing and non-weight bearing limbs and the effect of physical activity and specific sports, such as tennis, gymnastics, and volleyball on bmd of the predominantly used limb(s) versus non-used limb(s). Like tennis and volleyball, the Wichita State University (WSU) bowling team performs a high volume of repetitive use of their bowling arm on a regular basis. This is the first study to investigate the effect of ten-pin bowling at an elite collegiate level on BMD of the bowling arm compared to the non-bowling arm. Dual Energy X-ray Absorptiometry Unit (Hologic QDR 4500W Elite) was used to assess BMD of bilateral arms (whole body scan) and bilateral forearms (forearm scan) of 25 (N=13 males, N=12 females) collegiate bowlers (20.72 ± 1.46 yrs). In this study, the forearm scans showed significantly greater (p<0.05) BMD in the bowling arm (0.635 ± .05 g•cm-2) compared to the non-bowling arm (0.618 ± .06 g•cm-2) of both male and female bowlers. However, when separated by gender, the female bowling arm showed a significantly greater difference between arms (4.1 ± 3.1% difference, p<0.05) and compared to the males (1.5 ± 2.6% difference, p<0.05). Whole body scans of the left and right arms were also assessed and similar results were observed in the bowling arm compared to the non-bowling arms of males (3.81 ± 5.19%, p<0.05) and females (4.15 ± 2.54%, p<0.05). In conclusion, the female elite level collegiate ten-pin bowlers demonstrate an increased BMD in the bowling forearm when compared to the non-bowling forearm. vi

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“…Hal ini sesuai dengan penelitian sebelumnya yang menunjukkan bahwa pada pasien osteoporosis terjadi peningkatan yang signifikan dari β-CTx yang menunjukkan terjadinya peningkatan resorpsi tulang. 14,15 Berdasarkan uji kesamaan dua ratarata (α=0,05) diperoleh hasil nilai β-CTx …”

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N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal Women

Halimah

Rositawati²,

Pratiwi³

2016

Indones J Clin Pharm

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AbstrakOsteocalcin merupakan senyawa penanda untuk pembentukan tulang sedangkan β-CrossLaps (β-CTx) merupakan fragmen hasil pemecahan kolagen tipe 1. Tujuan penelitian ini yaitu untuk menentukan N-MID osteocalcin (N-MID Oc) dan β-CTx sebagai penanda biokimia Bone Turn Over untuk deteksi dini osteoporosis pada wanita menopause. Nilai N-MID Oc dalam serum ditentukan dengan pereaksi Elecsys N-MID Osteocalcin kit dan nilai β-CTx dalam serum ditentukan dengan pereaksi Elecsys β-CROSSLAPS kit yang bekerja berdasarkan prinsip Electrochemiluminescence Immunoassay (ECLIA). Data yang diperoleh diuji dengan menggunakan Uji-T. Sampel yang dikumpulkan berasal dari wanita normal, osteopenia, dan penderita osteoporosis pada wanita menopause. Hasil penelitian menunjukkan terdapat perbedaan nilai N-MID Oc pada wanita menopause normal dengan wanita menopause osteopenia, wanita menopause normal dengan wanita menopause penderita osteoporosis dan wanita menopause osteopenia dengan wanita menopause penderita osteoporosis (α=0,05), sedangkan pada nilai β-CTx terdapat perbedaan antara wanita menopause normal dengan wanita menopause osteopenia, wanita menopause osteopenia dengan wanita menopause osteoporosis, tetapi antara wanita menopause osteopenia dengan wanita menopause osteoporosis tidak menunjukkan perbedaan (α=0,05). Penelitian ini menunjukkan bahwa N-MID Oc dan β-CTx dapat dijadikan parameter untuk deteksi dini osteoporosis. N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal WomenAbstract Osteocalcin is a marker compound for bone formation while the β-crosslaps a fragment split from collagen type 1. The aims of this study were to determined of the value of N-MID osteocalcin (N-MID Oc) and β-CTx as a biochemical marker of Bone Turn Over as early detection of osteoporosis in postmenopausal women. The value of N-MID Oc in serum was determined by reagent Elecsys N-MID Osteocalcin kit and the value of β-CTx in serum was determined by reagent Elecsys β-Crosslaps kit which works with the principle of Electrochemiluminescence Immunoassay (ECLIA). The data obtained were examined using T-test. The sample collected from normal, osteopenia, and osteoporotic in menopausal women. There were a significant difference N-MID Oc between normal, osteopenia, and osteoporotic in menopausal women (α=0,05). There were significant differences of β-CTx between normal and osteopenia, normal and osteoporosis but between osteopenia and osteoporotic menopausal women not showed any difference (α=0,05). N-MID Osteocalcin (N-MID Oc) and β-CTx can be used as parameter for early detection of osteoporosis.

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Bone Turnover Markers Relations to Postmenopausal Osteoporosis

Cited by 4 publications

References 19 publications

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Assessment of Bone Mineral Density in Forearms of Collegiate Ten Pin Bowlers

N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal Women

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