Bone union with an in situ spacer after the first stage of the induced membrane technique

Azi, Matheus Lemos; Teixeira, Armando Augusto de Almeida; Cotias, Ricardo Britto; Joeris, Alexander; Kfuri, Maurício

doi:10.1016/s0020-1383(17)30770-2

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…In contrast to the reviewed literature wherein, CA-based material was most commonly used, PMMAbased adhesives and cement have been more commonly utilised in the weight-bearing areas. [53][54][55][56][57][58] Modification of PMMA has been extensively researched by incorporating substances like polyethylene glycol hydrogel, CPC, magnesium, carboxymethylcellulose, alginate, gelatin microparticles, platelet gel, zirconium dioxide, and gentamicin to enhance their properties like handling, porosity, injectability, biodegradability, and antibacterial action. 53,55 Of the 24 excluded articles, only 2 reported human clinical application, both of them using PMMA adhesive for the purpose.…”

Section: Materials Of Interestmentioning

confidence: 99%

“…53,55 Of the 24 excluded articles, only 2 reported human clinical application, both of them using PMMA adhesive for the purpose. 53,57 Legend: CT: Computed Tomography, SEM:Scanning Electron Microscopy commonly used and too demonstrated chemical additions to achieve improved characteristics and bonding strength. 59,60 All these studies strongly supported the use of these materials inweight-bearing regions however, elaborating more about the same does not fall under the scope of the current work.…”

Section: Materials Of Interestmentioning

confidence: 99%

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Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review

Bhandari

Jain²,

Muktawat³

et al. 2022

Def. Life. Sc. Jl.

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The reduction and stabilisation of fractured bone fragments have always been a challenging task for thesurgeon. A micro-platesystem for maxillofacial fracture treatment provides excellent results. However, plates and screws are difficult toadapt to the thin bone, and small fragments often lead to the weakening of bone causing secondary fractures. Surgical bone adhesives promise as a viable alternative for issues with micro-plates, but a lotremains desired for successful usefor clinical application. The present systematic review aims to identify the bone adhesive materials available at various stages in animal or human models in the last decade and enumerate their characteristics for potential use in non-load bearing maxillofacial fractures. PubMed electronic database searched using a combination of keywords to identify English language articles between January 2011 and December 2020 yielded a total of 1204 records, of which 15 were included for final review after applying PRISMA guidelines. Cyanoacrylate was the commonly used adhesive material followed by fibrin glue and calcium phosphate-based materials. Although encouraging, results with each material still lack human randomised control trials thus presenting inconclusive evidence. Studies on these lines are suggested along with the development of newer materials to overcome the shortcomings in the currently available systems.

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Section: Materials Of Interestmentioning

confidence: 99%

Section: Materials Of Interestmentioning

confidence: 99%

Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review

Bhandari

Jain²,

Muktawat³

et al. 2022

Def. Life. Sc. Jl.

View full text Add to dashboard Cite

show abstract

“…Inappropriate treatments often lead to recurrent local inflammation and serious complications such as muscle atrophy or even amputation (4). Traditional treatment methods, such as bone graft surgery, are more effective in patients with small bone defects than in patients with large bone defects such as femoral and tibia defects due to limited resources of donor bone (5–7). Skeletal traction is commonly used for the treatment of large bone defects in clinic.…”

Section: Introductionmentioning

confidence: 99%

Masquelet induced membrane technique for treatment of rat chronic osteomyelitis

Cui

Peng

et al. 2018

Exp Ther Med

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The application value of Masquelet induced membrane technique for the treatment of rat chronic osteomyelitis was explored. A total of 180 male Sprague-Dawley (SD) rats were randomly divided into sham operation group (control group), chronic osteomyelitis model group (model group) and Masquelet induced membrane therapy + chronic osteomyelitis model group (observation group); 60 rats in each group. A rat model of traumatic osteomyelitis was established using a modified blunt trauma method in model and observation group. All rats in observation group were treated with membrane induction technology while in the control group they were not. Postoperative complications, bone healing time and functional status of the affected limbs were recorded. After surgery, no obvious perioperative complications occurred in most of the rats, except that 5 rats experienced partial necrosis at the edge of the flap, and 3 experienced superficial infection around the incision site in the ilium. Primary bone healing was achieved in 50 rats with an average healing time of 15 weeks. Among them, 38 rats restored weight-bearing function after 20 weeks. Seven rats experienced infection after surgery, but complete bone healing was achieved after treatment with induced membrane technique again. Following treatment with induced membrane technique, the rat body weight, body temperature and the number of bacteria in the wound decreased over time. In conclusion, Masquelet induced membrane technique is effective for the treatment of large bone defects in rats after traumatic osteomyelitis. This technique significantly shortens the treatment cycle. The surgical procedure is simple, and the incidence of postoperative complications is low.

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Construction of developmentally inspired periosteum-like tissue for bone regeneration

Dai

Deng

et al. 2022

Bone Res

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The periosteum, a highly vascularized thin tissue, has excellent osteogenic and bone regenerative abilities. The generation of periosteum-mimicking tissue has become a novel strategy for bone defect repair and regeneration, especially in critical-sized bone defects caused by trauma and bone tumor resection. Here, we utilized a bone morphogenetic protein-2 (BMP-2)-loaded scaffold to create periosteum-like tissue (PT) in vivo, mimicking the mesenchymal condensation during native long bone development. We found that BMP-2-induced endochondral ossification plays an indispensable role in the construction of PTs. Moreover, we confirmed that BMP-2-induced PTs exhibit a similar architecture to the periosteum and harbor abundant functional periosteum-like tissue-derived cells (PTDCs), blood vessels, and osteochondral progenitor cells. Interestingly, we found that the addition of chondroitin sulfate (CS), an essential component of the extracellular matrix (ECM), could further increase the abundance and enhance the function of recruited PTDCs from the PTs and finally increase the regenerative capacity of the PTs in autologous transplantation assays, even in old mice. This novel biomimetic strategy for generating PT through in vivo endochondral ossification deserves further clinical translation.

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Bone union with an in situ spacer after the first stage of the induced membrane technique

Cited by 3 publications

References 14 publications

Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review

Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review

Masquelet induced membrane technique for treatment of rat chronic osteomyelitis

Construction of developmentally inspired periosteum-like tissue for bone regeneration

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