2014
DOI: 10.1128/cvi.00665-13
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Bordetella pertussis Proteins Dominating the Major Histocompatibility Complex Class II-Presented Epitope Repertoire in Human Monocyte-Derived Dendritic Cells

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Cited by 13 publications
(7 citation statements)
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“…Indeed other pertussis-antigens, not used in this study, have been described in a recently published paper, including two envelope proteins, i.e., putative periplasmic protein (PPP) and putative peptidoglycan-associated lipoprotein (PAL), and two cytosolic proteins, i.e., 10kDa chaperonin groES protein (groES) and adenylosuccinate synthetase (ASS) [38]. It is possible that these antigens could contribute to the pertussis-specific immune response in wP-primed individuals.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed other pertussis-antigens, not used in this study, have been described in a recently published paper, including two envelope proteins, i.e., putative periplasmic protein (PPP) and putative peptidoglycan-associated lipoprotein (PAL), and two cytosolic proteins, i.e., 10kDa chaperonin groES protein (groES) and adenylosuccinate synthetase (ASS) [38]. It is possible that these antigens could contribute to the pertussis-specific immune response in wP-primed individuals.…”
Section: Discussionmentioning
confidence: 99%
“…Yet proteins residing in the cytosol, nucleus or mitochondria can also be presented by HLA class II molecules, primarily through autophagy ( 9 11 ). Multiple studies have mapped the HLA class II ligandome of antigen presenting cells in the context of infectious pathogens ( 12 ), autoimmune diseases ( 13 17 ) or cancer ( 14 , 18 , 19 ), or those that are essential for self-tolerance in the human thymus ( 3 , 20 ). Notwithstanding these efforts, and certainly not in line with the extensive knowledge on the HLA class I ligandome ( 21 ), the nature of the HLA class II-presented peptide repertoire and particular its relationship to the cellular source proteome remains poorly understood.…”
mentioning
confidence: 99%
“…To advance our knowledge on the HLA-DR ligandome on activated DC without having to deal with limitations in cell yield from peripheral human blood ( 12 , 21 , 22 ) or tissue isolates ( 3 ), we explored the use of MUTZ-3 cells. This cell line has been used as a model of human monocyte-derived DCs.…”
mentioning
confidence: 99%
“… 2013 ; Stenger et al. 2014 ), however, is still very limited (De Magistris et al. 1989 ; Peppoloni et al.…”
Section: Immunological Evaluation Of New Pertussis Vaccines In (Pre-)mentioning
confidence: 99%