Boron Compounds in Molecular Imaging

Das, Bhaskar C.; Ojha, Devi Prasan; Das, Sasmita; Evans, Todd

doi:10.1002/9781119275602.ch2.4

Cited by 4 publications

(3 citation statements)

References 77 publications

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“…Veronica Torresan et al generate iron−boron (Fe−B) NPs and realize the MR imaging by using the magnetic response of the nanoparticles. 123 18 FBPA-PET is a useful and reliable imaging tool for BNCT treatment; 124 Niranjan Meher and his research team also designed the CB with radiometal chelator deferoxamine B to achieve the 18 FBPA-PET imaging function. 125 In addition, many scientists also focus on directly modifying boron compounds utilizing the fluorophore to give imaging effects themselves (Figure 5).…”

Section: Discussionmentioning

confidence: 99%

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with other traditional methods. It has been considered as one of the promising methods for the treatment of various cancers. Measuring 10B concentrations is vital for BNCT. However, the existing technology and equipment cannot satisfy the real-time and accurate measurement requirements, and more efficient methods are in demand. The development of methods and imaging applied in BNCT to help measure boron concentration is described in this review.

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Section: Discussionmentioning

confidence: 99%

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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“…3 In particular, the ability of organoboron compounds to participate in various organic reactions, such as hydroboration, Suzuki–Miyaura coupling, and Chan–Lam coupling, has enabled robust chemical transformations to convert the boron substituent to another functional moiety. 4 Moreover, the indispensable role of organoboron compounds in boron neutron capture therapy, 5 molecular imaging, 6 and medicines 7 could not be overstated. Therefore, it is unsurprising that the synthesis of organoboron compounds has garnered significant interest.…”

Section: Introductionmentioning

confidence: 99%

Radical hydroboration for the synthesis of organoboron compounds

Phang,

Jin,

Zhang

et al. 2024

Chem. Commun.

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“…The covalent ligands present at the boron center can also form strong hydrogen bonds, which can improve effective coordination of active sites in a drug delivery process. In general, based on the literature, these bimodal interactions can be broadly classified into two categories: (i) primary and (ii) secondary interactions [4][5][6].The chemistry is evident from various studies on the behavior of boronic acid/ester present in various drug molecules [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective

et al. 2022

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A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure–activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer’s agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects.

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Boron Compounds in Molecular Imaging

Cited by 4 publications

References 77 publications

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

Radical hydroboration for the synthesis of organoboron compounds

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective

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