Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms

Mohammed, Eslam Essam; Türkel, Nezaket; Yigit, Ummuhan Miray; Dalan, Altay Burak; Şahın, Fikrettin

doi:10.1007/s12011-023-03632-0

Cited by 8 publications

(6 citation statements)

References 70 publications

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“…These approved agents could be designed to carry boron atoms, to combine this strategy with BNCT, increasing therapeutic effects and overcoming limitations of both therapies. In relation to this topic, a recent study by Mohammed et al [ 170 ] with boron derivatives (sodium pentaborate pentahydrate (SPP) and sodium perborate tetrahydrate (SPT)) demonstrated that these compounds induced proliferation suppression and apoptosis in two human breast cancer cell lines. However, these boron compounds induced stimulatory effects on the PD1/PDL1 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Hughes

2023

Cancers

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Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation. The recent initiation of BNCT clinical trials employing hospital-based accelerators rather than nuclear reactors as the neutron source will conceivably pave the way for new and more numerous clinical trials, leading up to much-needed randomized trials. In this context, it would be interesting to consider the implementation of new boron compounds and strategies that will significantly optimize BNCT. With this aim in mind, we analyzed, in this review, those articles published between 2020 and 2023 reporting new boron compounds and strategies that were proved therapeutically useful in in vitro and/or in vivo radiobiological studies, a critical step for translation to a clinical setting. We also explored new pathologies that could potentially be treated with BNCT and newly developed theranostic boron agents. All these radiobiological advances intend to solve those limitations and questions that arise during patient treatment in the clinical field, with BNCT and other therapies. In this sense, active communication between clinicians, radiobiologists, and all disciplines will improve BNCT for cancer patients, in a cost- and time-effective way.

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Section: Discussionmentioning

confidence: 99%

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Hughes

2023

Cancers

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Section: Boronmentioning

confidence: 99%

“…A study from 2023 by Mohammed et al aimed to determine the potential effects of boron derivatives, sodium pentaborate pentahydrate, and sodium perborate tetrahydrate on breast cancer cell lines, PD-1/PD-L1 expression, and activated T cells [152]. Their anticarcinogenic effects have been demonstrated in both TNBC cells and ER+ cancer cells [152]. Both compounds induced apoptosis in breast cancer cells through the downregulation of the monopolar spindle-one-binder 1 (MOB1) protein, as well as antiproliferative effects by inducing a decrease in the expression of the CYR61, CTGF, and BIRC-5 genes [152].…”

Section: Boronmentioning

confidence: 99%

“…Their anticarcinogenic effects have been demonstrated in both TNBC cells and ER+ cancer cells [152]. Both compounds induced apoptosis in breast cancer cells through the downregulation of the monopolar spindle-one-binder 1 (MOB1) protein, as well as antiproliferative effects by inducing a decrease in the expression of the CYR61, CTGF, and BIRC-5 genes [152]. Sodium pentaborate pentahydrate and sodium perborate tetrahydrate can inhibit breast cancer progression but also have the potential to cause side effects by stimulating PD-1/PD-L1 expression and inhibiting the release of cytolytic cytokines [152].…”

Section: Boronmentioning

confidence: 99%

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Micronutrient Status and Breast Cancer: A Narrative Review

Forma,

Grunwald,

Zembala

et al. 2024

IJMS

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Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.

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“…Importantly, boron is a crucial element in the potential induction of the cell cycle entry of cardiomyocytes, which could lead to the regeneration of cardiac tissue in the aftermath of injury. Mohammed et al (2023) found that boron derivatives sodium pentaborate pentahydrate (500 μg/mL) and sodium perborate tetrahydrate (50 μg/mL) suppressed proliferation and induced apoptosis in breast cancer cell lines by means of suppressing the monopolar spindle-one-binder (MOB1) protein [ 11 ]. However, the upregulation of programmed death-ligand 1 (PD-L1) protein and downregulation of pro-inflammatory cytokines were observed, leading to the suppression of effector T cells that were specifically activated against breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of Rat Duodenum Reveals the Modulatory Effect of Boron Supplementation on Immune Activity

Zhao,

Chen,

Han

et al. 2023

Genes

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The proper supplementation of boron, an essential trace element, can enhance animal immune function. We utilized the method of TMT peptide labeling in conjunction with LC-MS/MS quantitative proteomics for the purpose of examining the effects of boric acid on a rat model and analyzing proteins from the duodenum. In total, 5594 proteins were obtained from the 0, 10, and 320 mg/L boron treatment groups. Two hundred eighty-four proteins that exhibit differential expression were detected. Among the comparison, groups of 0 vs. 10 mg/L, 0 vs. 320 mg/L, and 10 vs. 320 mg/L of boron, 110, 32, and 179 proteins, respectively, demonstrated differential expression. The results revealed that these differential expression proteins (DEPs) mainly clustered into two profiles. GO annotations suggested that most of the DEPs played a role in the immune system process, in which 2′-5′-oligoadenylate synthetase-like, myxovirus resistance 1, myxovirus resistance 2, dynein cytoplasmic 1 intermediate chain 1, and coiled-coil domain containing 88B showed differential expression. The DEPs had demonstrated an augmentation in the signaling pathways, which primarily include phagosome, antigen processing, and presentation, as well as cell adhesion molecules (CAMs). Our study found that immune responses in the duodenum were enhanced by lower doses of boron and that this effect is likely mediated by changes in protein expression patterns in related signaling pathways. It offers an in-depth understanding of the underlying molecular mechanisms that lead to immune modulation in rats subjected to dietary boron treatment.

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Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms

Cited by 8 publications

References 70 publications

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

Micronutrient Status and Breast Cancer: A Narrative Review

Proteomic Analysis of Rat Duodenum Reveals the Modulatory Effect of Boron Supplementation on Immune Activity

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