Boron Nitride Nanotubes: A Novel Vector for Targeted Magnetic Drug Delivery

Ciofani, Gianni; Raffa, Vittoria; Yu, Jun; Chen, Ying; Obata, Yosuke; Takeoka, Shinji; Menciassi, Arianna; Cuschieri, Alfred

doi:10.2174/157341309787314557

Cited by 92 publications

(51 citation statements)

References 26 publications

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“…Thus the BNNT usage is preferred, as far as nanotubebased device applications are expected at high temperatures and in chemically active and/or hazardous environments. 9 Although their use as vectors for drug delivery 10 or MRI contrast agents is foreseen, 11 the application of BNNTs in biomedicine remains largely unexplored. In particular, the interaction of BNNTs with living cells has not been addressed yet extensively.…”

Section: à5mentioning

confidence: 99%

In Vitro Investigation of the Cellular Toxicity of Boron Nitride Nanotubes

et al. 2011

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Nanotubes present one of the most promising opportunities in nanotechnology with a plethora of applications in nanoelectronics, mechanical engineering, as well as in biomedical technology. Due to their structure and some physical properties, boron nitride (BN) nanotubes (BNNTs) possess several advantages over carbon nanotubes (CNTs), and they are now commercially produced and used on a large scale. The human and environmental exposure to BN nanomaterials is expected to increase in the near future, and their biological responses need to be examined. Using complementary assays, we have extensively investigated the effects of BNNTs on the viability and metabolic status of different cell types: on the one hand, the effects on cells present in the lung alveoli, and on the other hand, on human embryonic kidney (HEK) cells. Our results indicate that BNNTs are cytotoxic for all cell types studied and, in most cases, are more cytotoxic than CNTs in their pristine (p-CNT) and functionalized (f-CNT) form. However, the level of toxicity and the prominent morphological alterations in the cell populations withstanding BNNT exposure are cell-type-dependent. For instance, BNNTs induced extensive multinucleated giant cell formation in macrophages and increased levels of eosinophilia in fibroblasts. Finally, our results point the toxicity of tubular nanomaterials to be strongly correlated with the cellular accumulation enhanced for straight nanotubes.

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Section: à5mentioning

confidence: 99%

In Vitro Investigation of the Cellular Toxicity of Boron Nitride Nanotubes

et al. 2011

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“…These studies greatly enhanced our understanding on the properties of BNNTs. They show that BNNTs could be used in many potential applications especially nano-biomedical application222324252627.…”

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confidence: 99%

Theoretic Study on Dispersion Mechanism of Boron Nitride Nanotubes by Polynucleotides

Liang

Zhang

et al. 2016

Sci Rep

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Due to the unique electrical and mechanical properties of boron nitride nanotubes (BNNT), BNNT has been a promising material for many potential applications, especially in biomedical field. Understanding the dispersion of BNNT in aqueous solution by biomolecules is essential for its use in biomedical applications. In this study, BNNT wrapped by polynucleotides in aqueous solution was investigated by molecular dynamics (MD) simulations. Our results demonstrated that the BNNT wrapped by polynucleotides could greatly hinder the aggregation of BNNTs and improve the dispersion of BNNTs in aqueous solution. Dispersion of BNNTs with the assistance of polynucleotides is greatly affected by the wrapping manner of polynucleotides on BNNT, which mainly depends on two factors: the type of polynucleotides and the radius of BNNT. The interaction between polynucleotides and BNNT(9, 9) is larger than that between polynucleotides and BNNT(5, 5), which leads to the fact that dispersion of BNNT(9, 9) is better than that of BNNT(5, 5) with the assistance of polynucleotides in aqueous solution. Our study revealed the molecular-level dispersion mechanism of BNNT with the assistance of polynucleotides in aqueous solution. It shades a light on the understanding of dispersion of single wall nanotubes by biomolecules.

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“…The cell compatibility of BNNTs was first studied by Ciofani et al [8]. Research results show that poly ethylene imine modified BNNTs does not produce great influence [9] on neuroblastoma survival, metabolism and cell regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Chlorophenol (CPs) pollutants is the formation of dioxin pops precursor, has strong teratogenic, carcinogenic and mutagenic. As a new material to explore the removal these pollutants, using density functional theory (8,0) to research the adsorption behavior and mechanism of action of single wall boron nitride nanotubes (BNNT) and Co doped (8,0) single-walled boron nitride nanotube (Co-BNNT) to 2-(2-CP), 2,4,6-three chlorophenols (TCP), chlorophenols pentachlorophenol (PCP) . The results showed that compared with BNNT, Co-BNNT near the Fermi level is a hybrid state, the band gap decreases.…”

Section: Introductionmentioning

confidence: 99%

Review On The Application Of Boron Nitride Nanotubes

Wang¹,

Chen²,

Li³

2016

Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics

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Abstract. Boron nitride nanotubes (BNNTs) is a kind of material which have similar structure with carbon nanotubes (CNTs), but have more excellent performance, through experiments and research, scientists have a more thorough understanding of the preparation methods and properties of BNNTs, at the same time, they also explored the application value of BNNTs. This article summarized and introduced the application of BNNTs from the composite additives, hydrogen storage materials, biomedical materials and environmental purification material, and prospected the future development of BNNTs..

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Boron Nitride Nanotubes: A Novel Vector for Targeted Magnetic Drug Delivery

Cited by 92 publications

References 26 publications

In Vitro Investigation of the Cellular Toxicity of Boron Nitride Nanotubes

In Vitro Investigation of the Cellular Toxicity of Boron Nitride Nanotubes

Theoretic Study on Dispersion Mechanism of Boron Nitride Nanotubes by Polynucleotides

Review On The Application Of Boron Nitride Nanotubes

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