Boronic acid functionalized graphene quantum dots as a fluorescent probe for selective and sensitive glucose determination in microdialysate

Qu, Zhi‐bei; Zhou, Xin; Gu, Li; Lan, Renmin; Sun, Dandan; Yu, Dajun; Shi, Guoyue

doi:10.1039/c3cc44393k

Cited by 186 publications

(93 citation statements)

References 20 publications

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“…[30,31] As shown in Figure 6, addition of glucose to HPAMAMs-B3 solution results in an immediate decrease in intrinsic fluorescence (ex 310 nm, em 378 nm), reaching a maximum decrement of about 86.68% after 3 min. In the case of HPAMAMs-B1 and HPAMAMs-B2, the maximum decrement is around 85.66 and 76.06%, respectively.…”

Section: Resultsmentioning

confidence: 93%

Facile one-pot synthesis of fluorescent hyperbranched polymers for optical detection of glucose

Jiang

Wang

et al. 2014

Designed Monomers and Polymers

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Fluorescent and glucose-sensitive hyperbranched poly(amidoamine)s (HPAMAMs-B) were synthesized via Michael addition of 1-(2-aminoethyl) piperazine, methyl acrylate, and 3-aminobenzeneboronic acid (APBA). These hyperbranched polymers emitted chartreuse photoluminescence and showed emission band at 378 nm under excitation wavelength. The intensity of emission band was enhanced with increasing the amount of APBA in HPAMAMs-B. The glucose sensitivity of HPAMAMs-B has been investigated at different glucose concentrations and pH conditions. These hyperbranched polymers showed potential for biomedical applications such as fluorescence imaging technology and glucose detecting sensors.

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Section: Resultsmentioning

confidence: 93%

Facile one-pot synthesis of fluorescent hyperbranched polymers for optical detection of glucose

Jiang

Wang

et al. 2014

Designed Monomers and Polymers

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“…35b). Then the nanohybrid offered a facile and low cost detection method of glucose with high sensitivity and selectivity [253]. There was a good linear FL response in a wide range from 0.1 to 10 mM.…”

Section: Glucose Detectionmentioning

confidence: 96%

“…35 a Proposed glucose-sensing mechanism based on BBV receptor and PL CDs [252]. b Schematic representation of the functionalization of CDs with APBA (upper) and proposed mechanism of surface quenching states (SQS) for glucose recognition [253] …”

Section: Glucose Detectionmentioning

confidence: 99%

Carbon Based Dots and Their Luminescent Properties and Analytical Applications

Dong

Jian-Hua

Chi

2016

Carbon Nanoparticles and Nanostructures

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Carbon based dots (CDs) composed of sp 2 carbon structures and surface functional groups are a new kind of carbon nanomaterials, exhibiting unique luminescent properties due to the quantum confinement and edge effects. This chapter introduces CDs in detail from their synthetic strategies, morphological and structural characteristics, luminescent properties and mechanisms, and sensing applications. The synthesis methods are summarized as "top-down" and "bottomup" approaches. Luminescent properties discussed include photoluminescence, upconversion luminescence, chemiluminescence, electrochemiluminescence. Sensing applications mainly refer to the chemical and biological sensors based on the luminescent properties of CDs. This chapter provides an overview of the research field and gives future perspectives for developing the exciting materials.

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“…[ 29,31 ] The specifi c bindings between PBA and diols are widely used to construct micelles, hydrogels, and biosensors. [32][33][34] In addition, PBA is capable of forming reversible covalent esters with the ribose ring of DNA or siRNA, thus cationic polymers modifi ed with PBA can bind with nucleic acid via the boronic ester linkage except ionic interactions. [ 35 ] PBA containing polymers are also used as gene vectors based on these promising properties.…”

mentioning

confidence: 99%

Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity

Liu

Shao

Wang

et al. 2016

Adv Healthcare Materials

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Cationic dendrimers are widely used as nonviral gene vectors, however, current gene materials based on dendrimers are either little effective or too toxic on the transfected cells. Here, a facile strategy is presented to prepare high efficient dendrimers with low transfection toxicity. Small dendrimers with 2 nm are clustered into nanoaggregates (≈100 nm) via phenylboronic acid modification and the self-assembled materials enable efficient DNA and siRNA delivery on several cell lines. The clustered nanostructures can disassemble into small dendrimers in acidic conditions thus exerting significantly less toxicity on the transfected cells. Further structure-function relationship studies reveal that both the phenyl group and boronic acid group play essential roles in the self-assembly and gene delivery processes. The transfection efficacy of phenylboronic acid-modified dendrimers can be down-regulated by blocking the boronic acid groups on dendrimers with diols or degrading the groups with hydrogen peroxide. This study provides a facile strategy in the development of efficient and biocompatible gene vectors based on low molecular weight polymers and clearly demonstrates the structure-function relationship of phenylboronic acid-modified polymers in gene delivery.

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Boronic acid functionalized graphene quantum dots as a fluorescent probe for selective and sensitive glucose determination in microdialysate

Abstract: 3-Aminobenzeneboronic acid functionalized graphene quantum dots (APBA-GQDs) were synthesized and used as a selective and sensitive sensing system for glucose. Combined with microdialysis, glucose was monitored successfully in vivo in the striatum of rat.

Cited by 186 publications

References 20 publications

Facile one-pot synthesis of fluorescent hyperbranched polymers for optical detection of glucose

Facile one-pot synthesis of fluorescent hyperbranched polymers for optical detection of glucose

Carbon Based Dots and Their Luminescent Properties and Analytical Applications

Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity

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