Boswellic Acids Show In Vitro Activity against Leishmania donovani

Greve, Hippolyt L.; Kaiser, Marcel; Mäser, Pascal; Schmidt, Thomas J.

doi:10.3390/molecules26123651

Cited by 8 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study has demonstrated, for the first time, fractions rich in secondary metabolites such as terpenes and their derivatives present in the leaves of M. alceifolia , which confer a possible in vitro action against the axenic amastigote and in silico action against some key proteases in the biosynthetic pathways of L. mexicana . However, studies have demonstrated that triterpene extracts and fractions obtained from Boswellia and Commiphora spp., particularly methyl Commate A (boswellic acids), exhibit activity against axenic amastigotes L. donovani [ 45 , 46 , 47 ]. β-Amyrin from Leuconotis eugenifolius inhibited L. donovani and extracts of species of the genus Eugenia ( E. uniflora and E. umbeliflora ) against L. amazonensis [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

et al. 2023

View full text Add to dashboard Cite

Malachra alceifolia Jacq. (family Malvaceae), known as “malva,” is a medicinal plant used as a traditional therapy in many regions of America, Africa and Asia. Traditionally, this plant is used in the form of extracts, powder and paste by populations for treating fever, stomachache, inflammation, and parasites. However, the ethnopharmacological validation of M. alceifolia has been scarcely researched. This study showed that the chloroform fraction (MA-IC) and subfraction (MA-24F) of the leaves of M. alceifolia exhibited a potential antileishmanial activity against axenic amastigotes of Leishmania mexicana pifanoi (MHOM/VE/60/Ltrod) and had high and moderate cytotoxic effects on the viability and morphology of macrophages RAW 264.7. This study reports, for the first time, possible terpenoid metabolites and derivatives present in M. alceifolia with activity against some biosynthetic pathways in L. mexicana amastigotes. The compounds from the subfractions MA-24F were highly active and were analyzed by gas chromatography-mass spectrometry (GC-MS) and by a molecular docking study in L. mexicana target protein. This study demonstrates the potential modes of interaction and the theoretical affinity energy of the metabolites episwertenol, α-amyrin and methyl commate A, which are present in the active fraction MA-24F, at allosteric sites of the pyruvate kinase, glyceraldehyde-3-phosphate dehydrogenase, triose phosphate isomerase, aldolase, phosphoglucose isomerase, transketolase, arginase and cysteine peptidases A, target proteins in some vital biosynthetic pathways were responsible for the survival of L. mexicana. Some phytoconstituents of M. alceifolia can be used for the search for potential new drugs and molecular targets for treating leishmaniases and infectious diseases. Furthermore, contributions to research and the validation and conservation of traditional knowledge of medicinal plants are needed globally.

show abstract

Section: Resultsmentioning

confidence: 99%

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

et al. 2023

View full text Add to dashboard Cite

show abstract

“…To determine the anti-leishmanial (L. major) activity of any compound inhibitory (IC50), cytotoxic (CC50), and effective concentrations (EC50) are measured, similarly the anti-leishmanial activity of U. dioica extract from leaves was determined to suppressing promastigotes and amastigotes growth and the best concentrations were 3500 and 6000 μg/ml [25]. L. donovani axenic amastigotes IC50: 0.88 µM [26] Crude extracts and fractions…”

Section: Anti-leishmanial Compoundsmentioning

confidence: 99%

“…Quercetin-3,7-dimethylether L. donovani IC50: 4.5 ± 0. In other research studies [26] 3-O-acetyl-11-keto-β-boswellic acid (AKBA) is extracted from the Boswellia serrata resin which showed antileishmanial activity. The activity was seen against L. donovani.…”

Section: Stems Of Cuscuta Hyalinamentioning

confidence: 99%

“…Boswellia serrata Roxb is a deciduous tree with a greyish papery bark that produces a fragrant yellowish oleo-gum-resin known as Indian frankincense or Olibanum, which has anti-inflammatory properties[44]. 3-O-acetyl-11-keto-boswellic acid (AKBA) had an IC50 of 0.88 μM against axenic amastigotes but was ineffective against intracellular amastigotes in murine macrophages [26]. In 2020 Mahmoud et.…”

Section: Stems Of Cuscuta Hyalinamentioning

confidence: 99%

See 1 more Smart Citation

Exploration of Antileishmanial Compounds Derived from Natural Sources <strong> </strong>

Peer¹,

Chang²,

Raj³

et al. 2022

Preprint

View full text Add to dashboard Cite

Leishmaniasis is considered one of the different neglected tropical diseases by the World Health Organization. Over the past few decades to tackle leishmaniasis, effective and novel drugs have progressed. But few are expensive some other medication shows poor effects and few drugs with long treatment lead to cause resistance. But it is very important to start a better medication against leishmania so researchers came to the front of the utilization of natural products which are considered a better option. Finding active compounds in medicinal plants is another alternative to currently accessible medications. Materials and methods: This study examined and reported the far more potential natural products used to treat disease caused by Leishmania spp. Leishmaniasis, plant metabolites, in vivo, in vitro, and treatment against leishmaniasis have been used as search terms in the Google Scholar, PubMed, and Science Direct databases, and only papers published between 2015 and 2021 have been chosen for further analysis. Results: The use of novel natural compounds with leishmanicidal action as well as the leishmanicidal activity of natural compounds against promastigote, axenic, and intracellular amastigote forms were included in roughly 20 research papers that were reviewed.Conclusion: Due to their capacity to selectively target parasites without harming host cell viability, herbal plants are a possible source of new anti-leishmanial medication. Future leishmaniasis treatments will draw on the isolated compounds as a source, completing those already offered in clinics.

show abstract

“…Leishmaniasis causes 20,000–30,000 deaths worldwide every year. It is transmitted to humans through the bite of infected female sandflies (Greve et al., 2021). The disease has three forms: cutaneous leishmaniasis ( Leishmania major , Leishmania tropica , Leishmania mexicana , and Leishmania amazonensis ), which is the most common and causes skin lesions and scarring; mucocutaneous leishmaniasis ( Leishmania braziliensis ), which affects the nasal and oral mucosa and can extend to the oropharynx and larynx; and visceral leishmaniasis ( Leishmania donovani and Leishmania infantum / Leishmania chagasi ), the most severe form, also known as kala‐azar.…”

Section: Introductionmentioning

confidence: 99%

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Soto‐Sánchez

2024

Chem Biol Drug Des

View full text Add to dashboard Cite

Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Terpenes are secondary metabolites with pharmacological potential. This aim of this mini‐review is to explore the most promising natural terpenes with anti‐leishmanicidal, anti‐schistosomicidal, and anti‐echinococcal activity, their mechanisms of action, and their efficacy as combination therapy. The study identified a tetracyclic diterpenoid, a sesquiterpene lactone, and a triterpene with the highest biological activity against leishmaniasis. Additionally, a triterpenoid and a tetraterpene showed potent activity against schistosomiasis and echinococcosis, respectively. Compounds have antiparasitic effects by inducing cell death, inhibiting cell stress‐related proteins, degrading extracellular matrix, and modulating immune and inflammatory responses. The employment of combination therapy and terpene nanotransporters appears to enhance the antiparasitic activity of these compounds. Although identifying specific molecular targets is necessary, the use of terpenes in combination therapy presents a safe and highly promising approach for the rational development of more potent and selective antiparasitic drugs.

show abstract

Boswellic Acids Show In Vitro Activity against Leishmania donovani

Cited by 8 publications

References 16 publications

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

Exploration of Antileishmanial Compounds Derived from Natural Sources <strong> </strong>

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Contact Info

Product

Resources

About